ASSESSMENT OF LEVELS OF LIPID PROFILE, APOLIPOPROTEINS, AND ATHEROGENIC INDEX IN CORD BLOOD OF NEONATES ACCORDING TO GESTATIONAL AGE
Keywords:Cord blood, Atherogenic index, Gestational age, Correlation
Background: A considerable amount of cholesterol is needed by human body for the maintenance of tissue and various bodily metabolisms. Cardiac disorders are major cause for morbidity and mortality in recent years. Cord blood lipoprotein is influenced by factors such as placental insufficiency, mode of delivery, and conditions affecting fetal growth. The present study was planned to analyze cord blood lipid profile, apolipoproteins, and atherogenic index in different gestational age and compare them gender wise.
Methods: A cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Geetanjali Medical College and Hospital, Udaipur. The study group included 640 neonates, divided into two groups on the basis of gestational age into near-term neonates (34–37 weeks) and term neonates (>37 weeks). The cord blood samples were taken from placental side of umbilical cord at birth. The blood was tested to determine lipid profile, apolipoproteins, and atherogenic index.
Results: The results showed total cholesterol, triglyceride, HDL-C, LDL-C, ApoA-1, and Apo B level higher in near-term neonates group than term neonates. TC, TG, HDL-C, VLDL-C, and apolipoprotein A-1 were negatively correlated but LDL-C and apolipoprotein B were positively correlated with gestational age.
Conclusion: The study showed that the gestational age is associated with lipid parameters. Prematurity as a factor was associated with atherogenic index.
Rifai N, Bachorik PS, Albers JJ. lipids, lipoproteins and apolipoproteins. In: Carl AB, Edward RA, editors. Teitz Textbook of Clinical Chemistry. 3rd ed. USA: WB Saunders; 1999. p. 826-30.
Antman EM. Selwyn AP, Braunwald E, Lascalzo J. Ischemic heart diseases. Harrison’s Principles of Internal Medicine. 18th ed. Newyork: Mc Graw Hill companies; 2012. p. 1998.
Avinash NJ, Arun KT, Swati AT. Lipid profile of umbilical cord blood of near term and term neonates. Int J Curr Med Appl Sci 2014;2:1-11.
Klag MJ Ford DE, Mead LA. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993;328:13-8.
Jain S, Sogani S. Evaluation of lipid profile and apolipoproteins in cord blood from tribal and non-tribal population of Udaipur region, India. IJRCOG 2015;4:1-6.
Sattar N, Williams K, Siriderman AD, Agostino RB, Haffner SM. Comparison of the associations of apolipoprotein B and no highdensity lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the insulin resistance atherosclerosis study. Circulation 2004;110:2687-93.
Friedelwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
Dati F. Estimation of apolipoproteins by immunoturbidimetric method. Lab Med 1989;13:87-9.
Diaz M, Leap C, Raman Y, Cajal J, Jimenez MD, Martinez H, et al. Cord blood lipoprotein-cholesterol: Relationship between birth weight and gestational age of newborns. Metabolism 1989;38:435-8.
Sreekarthik KP, Shubha J, Arvind K, Sumana S. A study of cord blood lipid profile in preterm and term neonates. Int J Appl Res 2015;1:276-81.
Spear ML, Amer S, Hamosh M, Pereire GR, Lorcoran LG, Hamosh P. Lecithin: Cholesterol acyl transferase (LCAT) activity during lipid infusion in premature infants. J Pediatr Gestroenterol Nutr 1991;13:72-6.
Parker CR Jr., Simpson ER, Bilheimer DW, Leveno K, Carr BR, MacDonald PC. Inverse relation between low density lipoprotein cholesterol and dehydroisoandrosterone sulphate in human fetal plasma. Science 1980;208:512-4.
Pardo IM, Geloneze B, Tambascia MA, Barros-Filho AA. Atherogenic lipid profile of Brazilian near term newborns. Braz J Med Res 2005;38:755-60.
Youenzawa R, Okada T, Kitamura T, Fujita H, Inami I, Makimoto M, et al. Very low density lipoprotein in the cord blood of preterm neonates. Metabolism 2009;58:704-7.
Pecks U, Brieger M, Schiessi B, Bauerschlag DO, Piroth D, Bruno B, et al. Maternal and fetal cord blood lipids in intrauterine growth restriction. J Perinat Med 2012;40:287-96.
Irving RJ, Belton NR, Elton RA, Walker BR. Adult cardiovascular risk factors in premature babies. Lancet 2000;355:2135-6.
Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull 2008;29:520-34.
Kharb S, Kaur A, Nanda S. Comparison of cord blood atherogenic index in males and females. Iran Cardiovasc Res J 2010;4:35-8.
Nayak CD, Agarwal V, Nayak DM. Correlation of cord blood lipid heterogeneity in neonates with their anthropometry at birth. Indian J Clin Biochem 2013;28:152-7.
Fosbrooke AS, Wharton BA. Plasma lipids in umbilical cord blood from infants of normal and low birth weight. Biol Neonate 1973;23:330-5.
Huter O, Brezinka C, Drexel H, Patsch TR. Cord blood lipids with lipoproteins in small appropriate and large for gestational age neonates born to non-dibetic mothers. J Matern Feta Invest 1997;7:172-4.
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