FORMULATION AND EFFECTIVENESS OF A HAND SANITIZER GEL PRODUCED USING SALAM BARK EXTRACT

  • Silvia Surini Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,
  • Nurul Isti Amirtha Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,
  • Delly Chipta Lestari Microbiology Clinic, Faculty of Medicine, Universitas Indonesia, Cikini, Jakarta, 10320, Indonesia.

Abstract

Objective: The objectives of this study were to determine the minimum inhibitory concentration (MIC) of Salam bark extract against Staphylococcus
aureus, formulate and evaluate hand sanitizer gels containing Salam bark extract, and determine the effectiveness of the gels against bacteria on the
palms of the hands.
Methods: The gel base was optimized by preparing three formulations containing carbomer and triethanolamine at ratios of 0.25%:0.5%, 0.5%:1%,
and 0.5%:2%. The best gel formulation was mixed with Salam bark extract. The physical stability of gels containing 4.04% (formulation 1) and 7.77%
(formulation 2) Salam bark extract was measured at 4±2°C, 27±2°C, and 40±2°C for 12 weeks. The effectiveness of the gels was examined on the palms
of 30 respondents.
Results: The MIC of Salam bark extract was 3.12%. The best gel base contained carbomer and triethanolamine at a ratio of 1–4 and a pH of 5.50.
Formulations 1 and 2 gels had good stability for 12 weeks. Formulation 2 tended to decrease the number of bacteria (p=0.125) better than formulation
1 (p=1.000). In the hedonic study, formulation 2 was preferred to formulation 1.
Conclusion: Formulation 2 gel with 7.77% Salam bark extract was more effective than formulation 1 gel with 4.04% extract in decreasing the number of
bacteria on the palms.

Keywords: Antibacterial, Hand sanitizer, Minimum inhibitory concentration, Physical stability, Salam bark extract.

References

1. Putra A, Masri ME. Test the effect of antibacterial extract of ethanol
bark of salam stem [Syzigium polyanthum (Wight) Walp] against
Staphylococcus aureus and Escherichia coli in in vitro. J Kesehatan
Andalas I 2015;2015:500.
2. Benjamin DT. Introduction to Handsanitizers; 2010. Available from:
http://www.antimicrobialtest laboratories.com/information_about_
handsanitizers.html.
3. Centres for Disease Control and Prevention. Hand Sanitizer Ingredients;
2009. Available from: http://www.hand-sanitizer-dispenserreview.com/
hand-sanitizer-ingredients.htm. [Last accessed on 2016 Jan 20].
4. Radji M, Suryadi H, Ariyanti D. Test Antimicrobial Effectiveness of
Some Trademarks of Antiseptic Hand Cleansers. Depok: Faculty of
Pharmacy, Universitas Indonesia; 2007.
5. Hartatik P. Formulation of Antiseptic Gel Preparation of Essential
Lavender Flower Oil (Lavandula angustifolia Miller) with Carbopol
Base and Antibacterial Activity Against Staphylococcus aureus. Thesis.
Surakarta: Faculty of Pharmacy, Universitas Muhammadiyah; 2014.
6. Lateh MS. Formulation of Gel Sanitizer Handicraft Preparation of
Ethanol Acid Gelugur Fruit (Garcinia atroviridis Griff. Et Anders)
as Antibacterial to Staphylococcus aureus. Surakarta: Faculty of
Pharmacy, Universitas Muhammadiyah; 2015.
7. Department of Health, Republic of Indonesia. Formulary Cosmetics
Indonesia. Jakarta: Department of Health, Republic of Indonesia; 1985.
8. Wijayanto B, Kurniawan D, Sobri I. Formulation and Effectiveness of
Hand Antiseptic Gel of Galangal Essential Oil. Purwokerto: Universitas
Jendral Soedirman; 2013.
9. Zatz JL, Kushla GP. Gel. In: Lieberman HA, Rieger MM, Banker
GS, editors. Pharmacheutical Dosage Form: Disperse System. 2nd ed.
New York: Marcel Dekker; 1996. p. 399-421.
10. Tensiska C. Antioxidant activity of andaliman fruit extracts in several
food systems and the stability of their activity on temperature and pH
conditions. J Food Technol Indust 2003;14:3-4.
11. Hasyim NF, Baharudin GA. Gel formulation of starfruit juice. Majalah
Farmasi Farmakol 2011;15:5-9.
12. Heather AE, Adam CW. Transdermal and Topical Drug Delivery:
Principles and Practice. 1st ed. New Jersey: Wiley; 2012. p. 432
13. Todar K. The Normal Bacterial Flora of Humans. University of
Wisconsin: Department of Bacteriology; 2008. Available from: http//
www.textbookofbacteriology.net/index.html.
14. Harborne J. Phytochemical Method: A Guide to Modern Way to
Analyze Plants. 2nd ed. Bandung: ITB Journal Publisher; 2006.
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How to Cite
Surini, S., Amirtha, N. I., & Lestari, D. C. (2018). FORMULATION AND EFFECTIVENESS OF A HAND SANITIZER GEL PRODUCED USING SALAM BARK EXTRACT. International Journal of Applied Pharmaceutics, 10(1), 216-220. https://doi.org/10.22159/ijap.2018.v10s1.48
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