DIFFERENCES IN DENTAL CALCULUS INDICES AND SALIVARY CALCIUM AND PHOSPHATE LEVELS IN CHILDREN WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS AND PERITONEAL DIALYSIS THERAPY

  • Thea Kirana Department Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.
  • Heriandi Sutadi Department Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.
  • Sarworini B Budiardjo Department Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.

Abstract

 Objective: The objective of this study is to analyze the differences in dental calculus indices and calcium and phosphate levels in children with chronic kidney disease undergoing hemodialysis (HD) and peritoneal dialysis (PD) therapy.

Methods: In this cross-sectional study, 15 children undergoing HD therapy and 15 undergoing PD therapy were subjected to intraoral examination for dental calculus indices. Whole unstimulated saliva samples of all subjects were collected and subjected to calcium and phosphate analysis. Statistical analyses were conducted using the Mann–Whitney and independent t-tests.

Results: The dental calculus indices were significantly lower and salivary calcium level was significantly higher in the PD group than those in the HD group (p<0.05). The salivary phosphate level was lower in the PD group (p≥0.05) but without significance.

Conclusion: The PD group had lower dental calculus indices and higher salivary calcium level. The higher salivary phosphate levels in the HD group may have contribute to the higher dental calculus indices, probably because phosphate plays an important role in dental calculus formation.

Keywords: Chronic kidney disease, Dental calculus indices, Hemodialysis, Peritoneal dialysis, Salivary calcium, Salivary phosphate.

References

1. Rejane M, Canabarro T, Loren S, Salazar A, Ferreira-pereira A, Maria R, et al. Role of saliva in the caries experience and calculus formation of young patients undergoing hemodialysis. Clin Oral Invest 2015;19:1973-80.
2. Yahwa NB, Ali B. The dental and oral status of children with chronic renal failure. J Indian Soc Pedod Prev Dent 2007;25:106-8.
3. Seraj B, Ahmadi R, Ramezani N, Mashayekhi A, Ahmadi M. Oro-dental health status and salivary characteristics in children with chronic renal failure. J Dent (Tehran) 2011;8:146-51.
4. Bayraktar G, Kurtulus I, Kazancioglu R, Bayramgurler I, Cintan S, Bural C, et al. Evaluation of periodontal parameters in patients undergoing peritoneal dialysis or hemodialysis. Oral Dis 2008;14:185-9.
5. Riaño I, Malaga S, Callis L, Loris C, Martin-Govantes J, Navarro M, et al. Towards guidelines for dialysis in children with end-stage renal disease. Pediatr Nephrol 2000;15:157-62.
6. Müller D, Goldstein SL. Hemodialysis in children with end-stage renal disease. Nat Rev Nephrol 2011;7:650-8.
7. Aboelyazeed H, El-haggar S, Okasha K. Comparative study between the effect of histamine receptor antagonists of Type II (Famotidine) and proton pump inhibitors (Omeprazole) on the efficacy of calcium carbonate as phosphate binder in.haemodialysis patient. Int J Pharm Pharm Sci 2017;9:10-4.
8. Davidovich E, Davidovits M, Peretz B, Shapira J, Aframian DJ. The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease. Nephrol Dial Transplant 2009;24:2439-45.
9. Yavuz A, Ersoy FF, Passadakis PS, Tam P, Evaggelos DM, Katopodis KP, et al. Phosphorus control in peritoneal dialysis patients. Kidney Int Suppl 2008;73:S152-8.
10. Rodrigues VP, Franco MM, Marques CP, de Carvalho RC, Leite SA, Pereira AL, et al. Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients. Arch Oral Biol 2016;62:58-63.
11. Davidovich E, Frishberg Y, Aframian DJ, Peretz B. Calculus in a toddler with end-stage renal disease due to prune-belly syndrome. Oral Dis 2006;12:63-6.
12. Sihombing J, Hakim L, Andayani TM, Irijanto F. Quality of life of chronic kidney disease patients with routine hemodialysis in general hospitals in Sleman Yogyakarta. Int J Pharm Pharm Sci 2017;9:213-6.
13. Bayraktar G, Kurtulus I, Kazancioglu R, Bayramgurler I, Cintan S, Bural C, et al. Effect of educational level on oral health in peritoneal and hemodialysis patients. Int J Dent 2009;2009:159767.
14. Melamed ML, Eustace JA, Plantinga L, Jaar BG, Fink NE, Coresh J, et al. Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: A longitudinal study. Kidney Int 2006;70:351-7.
15. Wang AY. Calcium balance and negative impact of calcium load in peritoneal dialysis patients. Perit Dial Int 2014;34:345-52.
16. Honarmand M, Farhad-Mollashahi L, Nakhaee A, Sargolzaie F. Oral manifestation and salivary changes in renal patients undergoing hemodialysis. J Clin Exp Dent 2017;9:e207-e210.
17. Martins C, Siqueira WL, Primo LG. Dental calculus formation in children and adolescents undergoing hemodialysis. Pediatr Nephrol 2012;27:1961-6.
18. Mahdavi-Mazdeh M, Zamyadi M, Norouzi S, Heidary Rouchi A. Management of calcium and phosphorus metabolism in hemodialysis patients in tehran province, Iran. Iran J Kidney Dis 2007;1:25-8.
19. Rroji M, Seferi S, Cafka M, Petrela E, Likaj E, Barbullushi M, et al. Is residual renal function and better phosphate control in peritoneal dialysis an answer for the lower prevalence of valve calcification compared to hemodialysis patients? Int Urol Nephrol 2014;46:175-82.
20. Tawfig A, Alsaadoon A, Alasmari B, Aleid M, Balbhaith M, Aljabr S. Dental calculus formation among recurrent renal calculi formers. Int J Dent Oral Heal 2017;3:7-12.
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How to Cite
Kirana, T., H. Sutadi, and S. B Budiardjo. “DIFFERENCES IN DENTAL CALCULUS INDICES AND SALIVARY CALCIUM AND PHOSPHATE LEVELS IN CHILDREN WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS AND PERITONEAL DIALYSIS THERAPY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 3, Mar. 2018, pp. 339-41, doi:10.22159/ajpcr.2018.v11i3.23275.
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