SYNERGISTIC ANTICANDIDAL ACTIVITY OF TWO TERMINALIA SPECIES WITH POLYENE AND AZOLE GROUP OF ANTIBIOTICS AGAINST MULTIDRUG-RESISTANT CLINICAL ISOLATES OF CANDIDA


Tejas Rathod, Hemali Padalia, Sumitra Chanda

Abstract


Objectives: The aim of the present study was to evaluate synergistic anticandidal activity of two Terminalia species with polyene and azole group of antibiotics against multidrug-resistant clinical isolates of Candida.

Methods: The synergistic effect of ethanol extract of leaf of Terminalia cattapa. and Terminalia chebula with six standard antibiotics, namely, amphotericin B, nystatin, fluconazole (FLC), ketoconazole (KT), clotrimazole (CC), and itraconazole (IT) was evaluated against the clinical isolates by disk diffusion assay.

Results: The synergistic activity of the antibiotics with ethanol extract of T. chebula was better than with that of T. cattapa. T. chebula ethanol extract increased the anticandidal effect of azole antibiotics FLC and KT, while it had a less synergistic effect on CC and IT.

Conclusion: Therefore, FLC/KT plus ethanol extract of T. chebula can be an interesting and alternative source of anticandidal agent against Candida species.


Keywords


Terminalia chebula, Terminalia catappa, Antibiotics, Fluconazole, Synergistic activity, Anticandidal agent.

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About this article

Title

SYNERGISTIC ANTICANDIDAL ACTIVITY OF TWO TERMINALIA SPECIES WITH POLYENE AND AZOLE GROUP OF ANTIBIOTICS AGAINST MULTIDRUG-RESISTANT CLINICAL ISOLATES OF CANDIDA

Keywords

Terminalia chebula, Terminalia catappa, Antibiotics, Fluconazole, Synergistic activity, Anticandidal agent.

DOI

10.22159/ajpcr.2018.v11i1.21664

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 138-142

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Tejas Rathod
Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India
India

Hemali Padalia
Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India
India

Sumitra Chanda
Department of Biosciences (UGC-CAS), Phytochemical, Pharmacological and Microbiological Laboratory, Saurashtra University, Rajkot - 360 005, Gujarat, India
India


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