ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-1 −1607 1G/2G POLYMORPHISM AND CHRONIC PERIODONTITIS IN INDONESIAN POPULATION

  • RAHMATUL HAYATI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
  • ANTONIUS WINOTO SUHARTONO Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • SRI LELYATI MASULILI Department of Periodontology Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • CHRISTOPHER TALBOT Department of Genetics, University of Leicester, Leicester, UK.
  • ELZA IBRAHIM AUERKARI Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Abstract

Objective: This study aimed to identify the distribution of matrix metalloproteinase (MMP)-1 −1607 1G/2G alleles and genotypes in subjects with
chronic periodontitis and healthy subjects in a sample of Indonesian population and assess the possible association of this polymorphism with
susceptibility to chronic periodontitis.
Methods: Genomic DNA samples were obtained from 200 Indonesian males aged 33–78 years old, comprising 100 chronic periodontitis patients
and 100 healthy controls. DNA fragments were amplified by a polymerase chain reaction and analyzed by restriction fragment length polymorphism.
Results were analyzed by Chi-square test.
Results: The frequency of the 2G allele was high both in subjects with periodontitis (87%) and in controls (91%). Analysis of MMP-1 genotype
(−1607 1G/2G) showed no significant difference between the chronic periodontitis and healthy groups (p>0.05).
Conclusion: The result found no association between MMP-1 −1607 1G/2G polymorphism and susceptibility to chronic periodontitis in Indonesian
subjects.

Keywords: Periodontitis, Matrix metalloproteinases-1, Genetic polymorphism, Indonesia

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HAYATI, R., SUHARTONO, A. W., MASULILI, S. L., TALBOT, C., & AUERKARI, E. I. (2020). ASSOCIATION BETWEEN MATRIX METALLOPROTEINASE-1 −1607 1G/2G POLYMORPHISM AND CHRONIC PERIODONTITIS IN INDONESIAN POPULATION. International Journal of Applied Pharmaceutics, 12(1), 15-17. https://doi.org/10.22159/ijap.2020.v12s1.ARL026
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