• RADITYA PRIHARNANTO Periodontology Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ROBERT LESSANG Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • SRI LELYATI C MASULILI Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • FATIMAH MARIA TADJOEDIN Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • HERLIS RAHDEWATI Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • PITU WULANDARI Department of Periodontology, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia, Indonesia.
  • ELZA IBRAHIM AUERKARI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.


Objective: Periodontitis is an infection that involved tooth-supporting tissues by dental plaque biofilm on the tooth surface and host immune response
as causal to as inflammation resolution. Prostaglandin E2 (PGE2) as an inflammatory mediator has been implicated in the pathogenesis of various
chronic inflammatory diseases, including periodontitis, and as a regulator of blood pressure. This study aims to compare the levels of prostaglandin
in the gingival crevicular fluid (GCF) of periodontitis patients with hypertension and non-hypertension.
Methods: A total sample of 62 patients was examined and consists of 44 patients (aged 50–90 years) who were hypertension group and 18 patients
(aged 30–49 years) who were non-hypertension groups as a control. Hypertension state was measured by blood pressure based on anamnesis
and using sphygmomanometer mercury. The clinical sample was collected from 62 gingival crevicular fluids [GCF] of periodontal disease subject.
Measurement of the clinical parameter of probing pocket depth [PD], and bleeding on probing [BOP ≥1] was included as a diagnostic requisition.
The PD and clinical attachment loss [CAL] was defined as present if the PD was ≥5 mm and CAL was ≥1 mm. Prostaglandin E2 level was estimated in
gingival crevicular fluid samples by using the enzyme-linked immunosorbent assay.
Results: The level of PGE2 was statistically significant difference in hypertension patient compare with non-hypertension (p<0.05). There was a
significant difference in PD, recession, and CAL (p<0.05).
Conclusion: Higher blood pressure might be related to the potential risk of inflammation and progression periodontal disease.

Keywords: Prostaglandin E2, Periodontitis, Hypertension, Inflammation


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