PHYSICAL STABILITY TESTING OF P-SYNEPHRINE PREPARED AS TRANSFERSOME GEL

  • Amelia Luthfiah Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
  • Erny Sagita Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
  • Iskandarsyah Iskandarsyah Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

Abstract

Objectives: While p-synephrine exhibits lipolytic activity, it also has a low oral bioavailability as well as hydrophilic characteristic, so it is difficult for
it to penetrate the epidermis if it is made into transdermal preparation. The purpose of this research was to increase the penetration of p-synephrine
by preparing it as transfersome gel.
Materials and Methods: Three transfersome formulas were prepared—F1, F2, and F3—with the surfactants used at Tween 80, Span 80, and the
combination of Tween 80 and Span 80 with a ratio of 1:1, respectively.
Results: The results showed that F1 was the best formula, with the highest entrapment efficiency, of 64.058±0.754%, a particle size average of
103.3 nm, polydispersity index 0.269±0.05, and zeta potential of −36.2±0.64 mV, so this formula was employed for the gel formulation. Two gel
formulas were then prepared, transfersome gel (GT) and non transfersome gel (GNT).
Conclusions: The two gels were evaluated for their physical stability, and GT was found to be more stable than GNT.

Keywords: Transfersome, p-synephrine, Transdermal, Penetration in vitro test.

References

1. WHO. Obesity and Overweight, Global Strategy on Diet, Physical
Activity and Health. Geneva: World Health Organization; 2003.
2. Park A. Human clinical research and therapeutics. J Invest Dermatol
2012;132(1):S85-96.
3. Djajadisastra J, Cholimi S, Hadyanti. Percutane transport profile
of caffeine and aminophyllinas anti-cellulite and the influences
of other substances on in vitro penetration. Int J Pharm Pharm Sci
2014;6(5):532-8.
4. Rossato LG, Costa VM, Limberger RP, Bastos Mde L, Remião F.
Synephrine: From trace concentrations to massive consumption in
weight-loss. Food Chem Toxicol 2011;49(1):8-16.
5. Shamma RN, Elsayed I. Transfersomal lyophilized gel of buspirone
HCl: Formulation, evaluation and statistical optimization. J Liposome
Res 2013;23(3):244-54.
6. Chaudhary H, Kohli K, Kumar V. Nano-transfersomes as a novel carrier
for transdermal delivery. Int J Pharm 2013;454(1):367-80.
7. Salager JL. Surfactants types and uses: Laboratory of formulation,
interfaces rheology and processes. J Am Oil Chem Soc
2002;65(6):1000-6.
8. Djajadisastra J. Cosmetic Stability. Jakarta: Presented in Indonesian
Cosmetics Association (HIKI); 2004.
9. Ruckmani K, Sankar V. Formulation and optimization of Zidovudine
niosomes. AAPS PharmSciTech 2010;11(3):1119-27.
10. Gupta A, Aggarwal G, Singla S, Arora R. Transfersomes: A novel
vesicular carrier for enhanced transdermal delivery of sertraline:
Development, characterization, and performance evaluation. Sci Pharm
2012;80(4):1061-80.
11. Jones DS, Lawlor MS, Woolfson AD. Examination of the
flow rheological and textural properties of polymer gels
composed of poly(methylvinylether-co-maleic anhydride) and
poly(vinylpyrrolidone): Rheological and mathematical interpretation
of textural parameters. J Pharm Sci 2002;91(9):2090-101.
12. Tan YT, Peh KK, Al-Hanbali O. Effect of carbopol and
polyvinylpyrrolidone on the mechanical, rheological, and release
properties of bioadhesive polyethylene glycol gels. AAPS
PharmSciTech 2000;1(3):E24.
13. Jones DS, Lawlor MS, Woolfson AD. Rheological and
mucoadhesive characterization of polymeric systems
composed of poly(methylvinylether-co-maleic anhydride) and
poly(vinylpyrrolidone), designed as platforms for topical drug delivery.
J Pharm Sci 2003;92(5):995-1007.
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How to Cite
Luthfiah, A., Sagita, E., & Iskandarsyah, I. (2017). PHYSICAL STABILITY TESTING OF P-SYNEPHRINE PREPARED AS TRANSFERSOME GEL. International Journal of Applied Pharmaceutics, 9, 124-126. https://doi.org/10.22159/ijap.2017.v9s1.70_77
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Original Article(s)