UFASOMES: UNSATURATED FATTY ACID BASED VESICULAR DRUG DELIVERY SYSTEM

  • sreeja c nair ASST. PROFESSOR, DEPARTMENT OF PHARMACEUTICS, AMRITA SCHOOL OF PHARMACY,AMRITA VISHWAVIDYAPEETHAM UNIVERSITY, AIMS- PONEKKARA P.O, KOCHI, KERALA, INDIA.
  • arundhasree
  • rajalakshmi r
  • aiswarya r
  • abhirami rajendra kumar
  • sreelakshmi s kumar

Abstract

Various novel drug delivery system has been developed encompassing several administration routes to deliver drugs at a rate decided as per the need of the body during the course of treatment and to achieve targeted therapy, also decreases undesirable side effects. Different types of vesicular drug delivery systems were developed such as liposomes, niosomes, ufasomes etc. Ufasomes are unsaturated fatty acid vesicles which is a suspension of closed lipid bilayer formed from fatty acid and their ionized species having limited narrow pH ranging from 7-9. Composition of fatty acid molecules is such that the hydrocarbon tails are pointed towards the inner core of the membrane and the carboxyl group are in touch with water. Stable ufasomes preparation mainly relies on appropriate choice of fatty acid, cholesterol quantity, range of pH, buffer and lipoxygenase amount. Recent innovation provides very efficient features such as stability considerations, dynamic features and microscopic features of ufasomes. The article furthermore provide the difference between ufasomes with liposomes.

Keywords: vesicular drug delivery system, unsaturated fatty acid vesicles, lipid peroxidation, birefringence, ufasomes, liposomes

Author Biography

sreeja c nair, ASST. PROFESSOR, DEPARTMENT OF PHARMACEUTICS, AMRITA SCHOOL OF PHARMACY,AMRITA VISHWAVIDYAPEETHAM UNIVERSITY, AIMS- PONEKKARA P.O, KOCHI, KERALA, INDIA.

DEPARTMENT OF PHARMACEUTICS

References

1. Dhanasekaran S, Chopra S. Getting a Handle on Smart Drug Delivery Systems- A Comprehensive View of Therapeutic Targeting Strategies. In: Ali DS, ed. Smart Drug Delivery System. Marmara University, Turkey: IntechOpen 2016; 32- 62.
2. Kamboj S, Saini V, Magon N, Suman Bala, Jhawat V. Vesicular drug delivery systems: A novel approach for drug targeting. Int J Drug Delivery 2013; 5:121-130.
3. Mujoriya R, Bodla RB, Dhamande K, Singh D, Patle L. Niosomal Drug delivery System: The Magic Bullet. J Appl Pharm Sci 2011; 09(1): 2231-3354.
4. Bangham AD, Standish MM, Watkins JG. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965; 13(1): 238-252.
5. Goldberg E.P.Eds., In; Targeted Drugs, 2nd edition, Wiley, New york 1983; 312.
6. Poste G., Krisch R., Koestler T. Liposome Technology. Vol. 3, CRC Press Inc, Banco Raton, F1 1983; 29
7. Nair AJ, Raju J, Arya GK, Nair SC. Bicosome: A versatile technology in biomedicine and dermopharmacy. Int J Res Pharm Sci 2018; 10(1): 186-195.
8. Pandita A, Sharma P. Pharmacosomes: An Emerging Novel Vesicular Drug Delivery System for Poorly Soluble Synthetic and Herbal Drugs. ISRN Pharm 2013; 1-10.
9. Biju SS, Talegaonkar S, Mishra PR, Khar RK. Vesicular system an overview. Indian J Pharm Sci 2006; 68:141-53.
10. Buchiraju R, Nama S, Sakala B, Chandu RB, Kommu A, Chebrolu JKB, Yedulapurapu N. Vesicular Drug Delivery System - An Over View. Res J Pharm, Biol Chem Sci 2013; 4(3): 462- 474.
11. Kumar D, Sharma D, Singh G, Singh M, Rathore MS. Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery. ISRN Pharm 2012; 1- 14.
12. Jain S, Jain V, Mahajan SC. Lipid Based Vesicular Drug Delivery Systems. Adv Pharm 2014; 1-12.
13. Vyas SP, Khar RK. Targeted and controlled drug delivery. CBS publisher: New Delhi; 2002.
14. Ashara KC, Pauni JS, Soniwala MM, Chavda JR, Nathawani SV, Mori NM, Mendapara VP. Vesicular Drug Delivery System: A Novel Approach. Mintage J Pharm Med Sci 2014; 3: 1-14.
15. Vijayakumar MR, Sathalia AH, Arun K. Formulation and evaluation of diclofenac potassium ethosomes. Int J Res Pharm Sci 2010; 2(4):82-86.
16. Rajan R, Jose S, Mukund VPB, Vasudevan DT. Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation, J Adv Pharm Technol Res 2011; 2(3): 138–143.
17. S. Lankalapalli and M. Damuluri. Sphingosomes: application in targeted drug delivery. Res J Pharm, Biol Chem Sci 2012; 2: 507–516.
18. Zishan M, Kushwaha P, Singh K, Amir M, Ansari VA, Sirbaiya AK, Singh SP.An Overview Of: Vesicular Drug Delivery System. World J Pharm Pharm Sci 2017; 6(5): 546-560.
19. Semalty A, Semalty M, Singh D, Rawat MSM. Development and physicochemical evaluation of pharmacosomes of diclofenac. Acta Pharm 2009; 59:335-344.
20. Shefrin S, Sreelaxmi CS, Vijayan V, Nair SC. Enzymosomes: A rising effectual tool for targeted drug delivery system. Int J Appl Pharm 2017; 9:1-9.
21. Sutariya V, Patel P. Aquasomes: a novel carrier for drug delivery. Int J Pharm Sci Res 2012; 3(3):688-694.
22. Tangri P, Khurana S. Niosomes: formulation and evaluation. International Journal of BioPharmaceutics 2011; 2(1): 47-53.
23. Arora D, Khurana B, Kumar MS, Vyas SP. Oral immunization against hepatitis B virus using mannosylated bilosomes. International Journal of Recent Advances in Pharmaceutical Research 2011; 1:45- 51.
24. Morigaki K, Walde P. Fatty acid vesicles. Curr Opin Colloid Interface Sci 2007; 12:75-80.
25. Gebicki JM, Hicks M. Ufasomes are stable particles surrounded by unsaturated fatty acid membranes. Nature 1973; 243: 232-4.
26. Hicks M, Gebicki JM. Preparation and properties of vesicles enclosed by fatty acid membranes. Chem. Phys. Lipids 1976; 16: 142-60.
27. Hargreaves WR, Deamer DW. Liposomes from ionic, single-chain amphiphiles.
Biochemistry 1978; 17: 3759-68.
28. Nair AJ, K Aswathi, George A, PP Athira, Nair SC. Ufasome: A potential phospholipid carrier as a novel pharmaceutical formulation. Int Res J Pharm 2014; 5(4):250-253.
29. Namani T, Walde P. From decanoate micelles to decanoic acid/ dodecylbenzenesulfonate vesicles. Langmuir 2005; 21:6210-6219.
30. Caschera F, Stano P, Luisi PL. Reactivity and fusion between cationic vesicles and fatty acid anionic vesicles. J Colloid Interface Sci 2010; 345:561-575.
31. Fukuda H, Goto A, Yoshioka H, Goto R, Morigaki K, Walde P. Electron spin resonance study of the pH-induced transformation of micelles to vesicles in an aqueous oleic acid/oleate system. Langmuir 2001; 17: 4223-31.
32. Hicks M, Gebicki JM. Inhibition of peroxidation in linoleic acid membranes by nitroxide radicals, butylated hydroxytoluene, and ?-tocopherol. Arch Biochem Biophys 1981; 210:56-63.
33. McLean LR, Hagaman KA. Effect of lipid physical state on the rate of peroxidation of liposomes. Free Radical Biol Med 1992; 12:113-9.
34. Aruoma OI, Halliwell B, Laughton MJ, Quinlan GL, Gutteridge JM. The mechanism of initiation of lipid peroxidation: Evidence against a requirement for an iron (II)-iron (III) complex. Biochem J 1989; 258:617-20.
35. Scarpa M, Rigo A, Maiorino M, Ursini F, Gregolin C. Formation of ?-tocopherol radical and recycling of ?-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes: An electron paramagnetic resonance study. Biochim Biophys Acta 1984; 28: 215-9.
36. Gutteridge JM, Quinlan GJ, Clark I, Halliwell B. Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. Biochim Biophys Acta 1985; 835: 441-7.
37. Barenholz Y. Liposome application: Problems and prospects. Curr Opin Colloid Interface Sci 2001; 6:66-77.
38. Namani T, Ishikawa T, Morigaki K, Walde P. Vesicles from docosahexaenoic acid. Colloids Surf B Biointerfaces 2007; 54: 118-23.
39. Borne J, Nylander T, Khan A. Vesicle formation and other structures in aqueous dispersions of monoolein and sodium oleate. J Colloid Interface Sci 2003; 257: 310-20.
40. Roy S, Dey J. Self-organization and microstructures of sodium 11- acrylamidoundecanoate in water. Langmuir, 2003; 19:9625-9.
41. Nayak RR, Roy S, Dey J. Characterization of polymeric vesicles of poly (sodium 11-acrylamidoundecanoate) in water. Colloid Polym Sci 2006; 285: 219-24.
42. Hao J, Liu W, Xu G, Zheng L. Vesicles from salt-free cationic and anionic surfactant solutions. Langmuir 2003; 19: 10635-40.
43. Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles. Biophys J 2004; 87: 988-.
44. Patel DM, Jani RH, Patel CN. Ufasomes: A vesicular drug delivery. Syst Rev Pharm 2011; 2(2): 72-78.
45. Hicks M, Gebicki JM. Microscopic studies of fatty acid vesicles. Chem Phys Lipids 1976; 20:243-52.
46. Vemuri S, Rhodes CT. Preparation and characterization of liposomes as therapeutic delivery systems: A review. Pharm Acta Helv 1995; 70: 95-111.
47. Schreier H, Bouwstra J. Liposomes and niosomes as topical drug carriers: Dermal and transdermal drug delivery. J Controlled Release 1994; 30: 1-15.
48. Vandenbergh BA, Salomonsdevries I, Bouwstra JA. Interactions between liposomes and human stratum corneum studied by freeze-substitution electron microscopy. Int J Pharm 1998; 167:57-67.
49. Robenek H, Severs NJ. Recent advances in freeze-fracture electron microscopy: The replica immunolabeling technique. Biol. Proced Online 2008; 10:9-19.
50. Guiot P, Baudhuin P, Gotfredsen C. Morphological characterization of liposome suspensions by stereological analysis of freeze-fracture replicas from spray-frozen samples. J Microsc 1980; 120: 159-74.
51. Mishima K, Satoh K, Ogihara T. Optical birefringence of phosphatidylcholine liposomes in gel phases. Biochim Biophys Acta 1987; 898: 231-238.
52. Vanhoogdalem EJ, Deboer AG, Bireimer DD. Intestinal drug absorption enhancement: An overview. Pharmacol Ther 1989; 44:407-443.
53. Fukui H, Murakami M, Takada K, Muranishi S. Combinative promotion effect of Azone and fusogenic fatty acid on the large intestinal absorption in rat. Int J Pharm 1986; 31: 239-46.
54. Patel HM, Ryman BE. Oral administration of insulin by encapsulation within liposomes. FEBS Lett 1976; 62:60-3.
55. Patel HM, Stevenson RW, Parsons JA, Ryman BE. Use of liposomes to aid intestinal absorption of entrapped insulin in normal and diabetic dogs. Biochem Biophys Acta 1982; 716:188-93.
56. Takeuchi H, Yamamoto H, Hino T, Kawashima Y. Enteral absorption of insulin in rats from mucoadhesive chitosan coated liposomes. Pharm Res 1996;13: 896-901.
57. Bolla, PK, Meraz, CA, Rodriguez VA, Deaguero I, Singh M, Yellepeddi VK, Renukuntla J. Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies. Molecules 2019; 24(17): 3139.
58. Verma S, Bhardwaj A, Vij M, Bajpai P, Goutam N, Kumar L. Oleic acid vesicles: a new approach for topical delivery of antifungal agent. Artif Cells, Nanomed, Biotechnol 2014; 42:95–101.
59. Zakir F, Vaidya B, Goyal AK, Malik B, Vyas SP. Development and characterization of oleic acid vesicles for the topical delivery of fluconazole. Drug Delivery 2010; 17:238–248.
60. Kumar P, Singh S, Handa, V, Kathuria, H. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery. Medicines 2018; 5(3), 103.
61. Salama AH, Aburahma MH. Ufasomes nano-vesicles-based lyophilized platforms for intranasal delivery of cinnarizine: preparation, optimization,ex-vivohistopathological safety assessment and mucosal confocal imaging. Pharm Dev Technol 2015; 1–10.
62. Sharma A, Arora S. Dermal delivery of glucosamine sulphate: formulation, characterization and performance evaluation. World J Pharm Pharm Sci 2013; 2: 6448–6462.
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nair, sreeja c, arundhasree, r, rajalakshmi, aiswarya r, abhirami rajendra kumar, & sreelakshmi s kumar. (2021). UFASOMES: UNSATURATED FATTY ACID BASED VESICULAR DRUG DELIVERY SYSTEM. International Journal of Applied Pharmaceutics, 13(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/39526
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