TRI-EÂ® PREVENTS COGNITIVE IMPAIRMENT AND DEOXYRIBONUCLEIC ACID DAMAGE IN DIABETES MELLITUS
Keywords:Diabetes, Deoxyribonucleic acid damage, Cognitive decline, Comet assay, Tocotrienol
Â Objective: The aim of the current study is to compare the difference of Tri-EÂ® and ATF potentials in reducing diabetic adverse event due to hyperglycemia that might cause the DNA damage and cognitive impairment indirectly.
Methods: Diabetic model sample from Sprague Dawley was developed by combination of twice low-dose streptozotocin injection and high fat diet. The diabetic rat model was treated with Tri-EÂ® and ATF in different groups, control group were provided. The DNA was collected from the whole blood and DNA damage was measured using the comet assay method. While cognitive status was measured using Morris water-maze method.
Result: Reduction of the DNA damage and improvement of cognitive function were observed in both ATF and Tri-EÂ® supplementations that elevated in diabetic. However, the DNA damage reduction by Tri-EÂ® was one-fold higher compared to ATF supplementation.
Conclusion: This study provided data that Tri-EÂ® has superior potential than ATF as a preventative agent to DNA damage and cognitive impairment in diabetes indirectly.
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