ERADICATION EFFECT OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA. ROXB.) EXTRACT ON THE EARLY PHASE OF CANDIDA ALBICANS BIOFILM


Ria Puspitawati, Rista Lewiyonah, Ranny Rahaningrum Herdiantoputri, Ferry P Gultom, Dewi F. Suniarti

Abstract


Objectives: To analyze the effect of Javanese turmeric extract on eradicating the initial phase of C. albicans biofilm formation.

Methods: A 100 µl of C. albicans suspension 10−4 was cultured on a 96 - well plate, incubated for 1.5 and 3 h at 37° C and then aspirated and washed by phosphate buffer saline before exposure to 100 µl of 5%, 10%, 15%, 20% 25%, 30%, and 35% Javanese turmeric extract for 24 h. The positive control was 100 µl of nystatin 100,000 IU.

Results: The eradication effect of 35% Javanese turmeric extract at the two stages of initial phase biofilm was comparable with those of nystatin. The viability of C. albicans exposed to the extract at an advanced stage of the early phase of biofilm formation tended to be higher than that at the early stage, but the difference was not significant.

Conclusion: The in vitro antifungal effect of Javanese turmeric extract against C. albicans could be effective in eradicating yeast in the early phase of biofilm formation.


Keywords


Candida albicans biofilm, Javanese turmeric extract, Curcuma xanthorrhiza Roxb, Viability

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About this article

Title

ERADICATION EFFECT OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA. ROXB.) EXTRACT ON THE EARLY PHASE OF CANDIDA ALBICANS BIOFILM

Keywords

Candida albicans biofilm, Javanese turmeric extract, Curcuma xanthorrhiza Roxb, Viability

DOI

10.22159/ijap.2017.v9s2.29

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue 2 (Dec.), 2017 Page: 117-120

Online ISSN

0975-7058

Statistics

82 Views | 81 Downloads

Authors & Affiliations

Ria Puspitawati
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Rista Lewiyonah
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Ranny Rahaningrum Herdiantoputri
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Ferry P Gultom
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Dewi F. Suniarti
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia


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