FABRICATION AND EFFECT OF PROCESS VARIABLES OF SITAGLIPTIN MICROSPHERES


Revathi S, Dhanaraju Md

Abstract


 Objective: The study is to formulate and assess the effects of different variables on the release profile of sitagliptin microspheres.

Methods: The microspheres were prepared by emulsion-solvent diffusion method and ionotropic gelation method using ethyl cellulose and sodium alginate as the polymers, respectively. The formulations are optimized by applying 23 factorial design based on the drug-polymer ratio, stirring speed, and method of preparation.

Results: The drug-polymer interaction was checked by the Fourier-transform infrared spectroscopy and differential scanning calorimetry the results of which indicated no incompatibility. The formulated sitagliptin microspheres were evaluated for shape, morphology, particle size, the degree of swelling, encapsulation efficiency, in vitro drug release studies for 12 h, and kinetics of drug release.

Conclusion: The results showed that the drug-polymer ratio and stirring speed affected the particle size and drug release. The release of the drug was found to be sustained, and diffusion path is following cube root law of Hixson-Crowell kinetics. The batch F3 was found to be desirable and was further characterized by scanning electron microscope for morphology.


Keywords


Sitagliptin, Factorial, Ethyl cellulose, Solvent diffusion.

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About this article

Title

FABRICATION AND EFFECT OF PROCESS VARIABLES OF SITAGLIPTIN MICROSPHERES

Keywords

Sitagliptin, Factorial, Ethyl cellulose, Solvent diffusion.

DOI

10.22159/ajpcr.2018.v11i4.24068

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 291-297

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

25 Views | 66 Downloads

Authors & Affiliations

Revathi S
Department of Pharmaceutics, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
India

Dhanaraju Md
Department of Pharmaceutics, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
India


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