ASSESSMENT OF PHYTOCHEMICAL CONSTITUENTS, IN VITRO ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF ULVA EXTRACTS FROM VISHAKHAPATNAM COAST


Princely S, Dhanaraju Md

Abstract


 

 Objective: Antimicrobial drug resistance is the foremost problem faced worldwide with the current antibiotic therapy in treating infectious diseases. Marine algae were considered as a potential source of biologically active compounds with antibacterial, antifungal, antiviral, and anticancer activities.

Materials and Methods: In the present investigation, the purified fractions of marine algal crude extracts of different solvents such as aqueous, ethyl acetate (EtAc), and ethanol for antioxidant (1,1-diphenyl-2-picrylhydrazyl radical scavenging assay) and antimicrobial activities (agar well diffusion assay) were evaluated.

Results: The extracts of EtAc, ethanol, and water showed minimum inhibitory concentration values of 3.125, 6.25, and 12.25 μg/ml, respectively, for tested bacterial pathogens. The active fractions showed very little activity against Klebsiella pneumonia and Salmonella Typhi, and no activity was observed against Pseudomonas aeruginosa. The results of our screening showed that the EtAc marine algal fractions were active against some Gram-positive, Gram-negative bacteria and Candida albicans. The phytochemical analysis of aqueous, ethanolic, and EtAc extracts of marine algae showed the presence of the various phytochemical constituents such as carbohydrates, phenols, and amino acids. The ethanolic extracts showed the highest antioxidant activity as compared to aqueous and EtAc extracts.

Conclusion: This work can be extended further to isolate, characterize, and discover more bioactive metabolites from marine algae, which can be exploited for the production of lead molecules in pharmaceuticals for the treatment of chronic diseases.


Keywords


Marine algae, Phytochemicals, Antimicrobial, Antioxidant, 1,1-diphenyl-2-picrylhydrazyl

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About this article

Title

ASSESSMENT OF PHYTOCHEMICAL CONSTITUENTS, IN VITRO ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF ULVA EXTRACTS FROM VISHAKHAPATNAM COAST

Keywords

Marine algae, Phytochemicals, Antimicrobial, Antioxidant, 1,1-diphenyl-2-picrylhydrazyl

DOI

10.22159/ajpcr.2017.v10i8.18582

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 87-95

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

76 Views | 123 Downloads

Authors & Affiliations

Princely S
Department of Pharmaceutical Biotechnology, Research Laboratory, GIET School of Pharmacy, Rajahmundry - 533 296, Andhra Pradesh, India.
India

Dhanaraju Md
Department of Pharmaceutical Biotechnology, Research Laboratory, GIET School of Pharmacy, Rajahmundry - 533 296, Andhra Pradesh, India.
India


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