EFFECT OF JAVANESE TURMERIC ETHANOL EXTRACT ON THE ERADICATION OF CANDIDA ALBICANS BIOFILMS IN EARLY, INTERMEDIATE, AND MATURATION PHASES

  • BETA BELATRIX Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No. 4, Jakarta Pusat 10430, Indonesia.
  • RIA PUSPITAWATI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No. 4, Jakarta Pusat 10430, Indonesia.
  • ARIADNA ADISATTYA DJAIS Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No. 4, Jakarta Pusat 10430, Indonesia.

Abstract

Objectives: The aim of this research was to observe the effect of Javanese turmeric ethanol extract (JTEE) on the eradication of Candida albicans in
various phases of biofilm development.
Methods: C. albicans biofilms were exposed to JTEE at a concentration 1–45% for 1 h. Cell viability was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-
diphenyltetrazolium bromide assay, and the wavelength was read at 570 nm.
Results: The results showed that the 50% minimal biofilm eradication concentration was 30% in the early phase, 20% in the intermediate phase, and
25% in the maturation phase of the biofilm. The eradication percentage increased along with increasing JTEE concentration, but decreased with the
age of the biofilm.
Conclusion: We concluded that JTEE has the potential to eradicate C. albicans biofilms in various phases of development.

Keywords: Biofilm,, Candida albicans, Javanese turmeric ethanol extract

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BELATRIX, B., PUSPITAWATI, R., & DJAIS, A. A. (2019). EFFECT OF JAVANESE TURMERIC ETHANOL EXTRACT ON THE ERADICATION OF CANDIDA ALBICANS BIOFILMS IN EARLY, INTERMEDIATE, AND MATURATION PHASES. International Journal of Applied Pharmaceutics, 11(1), 1-4. https://doi.org/10.22159/ijap.2019.v11s1.148
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