CORRELATION OF SERUM OSTEOCALCIN LEVEL AND PERIODONTAL ATTACHMENT LOSS WITH OSTEOPOROSIS RISK STATUS IN POSTMENOPAUSAL WOMEN


Dimas Ilham Hutomo, Sri Lelyati C Masulili, Fatimah Maria Tadjoedin, Lindawati S Kusdhany

Abstract


Objective: To assess the relationship between serum osteocalcin and periodontal clinical attachment loss (CAL) in postmenopausal women in relation to their osteoporosis risk status.

Methods: A cross-sectional study was carried out on 71 postmenopausal women in Kenari District, Central Jakarta, Indonesia. The periodontal examination for all the subjects included a CAL measurement. The serum osteocalcin level was analyzed using ELISA.

Results: The correlation between the serum osteocalcin level in patients with CAL and the risk of osteoporosis was analyzed with the Spearman test. The normal group had 29 subjects (40.84%), the osteopenic group had 23 subjects (32.39%), and the osteoporotic group had 19 subjects (26.76%). There was a significant correlation between CAL and the osteoporosis high-risk status (p<0.05) and no significant correlation between the serum osteocalcin level and the osteoporosis status (p>0.05).

Conclusion: No correlation was found between CAL and the serum osteocalcin level (p>0.05).

Keywords


Osteoporosis, Osteocalcin, Clinical attachment loss, Postmenopausal women

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References


Bernabei R, Martone AM, Ortolani E, Landi F, Marzetti E. Screening, diagnosis and treatment of osteoporosis: A brief review. Clin Cases Miner Bone Metab 2014;11:201-7.

Esfahanian V, Shamami MS, Shamami MS. Relationship between osteoporosis and periodontal disease: Review of the literature. J Dent (Tehran) 2012;9:256-64.

Widjanarko AL, Wachjudi RG, Chaidir MR. Do we need to perform bilateral hip bone mineral density examination? Indones J Rheumatol 2016;8:6-9.

Bodduru R, Deshmukh K, Chintawa S, Nayyar S. Osteoporosis and periodontal disease: Association and mechanisms: An in-depth review. Int J Therap Appl 2016;32:11-9.

Haq MW, Tanwir F, Tabassum S, Nawaz M, Siddiqui MF. Association of periodontitis and systemic diseases. Int J Dent Oral Health 2015;1:1-7.

Guiglia R, Di Fede O, Lo Russo L, Sprini D, Rini GB, Campisi G. Osteoporosis, jawbones and periodontal disease. Med Oral Patol Oral Cir Bucal 2013;18:e93-9.

Pepelassi E, Nicopoulou-Karayianni K, Archontopoulou AD, Mitsea A, Kavadella A, Tsiklakis K, et al. The relationship between osteoporosis and periodontitis in women aged 45-70 years. Oral Dis 2012;18:353-9.

Marques MR, Silva MA, Barros SP. Periodontal disease and osteoporosis association and mechanisms: A review of the literature. Braz J Oral Sci 2003;2:137-40.

Dodd DZ, Rowe DJ. The relationship between postmenopausal osteoporosis and periodontal disease. J Dent Hyg 2013;87:336-44.

Zanatta LC, Boguszewski CL, Borba VZ, Kulak CA. Osteocalcin, energy and glucose metabolism. Arq Bras Endocrinol Metabol 2014;58:444-51.

Hienz SA, Paliwal S, Ivanovski S, Cells B. Mechanisms of bone resorption in periodontitis author mechanisms of bone resorption in periodontitis. J Immunol Res 2015;2015:1-10.

Ali MR, Zaidan TF, Gorial FI. Validity of osteocalcin and alkaline phosphatase biomarkers in postmenopausal women with low bone mineral density. J Chemist and Mater Res 2014;6:13-9.

Singh S, Kumar D, Lal AK. Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women. J Clin Diagn Res 2015;9:4-7.

Kusdhany LS, Rahardjo TB, Sutrisna B. The development of mandibular bone density index to detect mandibular osteoporosis of postmenopausal women. Int J Oral Heath 2005;2:21-5.

Khanna V, Gupta P, Khanna R, Khanna HC. Postmenopausal osteoporosis. JOJ Case Stud 2017;1:1-5.

Juluri R, Prashanth E, Gopalakrishnan D, Kathariya R, Devanoorkar A, Viswanathan V, et al. Association of postmenopausal osteoporosis and periodontal disease: A double-blind case-control study. J Int Oral Health 2015;7:119-23.

Bolarin DM, Ekpe EL, Saidu K, Eyam ES. A glance at biomarkers of bone metabolism. Pak J Nutr 2016;15:499-504.

Ram VS, Parthiban, Sudhakar U, Mithradas N, Prabhakar R. Bonebiomarkers in periodontal disease: A review article. J Clin Diagn Res 2015;9:ZE07-10.

Becerik S, Afacan B, Oztürk VÖ, Atmaca H, Emingil G. Gingival crevicular fluid calprotectin, osteocalcin and cross-linked N-terminal telopeptid levels in health and different periodontal diseases. Dis Markers 2011;31:343-52.

Masulili SL, Tadjoedin FM, Masulili C, Indrasari M, Kusdhany LS. Periodontal attachment loss and bone mineral density. J Int Dent Med Res 2016;9:233-6.

Bullon P, Goberna B, Guerrero JM, Segura JJ, Perez-Cano R, Martinez-Sahuquillo A. Serum, saliva, and gingival crevicular fluid osteocalcin: Their relation to periodontal status and bone mineral density in postmenopausal women. J Periodontol 2005;76:513-9.




About this article

Title

CORRELATION OF SERUM OSTEOCALCIN LEVEL AND PERIODONTAL ATTACHMENT LOSS WITH OSTEOPOROSIS RISK STATUS IN POSTMENOPAUSAL WOMEN

Keywords

Osteoporosis, Osteocalcin, Clinical attachment loss, Postmenopausal women

DOI

10.22159/ijap.2017.v9s2.22

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue 2 (Dec.), 2017 Page: 92-94

Online ISSN

0975-7058

Statistics

88 Views | 97 Downloads

Authors & Affiliations

Dimas Ilham Hutomo
Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Sri Lelyati C Masulili
Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Fatimah Maria Tadjoedin
Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Lindawati S Kusdhany
Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia


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