A COMPARATIVE STUDY OF NEUROPROTECTIVE EFFECT OF TELMISARTAN AND DONEPEZIL AGAINST LIPOPOLYSACCHARIDE INDUCED NEUROINFLAMMATION IN MICE
Objective: The aim of the present study was a comparative study of neuroprotective effect of telmisartan and donepezil against lipopolysaccharide
(LPS)-induced neuroinflammation in mice.
Methods: In this study, we investigated the comparative effect of telmisartan (5 mg/kg, p.o.) and donepezil (5 mg/kg, p.o.) in systemic inflammation
induced by LPS, ibuprofen (40 mg/kg, p.o.) was used as standard. Mice were treated with a single i.c. injection of LPS (5 Âµg/5 Âµl/kg), after 7 days
the animal behavior was evaluated by testing specific cognitive functions, on Morris water maze and Pole climbing test. Biochemical estimation for
glutathione (GSH), malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-Î±) was done by enzyme-linked immunosorbent assay plate reader.
Results: The neuroprotective effect of telmisartan (5 mg/kg) and donepezil (5 mg/kg) in LPS induced neuroinflammation in mice was compared. Oral
administration of telmisartan (5 mg/kg) for 7 days shows a better result in Morris water maze and pole climbing test, in comparison of donepezil. It
also increases the level of GSH and decreases the level of MDA and TNF-Î±
in mice brain.
Conclusion: The present study demonstrates that telmisartan and donepezil reduces LPS-induced microglial activation, beta-amyloid generation,
central nervous system cytokine production, and behavioral symptoms of sickness. In comparative study of telmisartan and donepezil, telmisartan
shows significant decrease in escape latency time and transfer latency time in comparison of donepezil. Therefore, telmisartan is more effective as
the comparative of donepezil.
Keywords: Neuroprotective, Telmisartan, Donepezil, Lipopolysaccharide-induced neuroinflammation.
Park SJ, Jung HJ, Son MS, Jung JM, Kim DH, Jung IH, et al.
Neuroprotective effects of INM-176 against lipopolysaccharide-induced
neuronal injury. Pharmacol Biochem Behav 2012;101(3):427-33.
Pintado C, Gavilan MP, Gavilan E, Garcia-Cuervo L, Gutierrez A,
Vitorica J, et al. Lipopolysaccharide-induced neuroinflammation
leads to the accumulation of ubiquitinated proteins and increases
susceptibility to neurodegeneration induced by proteasome inhibition
in rat hippocampus. J Neuroinflammation 2012;9(1):87.
Adams M, GmÃ¼nder F, Hamburger M. Plants traditionally used in
age related brain disorders â€“ a survey of ethnobotanical literature.
J Ethnopharmacol 2007;113(3):363-81.
Thompson WL, Karpus WJ, Van Eldik LJ. MCP-1-deficient
mice show reduced neuroinflammatory responses and increased
peripheral inflammatory responses to peripheral endotoxin insult.
J Neuroinflammation 2008;5:35.
Weiner HL, Frenkel D. Immunology and immunotherapy of Alzheimerâ€™s
disease. Nat Rev Immunol 2006;6(5):404-16.
Pang T, Wang J, Benicky J, SÃ¡nchez-Lemus E, Saavedra JM.
Telmisartan directly ameliorates the neuronal inflammatory response
to IL-1ÃŸ partly through the JNK/c-Jun and NADPH oxidase pathways.
J Neuroinflammation 2012;9:102.
Al-Hejjaj WK, Numan IT, Al-Saâ€™ad RZ, Hussain SA. Anti-inflammatory
activity of telmisartan in rat models of experimentally-induced chronic
inflammation: Comparative study with dexamethasone. Saudi Pharm J
Sumanth M, Sowmya H, Nagaraj SV, Narasimharaju K. Efficacy of
donepezil and galantamine in retrograde amnesia. Asian J Pharm Clin
Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, et al. Ibuprofen
suppresses plaque pathology and inflammation in a mouse model for
Alzheimerâ€™s disease. J Neurosci 2000;20(15):5709-14.
Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, et al. Neuroinflammation
by lipopolysaccharide causes
Asian J Pharm Clin Res, Vol 8, Issue 6, 2015, 68-72
Jawaid et al.
J Neuroinflammation 2008;5:37.
Joshi H, Parle M. Nootropic activity of calyces of Hibiscus sabdariffa
Linn. Iran J Pharmacol Ther 2006;5(1):15-20.
Jawaid T, Shakya AK, Siddiqui HH, Kamal M. Evaluation of
Cucurbita maxima extract against scopolamine-induced amnesia in
rats: Implication of tumour necrosis factor alpha. Z Naturforsch C
Dhir A, Akula KK, Kulkarni SK. Tiagabine, a GABA uptake
inhibitor, attenuates 3-nitropropionic acid-induced alterations
in various behavioral and biochemical parameters in rats. Prog
Neuropsychopharmacol Biol Psychiatry 2008;32(3):835-43.
Lee YJ, Choi DY, Choi IS, Kim KH, Kim YH, Kim HM, et al.
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharideinduced
inhibition of nuclear factor-kappaB
How to Cite
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.