ANTIBACTERIAL ACTIVITY OF CELERY LEAVES (APIUM GRAVEOLENS L.) FORMULATED IN TOOTHPASTE AGAINST STREPTOCOCCUS MUTANS

  • ERZA GENATRIKA Department of Pharmaceutics and Technology, Pharmacy Faculty, Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
  • FITA SATRIANI Department of Pharmaceutics and Technology, Pharmacy Faculty, Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
  • INDRI HAPSARI Department of Pharmaceutics and Technology, Pharmacy Faculty, Universitas Muhammadiyah Purwokerto, Central Java, Indonesia

Abstract

Objective: The objective of this research was to determine the antibacterial activity of the toothpaste from an extract of celery leaves on Streptococcus
mutans.
Methods: The toothpaste was formulated with various concentrations of celery leaves, F1 with concentration of extract (6.25%), F2 (12.5%), and
F3 (25%). Each formula was tested the physical characteristics and antibacterial activity toward S. mutans. The antibacterial activity was determined
by the agar well diffusion method using brain heart infusion agar plates. Furthermore, the antibacterial activities were assessed by the presence or
absence of inhibition zones after the plates were incubated at 37°C for 24 h.
Results: The results from this test illustrate that all toothpastes under study at various concentrations of celery leaves extract exhibited antibacterial
activity. Maximum inhibition zone in antibacterial activity test was shown by F2 (12.5%). Therefore, we can use these toothpastes as natural
antibacterial on prevention of dental caries caused S. mutans.
Conclusion: The toothpaste from an extract of celery leaves showed significant antibacterial activity against S. mutans.

Keywords: Streptococcus mutans, Celery leaves, Toothpaste, Apium graveolens, Inhibition zone

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GENATRIKA, E., SATRIANI, F., & HAPSARI, I. (2019). ANTIBACTERIAL ACTIVITY OF CELERY LEAVES (APIUM GRAVEOLENS L.) FORMULATED IN TOOTHPASTE AGAINST STREPTOCOCCUS MUTANS. International Journal of Applied Pharmaceutics, 11(5), 14-16. https://doi.org/10.22159/ijap.2019.v11s5.T0028
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