HELICHRYSUM LONGIFOLIUM AND HELICHRYSUM PEDUNCULATUM: A COMPARATIVE ANALYSIS OF THEIR MEDICINAL USES, CHEMISTRY AND BIOLOGICAL ACTIVITIES

ETHNOPHARMACOLOGY OF HELICHRYSUM LONGIFOLIUM AND H. PEDUNCULATUM

  • ALFRED MAROYI Department of Botany, Medicinal Plants and Economic Development Research Centre, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

Abstract

Helichrysum longifolium and Helichrysum pedunculatum have a long history of medicinal use, particularly managing wounds acquired during male circumcision rites in South Africa. There is a need to evaluate the existence of any correlation between the ethnomedicinal applications, the phytochemistry and pharmacological properties of the species. Therefore, in this review, analyses of the botanical, medicinal, and chemical and biological activities of H. longifolium and H. pedunculatum are presented as well as exploring the potential of the two species as important sources of health and pharmaceutical products. Information on the botany, medicinal uses, and phytochemistry and biological activities of H. longifolium and H. pedunculatum was assembled from several internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information was sourced from journal articles, scientific reports, theses, books, and book chapters obtained from the University library. This study showed that alkaloids, flavonoids, linoleic acid, oleic acid, phenol, proanthocyanidin, saponins, and tannins have been identified from the leaves of H. longifolium and H. pedunculatum. The pharmacological research showed that H. longifolium and H. pedunculatum extracts and compounds isolated from the species have antibacterial, antifungal, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, and cytotoxicity activities. For local communities to use H. longifolium and H. pedunculatum extracts with confidence as herbal medicines, there is a need for extensive phytochemical and pharmacological studies. Further research is required to establish the safety profiles of different H. longifolium and H. pedunculatum preparations.

Keywords: Ethnopharmacology,, Helichrysum longifolium,, Helichrysum pedunculatum,, Herbal medicine,, South Africa.

References

1. Liao F. Discovery of artemisinin (qinghaosu). Molecules 2009;14:5362-6.
2. Miller LH, Su X. Artemisinin: Discovery from the Chinese herbal garden. Cell 2011;146:855-8.
3. Udaykumar P. Discovery of artemisinin: The Chinese wonder drug. Muller J Med Sci Res 2014;5:191-2.
4. Weathers PJ, Towler M, Hassanali A, Lutgen P, Engeu PO. Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries? World J Pharmacol 2014;3:39-55.
5. Chang Z. The discovery of qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story. Sci China Life Sci 2016;59:81-8.
6. Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM. Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin. Proc Natl Acad Sci U S A 2015;112:821-6.
7. Pulice G, Pelaz S, Matías-Hernández L. Molecular farming in Artemisia annua, a promising approach to improve anti-malarial drug production. Front Plant Sci 2016;7:329.
8. Liu CX. Discovery and development of artemisinin and related compounds. Chin Herb Med 2017;9:101-14.
9. Abdolkarim C, Atri M, Yousefi S, Jalali F. Polyploidy variation in some species of the genus Artemisia L. (Asteraceae) in Iran. Caryologia 2010;63:168-75.
10. Gao T, Yao H, Song J, Zhu Y, Liu C, Chen S, et al. Evaluating the feasibility of using candidate DNA barcodes in discriminating species of the large Asteraceae family. BMC Evol Biol 2010;10:324.
11. Chehregani-Rad A, Mohsenzadeh F, Moazen F. Variation of chromosome numbers in Tanacetum parthenium Schultz Bip. (Asteraceae) in Iran. Chromosome Bot 2012;7:97-100.
12. Garcia S, Hidalgo O, Jakovljevi? I, Siljak-Yakovlev S, Vigo J, Garnatje T, et al. New data on genome size in 128 Asteraceae species and subspecies, with first assessments for 40 genera, 3 tribes and 2 subfamilies. Plant Biosyst 2013;147:1219-27.
13. Jana BK, Mukherjee SK. Exomorphic and histological characters of fruits in some taxa of the tribe Lactuceae-(Asteraceae). J Econ Taxon Bot 2013;37:372-8.
14. Barreda VD, Palazzesi L, Tellería MC, Olivero EB, Raine JI, Forest F. Early evolution of the angiosperm clade Asteraceae in the cretaceous of Antarctica. Proc Natl Acad Sci U S A 2015;112:10989-94.
15. Van Puyvelde L, De Kimpe N, Costa J, Munyjabo V, Nyirankuliza S, Hakizamungu E, et al. Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysetin. J Nat Prod 1989;52:629-33.
16. Heinrich M, Robles M, West JE, Ortiz de Montellano BR, Rodriguez E. Ethnopharmacology of Mexican Asteraceae (Compositae). Annu Rev Pharmacol Toxicol 1998;38:539-65.
17. Lourens AC, Viljoen AM, van Heerden FR. South African Helichrysum species: A review of the traditional uses, biological activity and phytochemistry. J Ethnopharmacol 2008;119:630-52.
18. Gouveia SC, Castilho PC. Validation of a HPLC-DAD–ESI/MSn method for caffeoylquinic acids separation, quantification and identification in medicinal Helichrysum species from Macaronesia. Food Res Int 2012;45:362-8.
19. Koc S, Isgor BS, Isgor YG, Moghaddam NS, Yildirim O. The potential medicinal value of plants from Asteraceae family with antioxidant defense enzymes as biological targets. Pharm Biol 2015;53:746-51.
20. Meyer JJ, Afolayan AJ, Taylor MB, Engelbrecht L. Inhibition of herpes simplex virus Type 1 by aqueous extracts from shoots of Helichrysum aureonitens (Asteraceae). J Ethnopharmacol 1996;52:41-3.
21. Meyer JJ, Afolayan AJ, Taylor MB, Erasmus D. Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J Ethnopharmacol 1997;56:165-9.
22. Afolayan AJ, Meyer JJ. The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol 1997;57:177-81.
23. Drewes SE, Mudau KE, van Vuuren SF, Viljoen AM. Antimicrobial monomeric and dimeric diterpenes from the leaves of Helichrysum tenax var tenax. Phytochemistry 2006;67:716-22.
24. van Vuuren SF, Viljoen AM, van Zyl RL, van Heerden FR, Hüsnü K, Ba?er C. The antimicrobial and toxicity profiles of helihumulone, leaf essential oil and extracts of Helichrysum cymosum (L.) D. Don subsp. cymosum. S Afr J Bot 2006;72:287-90.
25. Drewes SE, van Vuuren SF. Antimicrobial acylphloroglucinols and dibenzyloxy flavonoids from flowers of Helichrysum gymnocomum. Phytochemistry 2008;69:1745-9.
26. Kenny O, Smyth TJ, Walsh D, Kelleher CT, Hewage CM, Brunton NP, et al. Investigating the potential of under-utilised plants from the Asteraceae family as a source of natural antimicrobial and antioxidant extracts. Food Chem 2014;161:79-86.
27. Antunes Viegas D, Palmeira-de-Oliveira A, Salgueiro L, Martinez-de-Oliveira J, Palmeira-de-Oliveira R. Helichrysum italicum: From traditional use to scientific data. J Ethnopharmacol 2014;151:54-65.
28. Bessada SM, Barreira JC, Oliveira MB. Asteraceae species with most prominent bioactivity and their potential applications: A review. Ind Crops Prod 2015;76:604-15.
29. Les F, Venditti A, Cásedas G, Frezza C, Guiso M, Sciubba F, et al. Everlasting flower (Helichrysum stoechas Moench) as a potential source of bioactive molecules with antiproliferative, antioxidant, antidiabetic and neuroprotective properties. Ind Crops Prod 2017;108:295-302.
30. Kanase V, Shaikh S. A pharmacognostic and pharmacological review on Chromolaena odorata (Siam weed). Asian J Pharm Clin Res 2018;11:34-8.
31. Amuthan A, Devi V, Shreedhara CS, Rao V, Puri K, Jasphin S. Vernonia cinerea (neichittikeerai) regenerates proximal tubules in cisplatin induced renal damage in mice. Asian J Pharm Clin Res 2019;12:332-5.
32. Ashraf K. An updated phytochemical and pharmacological review on Gynura procumbens. Asian J Pharm Clin Res 2019;12:9-14.
33. Maharana L, Sethi MK, Dash RN, Pattnaik S. Evaluation of antidiabetic and antihyperlipidemic effect of Vernonia divergens in streptozotocin-induced diabetic rats. Asian J Pharm Clin Res 2019;12:104-10.
34. Malik AY, Singh DP. Ethnobotanical and ethnoveterinary importance of plants of scrub areas of Dachigam national park, Jammu and Kashmir, India. Asian J Pharm Clin Res 2019;12:582-6.
35. Radha A, Puri S, Kumar S. An ethnobotanical study of wild medicinal plants used by migratory shepherds: A tribal community of Western Himalayas. Asian J Pharm Clin Res 2019;12:137-44.
36. Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu Medicinal Plants: An Inventory. Pietermaritzburg: University of Natal Press; 1996.
37. Swanepoel DP. The Medicinal Value of the Southern African Asteraceae. MSc Dissertation. Pretoria: University of Pretoria; 1997.
38. Neuwinger HD. African Ethnobotany: Poisons and Drugs. Weinheim: Chapman and Hall; 1996.
39. Williams VL, Balkwill K, Witkowski ET. Unraveling the commercial market for medicinal plants and plant parts on the Witwatersrand, South Africa. Econ Bot 2000;54:310-27.
40. Williams VL, Balkwill K, Witkowski ET. A lexicon of plants traded in the Witwatersrand umuthi shops. Bothalia 2001;31:71-98.
41. Arnold TH, Prentice CA, Hawker LC, Snyman EE, Tomalin M, Crouch NR, et al. Medicinal and Magical Plants of Southern Africa: An Annotated Checklist. Pretoria: National Botanical Institute; 2002.
42. Ero?lu HE, Aksoy A, Hamzao?lu E, Budak U, Albayrak S. Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture. Cytotechnology 2009;59:65-72.
43. Drewes SE. Natural products research in South Africa: 1890-2010. S Afr J Sci 2012;108:1-8.
44. Van Wyk BE, Oudtshoorn BV, Gericke N. Medicinal Plants of South Africa. Pretoria: Briza Publications; 2013.
45. Dilika F, Afolayan AJ, Meyer JJ. Comparative antibacterial activity of two Helichrysum species used in male circumcision in South Africa. S Afr J Bot 1997;63:158-9.
46. Germishuizen G, Meyer NL. Plants of Southern Africa: An Annotated Checklist. Strelitzia 14. Pretoria: National Botanical Institute; 2003.
47. Aiyegoro OA, Afolayan AJ, Okoh AI. In vitro antibacterial time kill studies of leaves extracts of Helichrysum longifolium. J Med Plant Res 2009;3:462-7.
48. Aiyegoro OA, Afolayan AJ, Okoh AI. In vitro antibacterial activities of crude extracts of the leaves of Helichrysum longifolium in combination with selected antibiotics. Afr J Pharm Pharmacol 2009;3:293-300.
49. Aiyegoro OA, Okoh AI. Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC. BMC Complement Alternat Med 2010;10:21.
50. Hilliard OM. Compositae in Natal. Pietermaritzburg: University of Natal Press; 1977.
51. Hilliard OM. Asteraceae. In: Leistner OA, editor. Flora of Southern Africa. Part 7 (Inuleae). Vol. 33. Pretoria: Botanical Research Institute; 1983. p. 1-325.
52. Manning JC, Goldblatt P. Plants of the Greater Cape Floristic Region 1: The Core Cape Flora. Cape Town: Strelitzia 29, South African National Biodiversity Institute; 2012.
53. Bandeira S, Bolnick D, Barbosa F. Wild Flowers of Southern Mozambique. Maputo: Universidade Eduardo Mondlane; 2007.
54. Hyde MA, Wursten BT, Ballings P, Palgrave MC. Flora of Mozambique: Species Information: Helichrysum longifolium DC; 2019. Available from: https://www.mozambiqueflora.com/ speciesdata/species.php?species_id=168540. [Last accessed on 2019 March 16].
55. Bhat RB, Jacobs TV. Traditional herbal medicine in Transkei. J Ethnopharmacol 1995;48:7-12.
56. Dilika NF, Nikolova RV, Jacobs TV. Plants used in the circumcision rites of the Xhosa tribe in South Africa. Acta Hortic 1995;426:165-70.
57. Dilika F, Meyer JJ. Antibacterial activity of Helicltrysum pedunculatum callus cultures. S Afr J Bot 1998;64:312-3.
58. Grierson DS, Afolayan AJ. An ethnobotanical study of plants used for the treatment of wounds in the Eastern Cape, South Africa. J Ethnopharmacol 1999;67:327-32.
59. Van Vuuren CJ, De Jongh M. Rituals of manhood in South Africa: Circumcision at the cutting edge of critical intervention. S Afr J Ethnol 1999;22:142-56.
60. Mathekga AD. Antimicrobial Activity of Helichrysum species and the Isolation of a New Phloroglucinol from Helichrysum caespititium. PhD Dissertation. Pretoria: University of Pretoria; 2001.
61. Dilika NF. The Medicinal Value of Amaryllidaceae and Asteraceae species used in Male Circumcision. PhD Thesis. Pretoria: University of Pretoria; 2002.
62. Swartz VG. Phytochemical Studies of Helichrysum patulum. MSc Dissertation. Cape Town: University of the Western Cape; 2006.
63. Reddy D. The Phytochemistry and Antimicrobial Activity of Selected Indigenous Helichrysum species. MSc Dissertation. Johannesburg: University of the Witwatersrand; 2007.
64. Bolofo RN, Johnson CT. The identification of ‘isicakathi’ and its medicinal use in Transkei. Bothalia 1988;18:125-30.
65. Lourens AC. Structural and Synthetic Studies of Sesquiterpenoids and Flavonoids isolated from Helichrysum species. PhD Thesis. Pietermaritzburg: KwaZulu-Natal University; 2008.
66. Nqeketo A. Xhosa Male Circumcision at the Crossroads: Responses by Government, Traditional Authorities and Communities to Circumcision Related Injuries and Deaths in Eastern Cape Province. MSc Dissertation. Cape Town: University of the Western Cape; 2008.
67. Aiyegoro OA, Afolayan AJ, Okoh AI. Studies on the in vitro time-kill assessment of crude aqueous and acetone extracts of Helichrysum pedunculatum leaves. Afr J Biotechnol 2008;7:3721-5.
68. Aiyegoro OA, Afolayan AJ, Okoh AI. In vitro time-kill assessment of crude methanol extract of Helichrysum pedunculatum leaves. Afr J Biotechnol 2008;7:1684-8.
69. Aiyegoro OA, Afolayan AJ, Okoh AI. Synergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria. Biol Res 2009;42:327-38.
70. Aiyegoro OA, Afolayan AJ, Okoh AI. In vitro evaluation of the interactions between crude leaf extracts of Helichrysum pedunculatum and some antibiotics. Afr J Tradit Complement Alternat Med 2009;6:408.
71. Fearon JJ. Population Assessments of Priority Plant Species used by Local Communities in and around Three Wild Coast Reserves, Eastern Cape, South Africa. MSc Dissertation. Grahamstown: Rhodes University; 2010.
72. Venter MA. Some views of Xhosa women regarding the initiation of their sons. Koers 2011;76:559-75.
73. Bhat RB. Medicinal plants and traditional practices of Xhosa people in the Transkei region of Eastern Cape, South Africa. Indian J Tradit Knowl 2014;13:292-8.
74. Sewani-Rusike CR, Mammen M. Medicinal plants used as home remedies: A family survey by first year medical students. Afr J Tradit Complement Altern Med 2014;11:67-72.
75. Suntar I. The medicinal value of Asteraceae family plants in terms of wound healing activity. FABAD J Pharm Sci 2014;39:21-31.
76. Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh: E and S Livingstone; 1962.
77. Hutchings A. Zulu Medicinal Plants. Pietermaritzburg: University of Natal Press; 1996.
78. Ncube NS. Anti-bacterial Properties of the Methanol Extract of Helichrysum pedunculatum. MSc Dissertation. Alice: University of Fort Hare; 2008.
79. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. ScientificWorldJournal 2013;2013:162750.
80. Marín M, Máñez S. Recent trends in the pharmacological activity of isoprenyl phenolics. Curr Med Chem 2013;20:272-9.
81. Aiyegoro OA, Okoh AI. Phytochemical screening and polyphenolic antioxidant activity of aqueous crude leaf extract of Helichrysum pedunculatum. Int J Mol Sci 2009;10:4990-5001.
82. Dilika F, Bremner PD, Meyer JJ. Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: A plant used during circumcision rites. Fitoterapia 2000;71:450-2.
83. Meyer JJ, Dilika F. Antibacterial activity of Helichrysum pedunculatum used in circumcision rites. J Ethnopharmacol 1996;53:51-4.
84. Eloff JN. It is possible to use herbarium specimens to screen for antibacterial components in some plants. J Ethnopharmacol 1999;67:355-60.
85. Aiyegoro OA, Afolayan AJ, Okoh AI. Interactions of antibiotics and extracts of Helichrysum pedunculatum against bacteria implicated in wound infections. Folia Microbiol (Praha) 2010;55:176-80.
86. Mokoka TA, Xolani PK, Zimmermann S, Hata Y, Adams M, Kaiser M, et al. Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II. Planta Med 2013;79:1380-4.
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ALFRED MAROYI. “HELICHRYSUM LONGIFOLIUM AND HELICHRYSUM PEDUNCULATUM: A COMPARATIVE ANALYSIS OF THEIR MEDICINAL USES, CHEMISTRY AND BIOLOGICAL ACTIVITIES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 7, May 2019, pp. 41-46, https://innovareacademics.in/journals/index.php/ajpcr/article/view/33684.
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