TRI-E® PREVENTS COGNITIVE IMPAIRMENT AND DEOXYRIBONUCLEIC ACID DAMAGE IN DIABETES MELLITUS

Authors

  • Holifa Saheera Asmara Lecturer, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]
  • Zubaidi Abdul Latif Professor of Neuro-surgery Unit and Vice Chancellor, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]
  • Ahmed Ghazi Faisal 3. Lecturer, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]
  • Mainul Haque Professor of the Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia. Email: [email protected]

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.20435

Keywords:

Diabetes, Deoxyribonucleic acid damage, Cognitive decline, Comet assay, Tocotrienol

Abstract

 

 Objective: The aim of the current study is to compare the difference of Tri-E® and ATF potentials in reducing diabetic adverse event due to hyperglycemia that might cause the DNA damage and cognitive impairment indirectly.

Methods: Diabetic model sample from Sprague Dawley was developed by combination of twice low-dose streptozotocin injection and high fat diet. The diabetic rat model was treated with Tri-E® and ATF in different groups, control group were provided. The DNA was collected from the whole blood and DNA damage was measured using the comet assay method. While cognitive status was measured using Morris water-maze method.

Result: Reduction of the DNA damage and improvement of cognitive function were observed in both ATF and Tri-E® supplementations that elevated in diabetic. However, the DNA damage reduction by Tri-E® was one-fold higher compared to ATF supplementation.

Conclusion: This study provided data that Tri-E® has superior potential than ATF as a preventative agent to DNA damage and cognitive impairment in diabetes indirectly.

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Author Biographies

Holifa Saheera Asmara, Lecturer, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]

Biochemistry

Zubaidi Abdul Latif, Professor of Neuro-surgery Unit and Vice Chancellor, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]

Surgery

Ahmed Ghazi Faisal, 3. Lecturer, Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia. Email: [email protected]

Biochemistry

Mainul Haque, Professor of the Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia. Email: [email protected]

Pharmacology

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Published

01-09-2017

How to Cite

Asmara, H. S., Z. A. Latif, A. G. Faisal, and M. Haque. “TRI-E® PREVENTS COGNITIVE IMPAIRMENT AND DEOXYRIBONUCLEIC ACID DAMAGE IN DIABETES MELLITUS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 9, Sept. 2017, pp. 373-6, doi:10.22159/ajpcr.2017.v10i9.20435.

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