ELEMENTAL ANALYSIS OF AYURVEDIC DRUGS (BHASMAS) BY ATOMIC ABSORPTION SPECTROMETER
Objective: Ayurvedic drugs/bhasmas are very potent and promising drugs for the treatment of various ailments. Bhasmas are the multielement samples, and the present work deals the analysis of the concentration of metallic elements in three ayurvedic bhasmas of four different brands, to compare and know the quality of commercial bhasma in market.
Methods: Commercially available abhraka bhasma (AB), mandoor bhasma (MB), and godanti bhasma (GB) in market from four different manufacturing companies were procured, and bhasma sample solution was prepared to analyze the elemental concentrations in bhasma; the solution is subjected to flame atomic absorption spectrometer (FAAS) technique and determined elemental concentration in bhasmas of four different commercial brands.
Results: FAAS analysis explores the presence of Mg, Al, K, Ca, Cr, Mn, Fe, Cu, Zn, Mo, and Cd elements’ concentration in three bhasmas/drugs by four manufacturers. AB is rich in Al and Fe following the other elements in low concentrations, MB is rich in Fe, Ca, Mn, Cu, K, and Al and other elements are present in less quantity, and GB is rich in Ca and all other elements were very less in quantity.
Conclusion: FAAS analysis showed that there is a difference in quantity/concentration of elements present in bhasma, aluminum (Al) is found high in Patanjali brand bhasmas compared to other three brands, and the toxic metal cadmium (Cd) is found in Dhootapapeshwar mandoor bhasma (DMB) (0.0458 mg/l), except DMB, all bhasmas found free from toxic metals, which reveal that there is a variation in quality of bhasmas from different manufacturers, and the elements present in bhasmas are found to be in permissible range for human intakes. As the mineral elements are essential in human diet, if the amount of any elements becomes too high in body, then it can affect the functioning of other important minerals in body causing the severe health problems, so it is must, to balance all nutrients in human diet, either through food or medicines. Hence, the present analysis work focuses on the variation of concentrations of elements present in bhasma of different manufacturers, which will help in practitioners to compare and refer good quality bhasmas or drugs in terms of their ingredients/elements, which plays a major role in functioning of human body normally. Further work is necessary to carry out on bhasmas and ayurvedic formulations in order to get good of diet supplementation.
2. Ashwini A, Kerur BR. Estimation of heavy and trace elements in ayurvedic drug (loha bhasma) alternative medicine for anemia by AAS and ICP-OES. Int J Res Aturvedia Pharm 2017;8:81-5.
3. Tripathi YB. A multidisciplinary approach to standardize bhasmas (ayurvedic metallic preparations) Curr Sci 2006;90:897-8.
4. Arya RK. Characterization of bioactive nanoparticles-bhasma an Indian ayurveda drug. Indian J Pharm Educ Res 2014;48:61-8.
5. Mulchand S, Seema M. Formulation of polyherbomineral matrices for treatment of osteoporosis. Asian J Pharm Clin Res 2018;11:217-23.
6. Chitnis KS, Stanley A. Chemical evaluation of tamra bhasma. Int J Pharm Bio Sci 2011;2:160-8.
7. Gupta RK, Lakshmi V, Jha CB. X-ray diffraction of different samples of swarna makshika bhasma. Ayu 2015;36:225-9.
8. Mishra A, Mishra AK, Tiwari OP, Jha S. In-house preparation and characterization of an ayurveda bhasma: Praval bhasma. J Integr Med 2014;12:52-8.
9. Kumar A, Nair AG, Reddy AV, Garg AN. Availability of essential elements in bhasmas: Analysis of ayurvedic metallic preparations by INAA. J Radioanal Nucl Chem 2006;270:173-80.
10. Monali BV, Vishal VP, Sarita SP. Formulation, standardization and comparative evaluation of ancient nanomedicine varatika bhasma. Int J Pharm Drug Anal 2015;3:126-33.
11. Gawate RP, Kilor VA, Sapkal NP. Physicochemical characterization and hepatoprotective activity of mandur bhasma. Int J Pharm Pharm Sci 2016;8:327-32.
12. Santoshi V, Shakila BA, Kurian GA. Synthesis, characterization and biological evaluation of iron oxide nanoparticles prepared by Desmodium gangeticum root aqueous extract. Int J Pharm Pharm Sci 2014;7 Suppl 1:75-80.
13. Krupanidhi S, Sreekumar A, Sanjeevi CB. Copper and biological health. Indian J Med Res 2008;128:448-61.
14. Delfgauw: Recommended Daily Intake of Vitamins and Minerals. Available from: https://www.lenntech.com/recommended-daily-intake.htm.
15. Schafer U, Seifert M. Oral intake of aluminum from foodstuffs, food additives, food packaging, cookware and pharmaceutical preparations with respect to dietary regulations. Trace Elem Electrolytes 2006;23:150-61.
16. WHO. Aluminium in Drinking Water; 2010. Available from: https://www.who.int/water_sanitation_health/waterquality/guidelines/chemicals/aluminium.pdf?ua=1.
17. WHO. Guideline: Potassium Intake for Adults and Children; 2012. Available from: https://www.who.int/nutrition/publications/guidelines/potassium_intake_printversion.pdf; https://www.who.int/elena/titles/guidance_summaries/potassium_intake/en/.
18. WHO. Calcium and Magnesium in Drinking-Water Public Health Significance; 2009. Available from: https://www.who.int/water_sanitation_health/publications/publication_9789241563550/en/.
19. WHO. Exposure to Cadmium: A Major Public Health Concern; 2010. Available from: https://www.who.int/ipcs/assessment/public_health/cadmium/en.
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