EVALUATING OF EFFERVESCENT TABLETS CONTAINING GRAPE SEED (VITIS VINIFERA L.) EXTRACT AS A NUTRACEUTICAL


Silvia Surini, Mutiah Rakhma Wisnu Wardani, Erny Sagita

Abstract


Objective: Grape is one of the most well-known fruits. People usually consume only the fruit and the skin; however, the seed is the part of the fruit
that contains important antioxidant rich polyphenol. However, grape seed and its extract have an unpleasant taste. Therefore, this study aimed to
formulate effervescent tablets containing grape seed extract (GSE) to overcome the unpleasant taste.
Methods: Effervescent tablets of GSE were formulated using three formulas, each with a different percentage of the effervescent mix. The tablets were
prepared using wet granulation method at 40% relative humidity (RH) (the ratio of the partial pressure of water vapor to the equilibrium vapor pressure of
water) and 25°C temperature. The effervescent granules and the tablets were evaluated for various characteristics in term of granules flowability, moisture
content, as well as tablets appearance, size and weight uniformity, hardness, friability, effervescence time, pH, and total phenol content. In addition, all three
formulations of the effervescent tablets and solutions were evaluated for appearance, taste, and flavor using the hedonic test that involved 30 panelists.
Results: The evaluation of the effervescent granules and tablets showed that they had good characteristics. The disintegration time of the three
formulations was within the acceptable range, between 3.67 minutes and 4.69 minutes. The pH of the effervescent solution was between 5.18 and
5.80. Based on the hedonic test, all the effervescent solutions had favorable appearance, taste, and flavor.
Conclusions: Clinical Streptococcus salivarius isolates from the dorsum of the tongue had greater potential for inhibiting Enterococcus faecalis growth
compared to the saliva isolates and control bacteria. Therefore, we can conclude that the effervescent tablets containing grape seed extract are
potential be used as a nutraceutical dosage form.


Keywords


Effervescent tablets, Nutraceutical, Grape seed

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About this article

Title

EVALUATING OF EFFERVESCENT TABLETS CONTAINING GRAPE SEED (VITIS VINIFERA L.) EXTRACT AS A NUTRACEUTICAL

Keywords

Effervescent tablets, Nutraceutical, Grape seed

DOI

10.22159/ijap.2017.v9s1.76_83

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 150-153

Online ISSN

0975-7058

Statistics

14 Views | 27 Downloads

Authors & Affiliations

Silvia Surini
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia
Indonesia

Mutiah Rakhma Wisnu Wardani
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
Indonesia

Erny Sagita
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
Indonesia


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