• Amelia Luthfiah Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
  • Erny Sagita Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
  • Iskandarsyah Iskandarsyah Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.


Objectives: While p-synephrine exhibits lipolytic activity, it also has a low oral bioavailability as well as hydrophilic characteristic, so it is difficult for
it to penetrate the epidermis if it is made into transdermal preparation. The purpose of this research was to increase the penetration of p-synephrine
by preparing it as transfersome gel.
Materials and Methods: Three transfersome formulas were prepared—F1, F2, and F3—with the surfactants used at Tween 80, Span 80, and the
combination of Tween 80 and Span 80 with a ratio of 1:1, respectively.
Results: The results showed that F1 was the best formula, with the highest entrapment efficiency, of 64.058±0.754%, a particle size average of
103.3 nm, polydispersity index 0.269±0.05, and zeta potential of −36.2±0.64 mV, so this formula was employed for the gel formulation. Two gel
formulas were then prepared, transfersome gel (GT) and non transfersome gel (GNT).
Conclusions: The two gels were evaluated for their physical stability, and GT was found to be more stable than GNT.

Keywords: Transfersome, p-synephrine, Transdermal, Penetration in vitro test.


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How to Cite
Luthfiah, A., Sagita, E., & Iskandarsyah, I. (2017). PHYSICAL STABILITY TESTING OF P-SYNEPHRINE PREPARED AS TRANSFERSOME GEL. International Journal of Applied Pharmaceutics, 9, 124-126.
Original Article(s)