STRATEGY TO MASK THE BITTER TASTE OF MOMORDICA CHARANTIA EXTRACT USING ALGINATEâ€“GELATIN BEADS
Objective: This study is aimed to develop a strategy to mask the bitter taste of Momordica charantia Linn. extract using alginateâ€“gelatin beads.
Methods: Beads of bitter melon fruit extract (M. charantia Linn) were prepared using an ionic gelation method in which cross-linking occurs between
sodium alginate and calcium chloride that serves to mask the bitter taste. Beads were prepared using sodium alginate (1.5% w/v) with various
concentrations of bitter melon fruit extract (1:2, 1:1, and 1:0.5), gelatin (2% w/v), and CaCl2 3%. The obtained beads were then characterized both
physically and functionally, and their morphology, process efficiency, particle distribution, swelling index, and water content were recorded.
Results: Formula 1 beads, with a 1:2 ratio of extract: alginate, displayed a near-round shape with a diameter of 600â€“1 200 Î¼m, a swelling index of
113.21%, and a moisture content of 15.34%. In addition, these beads were able to significantly cover the bitter taste (p<0.05).
Conclusion: Formula 1 beads with a 1:2 ratio of extract: alginate can effectively mask the bitter taste of M. charantia Linn.
properties of Momordica charantia L. Polysaccharide in alloxaninduced
diabetic mice. Int J Biol Macromol 2015;81:538-43.
2. Semiz A, Sen A. Antioxidant and chemoprotective properties of
Momordica charantia L (bitter melon) fruit extract. Afr J Biotechnol
3. Puri M, Kaur I, Kanwar RK, Gupta RC, Chauhan A, Kanwar JR.
Ribosome inactivating proteins (RIPs) from Momordica charantia for
anti viral therapy. Curr Mol Med 2009;9:1080-94.
4. Tan H, Gan C. Polysaccharide with antioxidant, Î±-amylase inhibitory
and ACE inhibitory activities from Momordica charantia. Int J Biol
5. Zhang F, Lin L, Xie J. A mini-review of chemical and biological
properties of polysaccharides from Momordica charantia. Int J Biol
6. Donya AB. The Effects of Various Processing Methods on the
Momordicosides K and L Contents, and the Sensory Characteristics
of Bitter Melon Vegetable (Momordica charantia L.). United States:
University of Arkansas; 2007.
7. Gupta M, Sharma S, Gautam AK, Bhadauria R. Momordica charantia
Linn. (Karela): Natureâ€™s silent healer. Int J Pharm Sci Rev Res
8. Limtrakul P, Pitchakarn P, Suzuki S, Kuguacin J. A triterpenoid
from Momordica charantia Linn: A comprehensive review of
anticarcinogenic properties. Open Sci 2013;13:276-96.
9. Devi NKD, Chandana M, Sindhura A, Ratnavali G, Kavitha R.
Comparative evaluation of alginate beads prepared by ionotropic
gelation technique. Pharmacopore 2010;3:196-213.
10. TÃ¸nnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev
Ind Pharm 2002;28:621-30.
11. Dong Z, Wang Q, Du Y. Alginate/gelatin blend films and their
properties for drug controlled release. J Memb Sci 2006;280:
12. Saarai A, Kasparkova V, Sedlacek T, Saha P. On the development and
characterisation of crosslinked sodium alginate/gelatine hydrogels.
J Mech Behav Biomed Mater 2013;18:152-66.
13. Kumar SR, Ashish J, Satish N. Momordica charantia Linn.: A mini
review. Int J Manag Bus Res 2011;2:579-87.
14. Harmita. Textbook of Physicochemical Analysis. Depok: Department
of Pharmacy, Faculty of Mathematics and Natural Sciences Universitas
15. Namasivayam SK, Robin AT. Preparation, optimization and
characterization of biocompatible nanoalbumin-ofloxacin (BSANPâ€‘OF)
conjugate and evaluation of control release, anti bacterial activity
against clinical isolate of Pseudomonas aeruginosa. Asian J Pharm Clin
16. Nagavarma BV, Hemant KS, Ayaz A, Vasudha LS, Shivakumar HG.
Different techniques for preparation of polymeric nanoparticles - A
review. Asian J Pharm Clin Res 2012;5:16-23.
17. Farshid A, Lakshmi CS. Formulation of nanoparticles of antti-migraine
drugs triptans by coacervation method. Asian J Pharm Clin Res