• Suman Sharma Department of Zoology and Environmental Sciences, Punjabi University, Patiala – 147 002, Punjab, India.
  • Anjali Singh Gill Department of Zoology and Environmental Sciences, Punjabi University, Patiala – 147 002, Punjab, India.



Arsenic (As), Chromosomes, Zingiber officinale, Genotoxicity


Objective: The present study investigated the antigenotoxic effect of Zingiber officinale (Ginger) on arsenic-induced genotoxic effects in chromosome structure of Swiss albino mice.

Methods: Albino mice were divided into four groups: Group I was kept as control, Group II was administrated an oral dose of arsenic trioxide 5 mg/kg bw for 15 days, Group III was given an oral dose of arsenic trioxide 5 mg/kg bw followed by 20 mg/kg bw of ginger orally, and Group IV was administered with 20 mg/kg bw of ginger orally for 15 days and kept as positive control. The autopsies were done from all the groups on 15-day post-treatment, and bone marrow was removed for chromosomal study and for calculating the frequency of micronuclei (MN).

Results: It is concluded from this study that long-term arsenic exposure causes chromosomal anomalies, for example, breaks, gaps, rings, stretching, and stickiness which leads to the fragmentation of chromosomes and increases the frequency of MN.

Conclusion: The administration of ginger showed modulatory effects against arsenic-induced genotoxicity.


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How to Cite

Sharma, S., and A. S. Gill. “RESTORATIVE EFFECTS OF ZINGIBER OFFICINALE ON ARSENIC-INDUCED GENOTOXIC EFFECTS IN CHROMOSOMAL STRUCTURE OF MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 7, July 2018, pp. 471-5, doi:10.22159/ajpcr.2018.v11i7.26505.



Original Article(s)