• ABHA SAMAR Department of Obstetrics and Gynaecology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
  • RAJENDRA SAMAR Department of General Medicine, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
  • SUMAN JAIN Department of Biochemistry, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.



Cord blood, Maternal serum, Neonates, Lipid profile, Atherogenic index


Background: One of the leading causes of morbidity and mortality in the modern period is coronary heart disease. The fetal origin concept has shown that the origins of this epidemic can be found as early as fetal life. A few research have compared the lipid profiles of cord blood from pre-term and term newborns, opening the door to early chronic disease prevention.

Aim: The aim of the study was to compare lipid parameters in pre-term and term maternal serum and neonatal cord blood.

Methods: In 300 newborns cord blood and 300 maternal serum samples, a cross-sectional research was performed. The placental side of the umbilical cord was used to collect cord blood samples, which were then examined for their lipid profiles, which included measurements of serum cholesterol, triglycerides, low density lipoprotein (LDL), high density lipoprotein (HDL), and apolipoproteins including ApoA and ApoB.

Results: When lipid parameters from maternal serum and neonatal cord blood were compared, maternal serum had statistically significant higher values for the apolipoproteins, atherogenic index (AI), and lipid profile. Lipid parameters (TC, TG, LDL, very low density lipoprotein, Apolipoprotein B, and AI) were higher in mothers of pre-term babies and also in cord blood of pre-term neonates. Comparison of lipid parameters of pre-term and term mothers and neonatal cord blood was highly significant.

Conclusion: There was a significant association of cord blood and maternal lipid parameters; hence, change in maternal lipid levels might influences the lipid levels in the cord blood of neonates.


Download data is not yet available.

Author Biography

RAJENDRA SAMAR, Department of General Medicine, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Associate Professor, Department of General Medicine,

Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.


McGaw T. Peridontal disease and pre term delivery of low birth weight infants. J Can Dent Assoc 2002;68:165-9.

Barker DJ. The intrauterine origins of cardiovascular disease. Acta Paediatr Suppl 1993;82:93-9. doi: 10.1111/j.1651-2227.1993. tb12938.x, PMID 8219485

Avinash NJ, Arun KT, Swati AT. Lipid profile of umbilical cord blood of near term and term neonates. Int J Ournal Curr Med Appl Sci 2014;2:1-11.

Klag MJ, Ford DE, Mead LA. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993;328:13-8.

Jain S, Sogani S. Evaluation of lipid profile and apolipoproteins in cord blood from tribal and non-tribal population of Udaipur region, India. Int J Reprod Contracept Obstet Gynecol 2015;4:1-6.

Jain S, Bansal P, Prajapat R, Jadeja H. Evaluation of some minerals and vitamins in cord blood from rural and urban population of Udaipur REGION. Asian J Pharm Clin Res 2021;14:90-2. doi: 10.22159/ ajpcr.2021.v14i7.41909

Sattar N, Williams K, Sniderman AD, D’Agostino R, Haffner SM. Comparison of the associations of apolipoprotein B and no highdensity lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the insulin resistance atherosclerosis study. Circulation 2004;110:2687-93. doi: 10.1161/01. CIR.0000145660.60487.94, PMID 15492304

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502. doi: 10.1093/clinchem/18.6.499, PMID 4337382

Dati F. Estimation of apolipoproteins by immunoturbidimetric method. Lab Med 1989;13:87-9.

Pardo IM, Geloneze B, Tambascia MA, Barros-Filho AA. Atherogenic, lipid profile of Brazilian near-term newborns. Braz J Med Biol Res 2005;38:755-60.

Samar R, Mehta S, Paliwal A, Purohit C, Jain S. Assessment of levels of lipid profile, apolipoproteins and atherogenic index in cord blood of neonates according to gestational age. Asian J Pharm Clin Res 2022;15:46130.

Alvarez JJ, Montelongo A, Iglesias A, Lasunción MA, Herrera E. Longitudinal study on lipoprotein profile, high density lipoprotein subclass and postheparin lipases during gestation in women. J Lipid Res 1996;37:299-308. doi: 10.1016/S0022-2275(20)37617-3, PMID 9026528

William AN. Metabolic disease. In: Kiligman RM, editor. Nelson Textbook of Pediatrics. Philadelphia, PA: Saunders; 2007. p. 580-93.

Averna MR, Barbagallo CM, Dipaola G, Labisi M, Pinna G, Marino G. Lipids lipoproteins and apolipoproteins AI, AII, B, CI, CIII and E in newborns. Neonatology 1995;60:187-92.

Vaziri Esfarjani SH, Iravani E. Comparison of lipids and lipoprotein levels if cord blood in neonates in Ahwaj city with the same in Nelson textbook of paediatrics. J Kerman Univ Med Sci 2014;11:46343.

Jolly M, Sebire N, Harris J, Robinson S, Regan L. The risks associated with pregnancy in women aged 35 years or older. Hum Reprod 2000;15:2433-7. doi: 10.1093/humrep/15.11.2433, PMID 11056148

Gunderson E, Whitmer R, Lwis C, Queensberry C, West D, Sidney S. Do long term HDL-C declines association with a first birth vary by apoE phenotype? The coronary artery risk development in young adults (CARDIA) Study. J Women Health 2005;14:917-28.



How to Cite

SAMAR, A., R. SAMAR, and S. JAIN. “COMPARISON OF LIPID PARAMETERS IN MATERNAL SERUM AND NEWBORN CORD BLOOD”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 11, Nov. 2022, pp. 94-97, doi:10.22159/ajpcr.2022.v15i11.46343.



Original Article(s)