PREPARATION AND CHARACTERIZATION OF CHITOSAN SUCCINATE AS COATING POLYMER FOR ENTERIC-COATED TABLET

  • Silvia Surini Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,
  • Koko Prakoso Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,

Abstract

Objective: This present study was aimed to evaluate the potential of chitosan succinate as a coating polymer.
Methods: In this study, chemical modification of chitosan was performed by substituting a succinate group into chitosan’s amine group. This reaction
used a water-solvent method to obtain chitosan succinate. Chitosan succinate was characterized and used as a coating agent in enteric-coated tablet
dosage forms containing sodium diclofenac as the drug model at concentrations of 3% and 4% and combined it with hydroxypropyl methylcellulose
phthalate (HPMCP) in ratios of 3:1 and 2:1 (3%). The obtained tablets were evaluated based on their physical appearance, uniformity of weight and
size, thickness film, disintegration time for an hour in acid, and dissolution profile.
Results: Although the enteric-coated tablets with 3% and 4% chitosan succinate dissolved after 1 h in acid, they could not hold drug release in the
acid medium under 10%. The enteric-coated tablet combined with chitosan succinate and HPMCP (3:1 and 2:1) at 3% did not dissolve after 1 h in the
acid medium and could hold drug release up to 8.53% in acid.
Conclusion: A combination of chitosan succinate and HPMCP (3:1 and 2:1) at 3% has a better ability to hold drug release in acid medium and met the
requirement as a coating in enteric-coated tablet dosage forms.

Keywords: Enteric-coated tablet, Chitosan succinate, N-acylation chitosan, Sodium diclofenac.

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How to Cite
Surini, S., & Prakoso, K. (2018). PREPARATION AND CHARACTERIZATION OF CHITOSAN SUCCINATE AS COATING POLYMER FOR ENTERIC-COATED TABLET. International Journal of Applied Pharmaceutics, 10(1), 343-347. https://doi.org/10.22159/ijap.2018.v10s1.76
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