SELECTED EXCIPIENTS IN ORAL SOLID DOSAGE FORM WITH DRY EXTRACT OF PYROLA ROTUNDIFOLIA L.
DOI:
https://doi.org/10.22159/ijap.2019v11i6.35282Keywords:
Pyrola rotundifolia L, Round-leaved wintergreen, Dry extract, Tablets, Mathematical planning of the experimentAbstract
Objective: The aim of the present study was to select excipients in an oral solid dosage form with a dry extract of round-leaved wintergreen (Pyrola rotundifolia L.) by using asymmetric, rotatable composite plan of the second-order (uniform plan No. 17).
Methods: The tablets were prepared by using a direct compression method. The most important pharmaceutical factors selected were considered in more details at developing the optimal composition and technology of the studied tablets of the round-leaved wintergreen extract. Each one was studied at five levels using asymmetric, rotatable composite plan of the second order.
Results: Increasing amounts of PROSOLV® EASYtab SP and croscarmellose sodium in the powder mass, its flowability decreases, and increasing amounts of Tablettose® 80 improves flowability. Increasing the amount of Tablettose® 80 in the tablets composition leads to improved uniformity. The strength of the tablets increased with increasing amounts of Neusilin® US 2 at different combinations of levels of the other three factors. When studying the effect of the amounts of croscarmellose sodium on the disintegration of tablets, it was found that the best disintegration values were obtained in the study of croscarmellose sodium at the upper level.
Conclusion: Oral solid dosage form with dry extract of round-leaved wintergreen was successfully prepared by the direct compression method. The optimal composition of tablets was determined by the regression analysis.
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Darzuli N, Vronska L, Groshovyi T, Beley N. Development of methods of standardization of medicinal plants–Pyrola rotundifolia leaf. Pharma Innov J 2017;6:17-21.
Darzuli N, Denys A, Hroshovyi T. Marketing research of the market of drugs and dietary supplements used for the treatment of inflammatory diseases of the urinary system. Pharm Rev 2017;4:50-6.
Slobodianiuk L, Budniak L, Marchyshyn S, Basaraba R. Determination of amino acids and sugars content in Antennaria dioica gaertn. Int J Appl Pharm 2019;11:39-43.
Stoiko L, Kurylo K. Development of optimal technology of alcohol extract Centaurium erythraea rafn herb. Arch Balk Med Union 2018;53:523-8.
Rożycki C, Synoradzki L. Teaching the experimental design. Lecture and exercises. Przemyst Chemiczny 2003;8-9:1342-4.
Patwari MAU, Nurul Amin AKM, Faris WF. Prediction of tangential cutting force in end milling of medium carbon steel by coupling design of experiment and response surface methodology. J Mech Eng 2009;40:95–103.
Patel V, Bisoniya TS. Experimental investigation of the effect of machining parameters on surface roughness in roller burnishing process. Int J Technol Res Engineer 2015;9:2201–4.
Bhagwat Durgacharan A, D’Souza John I. Development of solid self micro emulsifying drug delivery system with Neusilin US2 for enhanced dissolution rate of telmisartan. Int J Drug Dev Res 2012;4:398-407.
Dias RJ, Mali KK, Ghorpade VS, Havaldar VD, Mohite VR. Formulation and evaluation of carbamazepine liquisolid compacts using novel carriers. Ind J Pharm Edu Res 2017;51:S69-S78.
Hentzschel CM, Sakmann A, Leopold CS. Suitability of various excipients as carrier and coating materials for liquisolid compacts. Drug Dev Ind Pharm 2011;37:1200–7.
Aljaberi A, Ardakani A, Khdair A, Abdel-Rahim SA, Meqdadi E, Ayyash M, et al. Tableting functionality evaluation of prosolv easytab in comparison to physical mixtures of its individual components. J Drug Del Sci Tech 2013;23:499–504.
Prosolv EASYtab SP. Product overview. JRS Pharma. Available from: https://www.jrspharma.com/pharma_en/products-services/excipients/hfe/prosolv-easytab-sp.php. [Last accessed on 01 Aug 2019].
Croscarmellose Sodium. Product overview. Available from: https://www.roquette.com/pharma-and-nutraceuticals-croscarmellose-sodium. [Last accessed on 01 Aug 2019]
Tablettose 80. Product overview. Available from: https://www.meggle-pharma.com/en/lactose/7-tablettose80.html. [Last accessed on 01 Aug 2019]
Nelson D, Rebecca W, Wymbs K. Effect of magnesium stearate on tablet properties. Available from: https://pdfs.semanticscholar.org/ e009/
cd80edbba78a1b9d8643798efb715fa265.pdf. [Last accessed on 01 Aug 2019]
Jilika S, Monika T, Ajay KS, Amit RS. Study of microcrystalline cellulose as a substitute of magnesium stearate towards the functionality of lubricant in aspirin formulation. Int J Dev Res 2017;7:15879-84.
Marczynski Z, Zgoda MM, Bodek KH. Extract from Zingiber officinale rosc. in solid oral form of a drug. Herba Pol 2010;56:35-48.
Jaya S, Amala V. Formulation and in vitro evaluation of oral disintegrating tablets of amlodipine besylate. Int J Appl Pharm 2019;11:49-54.
Derzhavna Farmakopeya Ukrayini: v 3 t. Kharkiv: Derzhavne pidpriemstvo. Ukrayinskiy naukoviy farmakopeyniy tsentr yakosti likarskih zasobiv. State Pharmacopoeia Ukraine 2015;2:1121-5.
Barchuk OZ, Groshovyi TA, Zaliska OM, Shalata VJа. Study of the influence of excipients on pharmaco-technological properties of tablets based on the extract of bilberry leaves, extract of goat’s rue herbs and taurine obtained by direct compression method. Pharm Rev 2018;1:47-56.
Maraie NK, Salman ZD, Yousif NZ. Design and characterization of or slippery buoyant tablets for ranitidine hydrochloride. Asian J Pharm Clin Res 2018;11:143-9.
Patel A, Patel D, Banker K. Effect evaluation of roller burnishing process on surface roughness of 6061 T6 A l alloy using response surface methodology. Int J Sci Res Dev 2014;8:142–5.
Suresh PVS, Venkateswara Rao P, Deshmukh SG. A genetic algorithmic approach for optimization of surface roughness prediction model. Int J Machine Tools Manuf 2002;42:675–80.
Hroshovyi TA, Martsenyuk VP, Kucherenko LI, Vronska LV, Huryeyeva SM. Matematychne planuvannya eksperymentu v farmatsiyi [Mathematical planning of experiment in pharmacy]. Ternopil, Ukrainian: Ternopil State Medical University; 2008. p. 304-9.
Marczyński Z, Kowalczykiewicz K, Bodek KH. Selected excipients and surfactants in oral solid dosage form with extract of Phaseoli pericarpium (Phaseolus vulgaris L.). Herba Pol 2015;61:78-92.
Hiremath SP, Makanapur C. Formulation and evaluation of orodispersible tablets of a model anti-hypertensive drug. Int J Pharm Pharm 2017;9:34-8.
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