• NURINDAH SALOKA TRISNANINGRUM Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • HENDRI ASTUTY Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.


Objective: This study aimed to ascertain the effectiveness of combination treatment with propolis and artemisinin-based combination therapy (ACT)
in avoiding further resistance to ACT.
Methods: A total of 35 mice were injected with Plasmodium berghei and divided into six equal groups: No treatment (negative control), ACT alone
(positive control), 75-mg propolis/kg body weight (BW), 150-mg propolis/kg BW, ACT with 75-mg propolis/kg BW, and ACT with 150-mg propolis/
kg BW. After 7 days of therapy, parasite density was calculated using a thin blood smear.
Results: Parasite density significantly declined after combination treatment with ACT and 150-mg propolis/kg BW.
Conclusion: Therapy with propolis alone showed no inhibitory effect on parasites, although its 150-mg/kg-BW dose was effective as an ACT adjuvant
malaria therapy in mice.

Keywords: Propolis, Malaria, Artemisinin-based combination therapy, Plasmodium berghei


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How to Cite
TRISNANINGRUM, N. S., & ASTUTY, H. (2019). EFFECTIVENESS OF PROPOLIS WITH ARTEMISININ COMBINATION THERAPY IN TREATING MICE INFECTED WITH PLASMODIUM BERGHEI. International Journal of Applied Pharmaceutics, 11(1), 262-264. https://doi.org/10.22159/ijap.2019.v11s1.012
Original Article(s)