• SILVIA SURINI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia
  • DIAN NOVITASARI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia.
  • ARRY YANUAR Laboratory of Biomedical Computation, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia


Objective: Lansoprazole (LPZ) is a Biopharmaceutics Classification System Class II drug. It has low solubility and high permeability, so its rate of
dissolution is a rate-limiting step for drug absorption. This study aimed to improve the dissolution rate of LPZ by forming cocrystals, using nicotinamide
(NCT) as the conformer.
Methods: Cocrystals of LPZ were produced using the solvent evaporation and solvent-drop grinding methods with a molar ratio of 1:1 and 1:2.
The cocrystals were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanning
calorimetry (DSC). The solubility and dissolution of the LPZ cocrystals were examined in distilled water.
Results: FTIR was used to confirm the formation of hydrogen bonds between LPZ and NCT. DSC and XRD studies showed the formation of crystals
from cocrystals and a decrease of the melting point of the cocrystals. The dissolution study revealed that the cocrystals could increase the LPZ
dissolution rate by up to 8.4-fold compared with pure LPZ.
Conclusion: LPZ cocrystal formation with NCT was successful in increasing the dissolution rate of LPZ.

Keywords: Lansoprazole, Nicotinamide, Cocrystals, Dissolution rate


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How to Cite
SURINI, S., NOVITASARI, D., & YANUAR, A. (2020). DISSOLUTION ENHANCEMENT OF LANSOPRAZOLE USING COCRYSTALLIZATION. International Journal of Applied Pharmaceutics, 12(1), 202-206. https://doi.org/10.22159/ijap.2020.v12s1.FF046
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