COAGULATION PROFILE IN PATIENTS SUFFERING FROM ACUTE BRUCELLOSIS
Objective: Although brucellosis has almost been eradicated from most of the developed countries, it still continues to be a major but somehow neglected disease in the developing and underdeveloped countries. In the past, hematological abnormalities like anemia, thrombocytopenia have been reported to be seen in brucellosis patients. The objective of the present study is to observe and study the coagulation profile of patients suffering from acute brucellosis.
Methods: Blood samples were collected from brucellosis patients and healthy volunteers and were analyzed in automated blood coagulation analyzer and automated hematology analyzer to find out the values of prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelet count.
Results: Statistical analysis revealed that there was marginal increase in the aPTT level and platelet count in brucellosis patients than that of the control patients.
Conclusion: The study revealed that there might be a tendency of prolonged aPTT and increase in platelet levels in brucellosis patients.
Keywords: Brucellosis, coagulation profile, prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count.
Corbel MJ. Brucellosis: an overview. Emerg Infect Dis. 1997;3:213â€“21.
Mohamed A El-Koumi, Mona Afify, Salha H Al-Zahrani. A Prospective Study of Brucellosis in Children: Relative Frequency of Pancytopenia. Mediterr J Hematol Infect Dis.2013; 5(1).
Corbel MJ ,Brucellosis in Humans and Animals , World Health Organization, 2006.
"Diagnosis and Management of Acute Brucellosis in Primary Care". Brucella Subgroup of the Northern Ireland Regional Zoonoses Group. August 2004.
Atluri V L, Xavier M N, De Jong M F, Den Hartigh A B, Tsolis R E M . Interactions of the Human Pathogenic Brucella Species with Their Hosts. Annual Review of Microbiology , 2011, 65: 523â€“541.
"Ireland free of brucellosis". RTÃ‰. 2009-07-01.
Rizzo Naudi, John . Brucellosis, the Malta Experience. Malta: Publishers Enterprises group (PEG) Ltd. 2005.
"MAF Biosecurity New Zealand: Brucellosis". Ministry of Agriculture and Forestry of New Zealand.
"Queensland Health: Brucellosisâ€, State of Queensland (Queensland Health). 2010-11-24.
Lehane, Robert . Beating the Odds in a Big Country: The eradication of bovine brucellosis and tuberculosis in Australia, CSIRO PUBLISHING, 1996.
Fischbach, F T and Dunning, M B . A manual of laboratory and diagnostic tests, Lippincott Williams and Wilkins, 2008.
Akdeniz H, Irmak H, SeÃ§kinli T, Buzgan T, and DemirÃ¶z A P, Hematological manifestations in brucellosis cases in Turkey, Acta Medica Okayama, 1998,52 :1, 63â€“65..
Fretin, D A.-B. Brucella suis identification and biovar typing by real-time PCR. Veterinary Microbiology, 2008, 131 (2-4), 376-385.
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