PENETRATION TEST OF CAFFEINE IN ETHOSOME AND DESMOSOME GEL USING AN IN VITRO METHOD


Iskandarsyah Iskandarsyah, Alvina Wijaya Puteri, Ernysagita Ernysagita

Abstract


Objectives: Caffeine has many functions including its use in the field of cosmetics. Nonetheless, the percutaneous absorption of caffeine is very low
(9%), and the penetration of a substance such as caffeine in the skin is not desirable. Ethosomes and desmosomes are lipid vesicles created by the
modification of liposomes containing phospholipids and ethanol or dimethyl sulfoxide (DMSO) as the penetration enhancer. The purpose of this study
was to compare the effectiveness of ethosomes and desmosomes as vesicles in increasing the penetration of caffeine.
Methods: Ethosomes and desmosomes were prepared using phosphatidylcholine, ethanol/DMSO, and caffeine. Phosphatidylcholine was used in the
form of phospholipon 90 g that was obtained from soybeans. Observations were done including the characteristic of ethosomes and desmosomes,
organoleptic observation, homogeneity observation, and in vitro penetration test using Franz diffusion cell method.
Results: The cumulative penetration of caffeine ethosome gel is 3316.46±218.51 μg/cm2, with flux 249.45±30.06 μg·cm−2·hr−1, and 62.35±4.52%. The
cumulative penetration of the desmosome gel is 2954.95±222.87 μg/cm2 with flux 381.68±34.91 μg·cm−2·hr−1 and 53.4±3.65%.
Conclusions: It can be concluded that ethosome is more effective than desmosome in increasing the penetration of caffeine.


Keywords


Caffeine, Desmosome, Ethosome, Penetration study, Phosphatidylcholine, Penetration study, Thin-layer hydration.

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About this article

Title

PENETRATION TEST OF CAFFEINE IN ETHOSOME AND DESMOSOME GEL USING AN IN VITRO METHOD

Keywords

Caffeine, Desmosome, Ethosome, Penetration study, Phosphatidylcholine, Penetration study, Thin-layer hydration.

DOI

10.22159/ijap.2017.v9s1.69_76

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 120-123

Online ISSN

0975-7058

Statistics

9 Views | 19 Downloads

Authors & Affiliations

Iskandarsyah Iskandarsyah
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Alvina Wijaya Puteri
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Ernysagita Ernysagita
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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