EFFECT OF HERBAL TOOTHPASTE CONTAINING NEEM LEAVES EXTRACT (AZADIRACHTA INDICA) AGAINST GINGIVITIS: A CLINICAL STUDY

  • AMELIA PRISCILLA SUGIARTA Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
  • ROBERT LESSANG Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
  • NATALINA . Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Abstract

Objective: Neem leaves are known to have antibacterial, anti-inflammatory, antifungal, antiseptic, antitumor, antihyperglycemic, antiulcer, and
antiviral effects. In addition, they can reduce the counts of plaque-forming bacteria in the oral cavity. This study aimed to evaluate the effect of an
herbal toothpaste containing neem leaves extract against gingivitis.
Methods: A total of 40 subjects were divided into two groups (n=20 each): Experimental and control. Those in the test group were instructed to brush
their teeth twice a day for 7 days with neem leaves extract toothpaste, whereas the control group subjects were asked to continue with the non-herbal
paste they used for tooth brushing. Plaque index (PI) and papillary bleeding index (PBI) were measured on day 0 and day 7.
Results: Significant reductions in PI and PBI were noted between the test and control groups.
Conclusion: The findings of this clinical study provide evidence that neem leaf extracts are effective in reducing gingivitis.

Keywords: Neem leaves extract, Gingivitis, Plaque index, Papillary bleeding index

References

1. Ministry of Health, Republic of Indonesia. Indonesia Health Profile.
Jakarta: Ministry of Health, Republic of Indonesia; 2011.
Fig. 1: Comparison diagram of plaque indeks score before and
after use of toothpaste in control and test group
Fig. 2: Comparison diagram of pbi score before and after use of
toothpaste in control and test group
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Sugiarta et al.
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2. John NM. Classification of disease and conditions affecting the
periodontium. In: Newman MG, Takei HH, Carranza FA, editors.
Clinical Periodontology. 10th ed. Philadelphia, PA: W.B. Saunders Co.;
2006. p. 100-4.
3. Allen DL, McFall WT, Hunter GC. Periodontics for Dental Hygienist.
2nd ed. Great Britain: Lea and Febiger; 1986. p. 60-86.
4. Grant DA, Stern IB, Everett FG. Orban’s Periodontics a Concept-
Theory and Practice. London: C.V Mosby Co.; 1972. p. 28-35.
5. Pratiwi R. Differences in the inhibitory power of Streptococcus mutans
from herbal toothpaste. Majalah Kedokt Gigi 2005;38:64-7.
6. Davies R, Scully C, Preston AJ. Dentifrices-an update. Med Oral Patol
Oral Cir Bucal 2010;15:e976-82.
7. Furgang D, Sreenivasan PK, Zhang YP, Fine DH, Cummins D. The
effects of a new therapeutic triclosan/copolymer/sodium-fluoride
dentifrice on oral bacteria, including odorigenic species. Compend
Contin Educ Dent 2003;24:14-9.
8. Tsyarini E, Rusmana D, Widya. Comparison of the Effectiveness of
Herbal Toothpaste and Nonherbal Toothpaste in Inhibiting the Growth
of Staphylococcus aureus, Streptococcus ?-hemoliticus and Candida
albicans in vitro. [In Indonesia]. [Thesis]. Faculty of Dentistry,
Universitas Maranatha; 2003. p. 1-27.
9. Girish K, Shankara SB. Neem-a green treasure. Electron J Biol
2008;4:102-11.
10. Botelho MA, dos Santos RA, Martins JG, Carvalho CO, Paz MC,
Azenha C, et al. Efficacy of a mouthrinse based on leaves of the neem
tree (Azadirachta indica) in the treatment of patients with chronic
gingivitis: A double blind, randomized, controlled trial. J Med Plant
Res 2008;2:341-6.
11. Masluhiya S. Pemanfaatan Daun Mimba (Azadirachta indica); 2011.
Available from: http://www.jamu.biologi.ub.ac.id/?page_id=397.
12. Saradhajyoti K, Subbarao B. Antibacterial potential of extract of the
leaves of Azadirachta indica Linn. Not Sci Biol 2011;3:65-9.
13. Carranza FA, Rapley JW. Clinical features of gingivitis. In: Carranza FA,
Newman MG, Takei HH, editors. Carranza’s Clinical Periodontology.
9th ed. Toronto: WB. Saunders Co.; 2002. p. 269-77.
14. Markou E, Eleana B, Lazaros T, Antonios K. The influence of sex
steroid hormones on gingiva of women. Open Dent J 2009;3:114-9.
15. Chatterjee A, Saluja M, Singh N, Kandwal A. To evaluate the
antigingivitis and antipalque effect of an Azadirachta indica (Neem)
mouthrinse on plaque induced gingivitis: A double-blind, randomized,
controlled trial. J Indian Soc Periodontol 2011;15:398-401.
16. Wolinsky LE, Mania S, Nachnani S, Ling S. The inhibiting effect of
aqueous Azadirachta indica (Neem) extract upon bacterial properties
influencing in vitro plaque formation. J Dent Res 1996;75:816-22.
17. Bhat PK, Badiyani BK, Sarkar S, Chengappa S, Bhaskar NN.
Effectiveness of antimicrobial solutions on Streptococcus mutans in
used toothbrushes. World J Dent 2012;3:6-10.
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How to Cite
SUGIARTA, A. P., LESSANG, R., & ., N. (2019). EFFECT OF HERBAL TOOTHPASTE CONTAINING NEEM LEAVES EXTRACT (AZADIRACHTA INDICA) AGAINST GINGIVITIS: A CLINICAL STUDY. International Journal of Applied Pharmaceutics, 11(1), 117-119. https://doi.org/10.22159/ijap.2019.v11s1.AR173
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