FORMULATION OF MULBERRY LEAF (MORUS ALBA L.) EXTRACT HYDROGEL BEADS USING CROSS-LINKED PECTIN


Silvia Surini, Defira Metha Diandra

Abstract


Objective: Nutraceutical products have now gained considerable interest to be consumed regularly. Since the active substances in nutraceutical
products are provided by nature, they are safe to consume. The development of a dosage form and the appearance of a modern nutraceutical product
can improve product quality. Therefore, this research aimed to formulate a nutraceutical product, mulberry leaf extract, into hydrogel beads that swell
in water and that can be administered orally.
Methods: Deoxynojirimycin, the active substance in mulberry leaf extract hydrogel beads, has the efficacy of an anti-diabetic agent. In this research,
there were four formulations: The variations 1:2 and 1:3 of the extract-to-polymer ratio and the variations 2.5% and 5% of the cross-linker
concentration.
Results: The results showed that hydrogel beads had a spherical form with an unsmooth surface and a brown color, and they were able to swell in
water. The best formula was Formula 1, with a 1:2 extract-to-polymer ratio and a 2.5% cross-linker concentration. Formula 1 produced an average
diameter of 3.6 mm, a swelling ability of 210.68%, and immediate swelling in water for 30 seconds.
Conclusions: Mulberry leaf extract hydrogel beads could be used as an interesting nutraceutical product.


Keywords


Beads, Mulberry leaf extract, Pectin, Zinc acetate.

| PDF |

References


Patil JS, Kamalapur MV, Marapur SC, Kadam DV. Ionotropic gelation

and polyelectrolyte complexation: The novel techniques to design

hydrogel particulate sustained, modulated drug delivery system - A

review. Dig J Nanomater Biostruct 2010;5(1):241-8.

Shukla Y, George J. Combinatorial strategies employing nutraceuticals

for cancer development. Ann N Y Acad Sci 2011;1229:162-75.

Nabavi SM, Daglia M, Braidy N, Nabavi SF. Natural products,

micronutrients, and nutraceuticals for the treatment of depression:

A short review. Nutr Neurosci 2017;20(3):180-94.

Mohammadi J, Naik PR. Evaluation of hypoglycemic effect of Morus

alba in an animal model. Indian J Pharmacol 2008;40(1):15-8.

Wilson RD, Islam MS. Effects of white mulberry (Morus alba) leaf

tea investigated in a Type 2 diabetes model of rats. Acta Pol Pharm

;72(1):153-60.

Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K,

et al. Food-grade mulberry powder enriched with 1-deoxynojirimycine

suppresses the elevation of postprandial blood glucose in human.

J Agric Food Chem 2007;55(14):5869-74.

Maulida D, Estiasih T. Hypoglycaemic effect of gadung tuber

(Dioscorea hispida) water soluble polysaccharide and alginate:

A review. J Pangan Agroindustri 2014;2(3):136-40.

Das S, Ng K, Ho PC. Formulation and optimization of zinc-pectinate

beads for the controlled delivery of resveratrol. AAPS Pharm Sci Tech

;11(2):729-42.

Maitra J, Shukla VK. Cross-linking in hydrogels - A review. Am J

Polym Sci 2014;4(2):25-31.




About this article

Title

FORMULATION OF MULBERRY LEAF (MORUS ALBA L.) EXTRACT HYDROGEL BEADS USING CROSS-LINKED PECTIN

Keywords

Beads, Mulberry leaf extract, Pectin, Zinc acetate.

DOI

10.22159/ijap.2017.v9s1.78_85

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 159-162

Online ISSN

0975-7058

Statistics

11 Views | 25 Downloads

Authors & Affiliations

Silvia Surini
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Defira Metha Diandra
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia
Indonesia


Refbacks

  • There are currently no refbacks.