• MAHAVEER SING Department of Pharmacy, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
  • SRAVAN KUMAR P Department of Pharmacy, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
  • BIRENDRA SHRIVASTAVA Department of Pharmacy, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
  • PAMULA REDDY B Department of Pharmacy, School of Pharmacy, Guru Nanak Group of Institutions, Hyderabad, Telangana, India.


Celosia cristata (CC) is used in traditional medicine to cure several disorders. It is a member of the genus Celosia and is commonly known as cockscomb, since the flower looks like the head on a rooster. Many sensitive ingredients were isolated from different parts of the plant. The recent studies showed that the plant exerted a wide range of pharmacological activities. The chemical constituents and pharmacological activities of CC were presented in this review.

Keywords: Celosia cristata, cockscomb, chemical constituent


1. Rubini D, Sudhahar D, Anandarajagopal K. Phytochemical investigation and anthelmintic activity of Celosia cristata. IRJP 2012;3:335-7.
2. Surse SN, Shrivastava B, Sharma P, Sharma J, Gide PS. Pharmacognostic standardisation of whole plant of Celosia argentea, var. Cristata (L). Int J Pharm Res Sch 2014;3:2277-7873.
3. De Bao W. Da G, Jie XY, Qin W. The nutritional components of Celosia cristata L cv plumosa. J Plant Resour Environ 1994;3:32-5.
4. Woo K, Ko J, Song S, Lee J, Kang J, Seo M, et al. Antioxidant compounds and antioxidant activities of the methanolic extracts from cockscome (Celosia cristata L.) flowers. Planta Med 2011;77:77-8.
5. Yaolin W, Tofazzal I, Satoshi T. Phenolic constituents of Celosia cristata L. susceptibleto Spinach root rot pathogen Aphanomyces cochlioides. Biotechnol Biochem 2010;70:2567-70.
6. Wang Y, Lou Z, Wu QB, Guo ML. A novel hepatoprotective saponin from Celosia cristata L. Fitoterapia 2010;81:1246-52.
7. Sun ZL, Gao GL, Xia YF, Feng J, Qiao ZY. A new hepoprotective saponin from semen Celosia cristata. Fitoterapia 2011;82:591-4.
8. Gholizadeh A, Kapoor HC. Modifications in the purification protocol of Celosia cristata antiviral proteins lead to protein that can be N-terminally sequenced. Protein Pept Lett 2004;11:551-61.
9. Wang Y. Chemical Constituents and Bioactivities of Celosia Cristata L. and Penthorum Chinense Pursh, Ph D Thesis. China: Second Military Medical University; 2012.
10. Kim YS, Hwang JW, Sung SH, Jeon YJ, Jeong JH, Jeon BT, et al. Antioxidant activity and protective effect of extract of Celosia cristata L. flower on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Food Chem 2015;68:572-9.
11. Herrmann F, Romero MR, Blazquez AG, Kaufmann D, Ashour ML, Kahl S, et al. Diversity of pharmacological properties in Chinese and European medicinal plants: Cytotoxicity, antiviral and antitrypanosomal screening of 82 herbal drugs. Diversity 2011;3:547-80.
12. Pyo YH, Yoon MY, Son JH, Cho TB. The effect of Celosia cristata L. Ethanol extract on anti-oxidant and anti-aging activity. Korean J Biotechnol Bioeng 2008;23:431-8.
13. Wen Y, Islam MT, Tahara S. Phenolic constituents of Celosia cristata L. Susceptible to Spinach root rot pathogen Aphanomyces cochlioides. Biosci Biotechnol Biochem 2006;70:2567-70.
14. Fitoussi R, Estève D, Delassus A, Vié K. Impact of Celosia cristata extract on adipogenesis of native human CD34+/CD31-cells. JCDSA 2013;3:55-63.
15. Jayanthy V, Shafna A. Use of flowers as antimelanocyte agent against UV radiation effects. Am J Biopharm Biochem Life Sci 2012;1:A068.
16. Yun SM, Choi BH, Ku HO, Lee MH, Nam HM, Lee KJ, et al. Antimicrobial activities of the flower extract of Celosia cristata L. Planta Med 2008;74:PA31.
17. Baranwal VK, Verma HN. Localized resistance against virus infection by leaf extract of Celosia cristata. Plant Pathol 1998;41:633-8.
18. Balasubrahmanyam A, Baranwal VK, Lodha ML, Varma A, Kapoor HC. Purification and properties of growth stage-dependent antiviral proteins from the leaves of Celosia cristata. Plant Sci 2000;154:13-21.
19. Hamzah RU, Lawal AR, Madaki FM, Erukainure OL. Methanolic extract of Celosia argentea var. Crista leaves modulates glucose homeostasis and abates oxidative hepatic injury in diabetic rats. Comp Clin Pathol 2018;27:1065-71.
20. Shanta I, Shafiullah SM, Ahmed T. Antinociceptive effect of methanol extract of Celosia cristata Linn. In mice. BMC Complement Altern Med 2016;16:400.
21. Gholizadeh A, Kumar M, Balasubrahmanyam A, Sharma S, Narwal S, Lodha ML. Antioxidant activity of antiviral proteins from Celosia cristata. J Plant Biochem Biotechnol 2004;13:13-8.
22. Rajendran R. Preliminary phytochemical analysis and anti-bacterial activity of Mimosa pudica Linn leaves. JGPT 2009;1:76.
23. Balick JM, Cox PA. Plants, People and Culture: The Science of Ethnobotany. New York: Scientific American Library; 1996. p. 228.
24. Jagtap NS, Khadabadi SS, Ghorpade DS, Banarase NB, Naphade SS. Antimicrobial and antifungal activity of Centella asiatica (L.) Urban. Umbeliferae Res J Pharm Tech 2009;2:328-30.
25. Wijesekera RB. Plant derived medicines and their role in global health. In: The Medicinal Plant Industry. United States: CRC Press; 1991.
26. Chitravadivu C, Bhoopathi M, Balakrishnan V, Elavazhagan T, Jayakumar S. Antimicrobial activity of laehiums prepared by herbal venders, South India. Am Eur J Sci Res 2009;4:142-7.
27. Mohammed R, Das AK, Ariful M, Mollik H, Jahan R, Khan M, et al. An ethnomedicinal survey of Dhamrai Sub-district in Dhaka district, Bangladesh. Am Eur J Sust Agric 2009;3:881-8.
28. Dana E, Sanz-Elorza M, Sobrino E. Plant Invaders in Spain (Check-list); 2003. Available from: http://www.med-alienplants.org/checklist.
29. Norazaidah AY, Hainida EK. Antioxidant activity and phenolic content of raw and blanched Amaranthus species. Food Chem 2006;94:47-52.
30. Roriz CL, Barros L, Carvalho AM, Santos-Buelga C, Ferreira IC. Pterospartum tridentatum, Gomphrena globosa and Cymbopogon citratus: A phytochemical study focused on antioxidant compounds. Food Res Int 2014;62:684-93.
31. Salvador MJ, Ferreira EO, Mertens-Talcott SU, De Castro WV, Butterweck V. Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla. Z Naturforsch C J Biosci 2006;61:19-25.
32. Salvador MJ, Pereira PS, França SC, Candido RC, Ito IY. Bioactive chemical constituents and comparative antimicrobial activity of callus culture and adult plant extracts from Alternanthera tenella. Z Naturforsch C J Biosci 2009;64:373-81.
33. Biella CA, Salvador MJ, Dias DA, Dias-Baruffi M, Crotti LS. Evaluation of immunomodulatory and antiinflammatory effects and phytochemical screening of Alternanthera tenella Colla (Amaranthaceae) aqueous extracts. Memorias Inst Oswaldo Cruz 2008;103:569-77.
34. Teixeira CG, Piccoli A, Costa P, Soares L, Da Silva-Santos JE. Involvement of the nitric oxide/soluble guanylate cyclase pathway in the antioedematogenic action of Pfaffia glomerata (Spreng) Pedersen in mice. J Pharm Pharmacol 2006;58:667-75.
35. Freitas CS, Baggio CH, Da Silva-Santos JE, Rieck L, de Moraes Santos CA. Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng) Pedersen, Amaranthaceae, in rats. Life Sci 2004;74:1167-79.
36. Sanoko R, Esperanza G, Pizza C, De Tommasi N. Triterpene saponins from Alternanthera repens. Phytochemistry 1999;51:1043-47.
37. Wang P, Li S, Ownby S, Zhang Z, Yuan W. Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana. Phytochemistry 2009;70:430-6.
38. Cai Y, Sun M, Corke H. Antioxidant activity of betalains from plants of the Amaranthaceae. J Agric Food Chem 2003;51:2288-94.
39. Liu H, Cao J, Jiang W. Evaluation of physiochemical and antioxidant activity changes during fruit on-tree ripening for the potential values of unripe peaches. Sci Horticult 2015;193:32-9.
40. Souza JG, Tomei RR, Kanashiro A, Kabeya LM, Azzolini AE. Ethanolic crude extract and flavonoids isolated from Alternanthera maritima: Neutrophil chemiluminescence inhibition and free radical scavenging activity. Z Naturforsch C J Biosci 2007;62:339-47.
41. Simpson MG. Plant Systematics. 2nd ed. United States: Academic Press, Elsevier; 2010. p. 301-2.
42. Uusiku NP, Oelofse A, Duodu KG, Bester MJ, Faber M. Nutritional value of leafy vegetables of Sub-Saharan Africa and their potential contribution to human health: A review. J Food Compos Anal 2010;23:499-509.
43. Koh HL, Chua TK, Tan CH. A Guide to Medicinal Plant, an Illustrated, Scientific and Medicinal Approach. Singapore: World Scientific; 2009. p. 292.
44. Wee YC. A Guide to Medicinal Plants. Singapore: Singapore Science Centre Publication; 1992.
45. The National Academies Press. Lost Crops of Africa. Vol. 2. Washington, DC: The National Academies Press; 2006.
46. Haya F, Nirit B, Moshe B, Ilona R, Zeev BN, Atara Z. Application of secondary-treated effluents for cultivation of sunflower (Helianthus annuus L.) and celosia (Celosia argentea L.) as cut flowers. Sci Horticult 2007;115:62-9.
47. Etkin NL. Medicinal cuisines: Diet and ethnopharmacology. Int J Pharmacogn 1996;34:313-26.
48. Pieroni A. Medicinal plants and food medicines in the folk traditional of the upper Lucca Province, Italy. J Ethnopharmacol 2000;70:235-7.
49. Wiart C. Medicinal Plants of Southeast Asia. Malaysia: Pelanduk Publications; 2000.
50. Nidavani RB, Mahalakshmi AM, Seema M, Krishna KL. Pharmacology of Celosia argentea L. J Atoms Mol 2014;4:635-44.
51. Jagtap SD, Deokule SS, Pawar PK, Harsulkar AM. Traditional ethnomedicinal knowledge confined to the Pawra tribe of Satpura hills, Maharashtra, India. Ethnob Leaf 2009;13:98-115.
52. Vetrichelvan T, Jegadeesan M, Devi B. Anti-diabetic activity of alcoholic extract of Celosia argentea LINN seeds in rats. Biol Pharm Bull 2002;25:526-8.
53. Li S, Long C, Liu F, Lee S, Guo Q, Li R, et al. Herbs for medicinal baths among the traditional Yao communities of China. J Ethnopharmacol 2006;108:59-67.
54. Ticktin T, Dalle SP. Medicinal plant use in the practice of midwifery in rural Honduras. J Ethnopharmacol 2005;96:233-48.
55. Grosvenor PW, Supriono A, Gray DO. Medicinal plants from Riau Province, Sumatra, Indonesia. Part 2: Antibacterial and antifungal activity. J Ethnopharmacol 1995;45:97-111.
56. Dung N, Loi DT. Selection of traditional medicines for study. J Ethnopharmacol 1991;32:57-70.
57. Chen CP, Lin CC, Tsuneo N. Screening of Taiwanese crude drugs for antibacterial activity against Streptococcus mutans. J Ethnopharmacol 1989;27:285-95.
58. Houghton PJ, Osibogun IM. Flowering plants used against snakebite. J Ethnopharmacol 1993;39:1-29.
59. Grubben GJ, Denton OA. Plant Resources of Tropical Africa 2. Vegetables. Wageningen, Leiden: PROTA Foundation, Backhuys, CTA; 2004.
60. Omonike OO, Adebayo AG, Edith OA. Ethnobotanical survey of plants used in treatment of inflammatory diseases in Ogun state of Nigeria. Eur J Sci Res 2010;43:183-91.
61. Padal SB, Murty PP, Rao DS, Venkaiah M. Ethnomedicinal plants from Paderu division of Visakhapatnam district, A.P, India. J Phytol 2010;2:70-91.
62. Markandeya AG, Firke NP, Pingale SS, Gawale SS. Quantitative elemental analysis of Celosia argentea leaves by ICP-OES techniques using different digestion methods. Int J Chem Anal Sci 2013;4:175-81.
63. Patil HM, Bhaskar VV. Medicinal uses of plants by tribal medicine men of Nandurbar district in Maharashtra. Natl Prod Radiance 2006;5:125-30.
64. Anonymous. The Wealth of India. New Delhi: CSIR; 1992. p. 414-5.
65. Hase K, Kadota S, Basnet P. Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. Planta Med 1997;63:216-9.
66. Vetrichelvan T, Jegadeesan M. Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea. Indian Drugs 2000;37:286-8.
67. Hase K, Kadota S, Basnet P, Takahashi T, Namba T. Research article hepatoprotective effects of traditional medicines. Phytother Res 1996a;10:387-92.
68. Haribabu S, Adupa SK. Phytochemical screening and hepatoprotective activity of Celosia argentea Linn. J Pharm Res 2014;8:405-9.
69. Jain A, Katewa SS, Galav PK, Sharma P. Medicinal plant diversity of Sitamata wildlife sanctuary, Rajasthan, India. J Ethnopharmacol 2005;102:143-57.
70. Katewa SS, Chaudhary BL, Jain A. Folk herbal medicines from tribal area of Rajasthan, India. J Ethnopharmacol 2004;94:41-6.
71. Rajendra MK, Nitin BG, Nanasaheb PD, Mangesh MK, Sudhir MV, Sneha AK. Use of Celosia argentea Linn aqueous flower extract as a natural indicator in acid base titration. Int J PharmTech Res 2014;6:80-3.
72. Hayakawa Y, Fujii H, Hase K, Ohnishi Y, Sakukawa R, Kadota S, et al. Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds. Biol Pharm Bull 1998;21:1154-59.
73. Devhare SV, Nirmal SA, Rub RA, Dhasade VV, Zaware BB, Mandal SC. Immunomodulating activity of Celosia argentea Linn aerial parts. Lat Am J Pharm 2011;30:168-71.
74. Gbadamosi IT, Alia AE, Okolosi O. In-vitro antimicrobial activities and nutritional assessment of roots of ten Nigerian vegetables. N Y Sci J 2012;5:234-40.
75. Diéméléou CA, Zoué LT, Niamké SL. Antioxidant and antifungal properties of seed oils extracted from three leafy vegetables plants consumed in Côte d’Ivoire. J Nat Prod Plant Resour 2013;3:7-13.
76. Eseoghene O, Kola’ KA. Antimicrobial activity of Celosia argentea L. Amaranthaceae. Am J Res Commun 2015;3:123-33.
77. Bhujbal SS, Chitlange SS, Suralkar AA, Shinde DB, Patil MJ. Anti-inflammatory activity of an isolated flavonoid fraction from Celosia argentea Linn. J Med Plants Res 2008;2:52-4.
78. Qingbin W, Yan W, Meili G. Triterpenoid, saponins from the seeds of Celosia argentea and their anti-inflammatory and antitumor activities. Chem Pharm Bull 2011;59:666-71.
79. Joshi PC, Patil SA, Sambrekar SN. Evalution of antiurolithiatic activity of ethanolic extract of Celosia argentea (seed) in rats. Univ J Pharm 2012;1:52-60.
80. Malomo SO, Ore A, Yakubu MT. In vitro and in vivo antioxidant activities of the aqueous extract of Celosia argentea leaves. Indian J Pharmacol 2011;43:278-85.
81. Dalimartha S. Atlas Tumbuthan Obat Indonesia. Jakarta: Niaga Swadaya; 2007. p. 2-4.
82. Wu JN. An Illustrated Chinese Materia Midica. Oxford: Oxford University Press; 2005. p. 168.
83. Ashok KC, Divya Sree MS, Joshna A, Mohana LS, Satheesh KD. A review on South Indian edible leafy vegetables. J Glob Trends Pharm Sci 2013;4:1248-56.
84. Ying T, Hai-Liang X, Mei-Li G. Review on research of the phytochemistry and pharmacological activities of Celosia argentea. Rev Bras Farmacogn 2016;26:787-96.
85. Jun’ichi K, Hayato S, Kazutaka S, Koichi T, Hiroshi M. Celogentins AC. New antimitotic bicyclic peptides from the seeds of Celosia argentea. J Org Chem 2001;66:6626-33.
86. Cai Y, Sun M, Schliemann W, Corke H. Chemical stability and colorant properties of betaxanthin pigments from Celosia argentea. J Agric Food Chem 2001;49:4429-35.
87. Schliemann W, Cai Y, Degenkolb T, Schmidt J, Corke H. Betalains of Celosia argentea. Phytochemistry 2001;58:159-65.
88. Morita H, Suzuki H, Kobayashi J. Celogenamide A, a new cyclic peptide from the seeds of Celosia argentea. J Nat Prod 2004;67:1628-30.
89. Xue Q, Suna ZL, Guo ML, Ying W, Zhang G, Wang XL. Two new compounds from semen Celosiae and their protective effects against CCl4-induced hepatotoxicity. Natl Prod Res 2011;25:772-80.
90. Satyanarayana V. Preliminary phytochemical screening and TLC profile of selected four plants of Tirupati hills in Chitoor district, Andhra Pradesh. J Pharmacogn Phytochem 2016;5:259-64.
91. Satyavathi K, Lakshmi KK, Prasenjit M, De A, Jana S, Aneela S. Evaluation of anthelmintic activity of Carica Papaya Latex using pheritima posthuma anthelmintic activity. Pharm Sci 2012;2:10-2.
92. Neha S. Anthelmintic activity of extracts of some medicinal plants. Int J Comput Sci Mathe 2011;3:183-7.
93. Ojieh AE, Adegor EC, Lawrence EO. Preliminary phytochemical screening, analgesic and anti-inflammatory properties of Celosia Isertii. Eur J Med Plants 2013;3:369-80.
94. Harborne JB. A Guide to Modern Technique of Plant Analysis. London: Chapman and Hill; 1973. p. 279.
95. Brain KR, Turner TD. Practical Evaluation of Phytopharmaceuticals. 1st ed. Bristol: Wright-Scientechnica; 2013. p. 69-380.
96. Mythili1 T, Ravindhran R. Phytochemical screening and antimicrobial activity of Sesbania sesban (L.) Merr. Asian J Pharm Clin Res 2012;5:179-82.
97. Hacene E. Effect of prodigiosin from Serratia marcescens br1 strain as an antioxidative, antimicrobial, and in vivo wound healing. Asian J Pharm Clin Res 2020;13:175-9.
18 Views | 17 Downloads
How to Cite
SING, M., S. KUMAR P, B. SHRIVASTAVA, and P. REDDY B. “A COMPREHENSIVE REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL OVERVIEW ON CELOSIA CRISTATA FOR FUTURE PROSPECTIVE RESEARCH”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 12, Dec. 2020, pp. 21-24, doi:10.22159/ajpcr.2020.v13i12.38675.
Review Article(s)