THE POTENCY OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA ROXB.) ETHANOL EXTRACT TO ERADICATE WILD STRAIN CANDIDA ALBICANS BIOFILM

  • AYU DIAH LESTARI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No.4, Jakarta Pusat 10430, Indonesia
  • RIA PUSPITAWATI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No.4, Jakarta Pusat 10430, Indonesia.
  • ARIADNA ADISATTYA DJAIS Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya No.4, Jakarta Pusat 10430, Indonesia.

Abstract

Objective: The pathogenic yeast Candida albicans forms biofilm to increase its resistance toward antifungal agents. Javanese turmeric is an Indonesian
medicinal plant reported to have antifungal effects due to the active component, xanthorrhizol. The objective of this study was to measure the in vitro
potential of Javanese turmeric ethanol extract to eradicate C. albicans biofilm.
Methods: C. albicans was exposed to Javanese turmeric ethanol extract for 1 h during biofilm formation phases. MTT assay was used to test the
percentage of biofilm eradication.
Results: The minimum inhibitory concentration and minimum fungicidal concentration of Javanese turmeric ethanol extract against planktonic
C. albicans were 15%. The minimum biofilm eradication concentration (MBEC50) was 25% in the early phase and 15% in the intermediate and
maturation phases.
Conclusions: Javanese turmeric ethanol extract is effective at eradicating clinical isolate of C. albicans biofilm.

Keywords: biofilm, Candida albicans clinical isolate, Javanese turmeric ethanol extract, MTT assay, Percentage of eradication
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LESTARI, A. D., PUSPITAWATI, R., & DJAIS, A. A. (2019). THE POTENCY OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA ROXB.) ETHANOL EXTRACT TO ERADICATE WILD STRAIN CANDIDA ALBICANS BIOFILM. International Journal of Applied Pharmaceutics, 11(1), 5-9. https://doi.org/10.22159/ijap.2019.v11s1.150
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