NOVASOME: A PIONEERING ADVANCEMENTIN VESICULAR DRUG DELIVERY
Pharmaceutical research has developed various new types of innovative forms of drug delivery. Advancement in current drug delivery methods has led to the development of numerous new revolutionary technologies that support safe and efficient formulations over existing ones. Novasome technology is one of the latest liposome developments that have overcome many of the liposomal drug delivery system-related problems. This provides a seven bilayer membrane which is capable of absorbing water-soluble as well as insoluble drugs. The improved efficiency of entrapping drugs with good encapsulation features enables better frequency of dosing, which can be accomplished through the high shear system. These find their applications in diverse fields such as cosmetics, chemicals, personal care, food, pharmacy, and agrochemicals. Several products have already been launched into the market using this technology with an additional launch plan. Due to its depth of penetration, novasomes have been one of the most popular derma cosmetics. It is being studied continuously to obtain improved release characteristics. The prospect of drug delivery and targeting using novasomes is an important area of research and development. This review pinpoints the various aspect of the novasome and will be a milestone for the researchers in the area of drug delivery.
2. Kalra. N, Dhanya. V, Saini V, Dr. Jeyabalan G, Virosomes: As a drug delivery carrier, American Journal of Advanced Drug Delivery, ISSN-2321-547X, 29-35, 2013.
3. Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharm Sin B. 2011; 1:208–19.
4. Shah JM, Shah NH, Hadia PD. Recent Advances in Novasome Formulation Technology. International Journal of Pharmaceutical Sciences and Nanotechnolgy 2014; 7:2.
5. Lasic, D.D., 1997. Liposomes and Niosomes. In: Surfactants in Cosmetics, Eds., M.M. Rieger and L.D. Rhein, Marcel Dekker: New York, pp: 263-283.
6. Gideon FA Kersten, Daan JA. Crommelin Liposomes and ISCOMs Vaccine 2003; 21:915-920.
7. Mark Chambers A. A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (NovasomeTM) protects guinea pigs from lethal tuberculosis Vaccine 2004; 22:1063-1071.
8. Swapnil Waghmare, Aarti Patil, Prachi Patil. Novasome: Advance in Liposome and Niosome. The Pharma Innovation Journal 2016; 5(5): 34-38.
9. Hadis Daraee, Ali Etemadi, Mohammad Kouhi, Samira Alimirzalu and Abolfazl Akbarzadeh; Application of liposomes in medicine and drug delivery, Artificial Cells, Nanomedicine, and Biotechnology, 2016; 44: 381–391.
10. Aiswarya M. U., Keerthana Raju, Revathy B. Menon, Lakshmi V. S., Sreeja C. Nair; Cryptosomes: a revolutionary breakthrough in novel drug delivery, International Journal of Applied Pharmaceutics, Vol 11, Issue 1, 2019.
11. Allen TM, Chonn A. 1987. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223:42–46.
12. Gajanan Shinde. International Journal of Drug Formulation and Research. 2011; 2:6.
13. Rampal RAJERA, Kalpana NAGPAL, Shailendra Kumar SINGH,* and Dina Nath MISHRA. Niosomes: A Controlled and Novel Drug Delivery System. Biol. Pharm. Bull. 34(7) 945-953, 2011.
14. Sweta agarwal*, dr. P.v. kamala kumari. Advances in novasome technology- a review. Internationl journal of applied pharmaceutics, Vol 5, Issue 1, 2013 .
15. Pinsky, M.A., 2010. Materials and Methods for Delivering Antioxidants into the Skin. U.S. Patent 20,100,098,752.
17. Lasic Handbook DD. of Biological Physics Volume 1, Edited By R. Lipowsky and E. Sackmann Ó1995 Elsevier Science.
19. Ali Nasir*, Harikumar SL and Kaur Amanpreet. Niosomes: an excellent tool for drug delivery, international journal of research in pharmacy and chemistry, 2012, 2(2).
20. Mills R, Mathur Rand Lawrence N (2007). Mahonia aquifolim extract, Extraction process and pharmaceutical composition containing the same. U.S. Patent 20,070,148,226.
21. Singh A et al. Novasome-A Breakthrough in Pharmaceutical Technology a Review Article. Advan. Biol. Res. 201; 5 (4): 184-189.
22. Wallach, D.F.H., R. Mathur, G.J.M. Redziniak and J.F. Tranchant. Some properties of N-acyl sarcosinate lipid vesicles. Journal of the Society of Cosmetic Chemists. 1992; 43(2): 113-8.
23. Frézard, F., 1999. Liposomes: From biophysics to the design of peptide vaccines. Brazilian J. Med. Biol. Res., 32(2): 181-189.
24. Mozafari MR. (Ed.), Nanomaterials and Nanosystems for Biomedical Applications, 2007, 67-81. ©Springer.
25. Rajesh Gupta K. Adjuvant properties of non-phospholipid liposomes (Novasome@) in experimental animals for human vaccine antigens Vaccine 1996; 14(3):219-225
26. Agarwal S, Dr. Kumari PVK. Advances in Novasome Technology- A Review. Int J App Pharm, 2013; 5(1): 1-4.
27. Anupama Singh, Rishabha Malviya, Pramod Kumar. Sharma Novasome-A Breakthrough in Pharmaceutical Technology a Review Article Advances in Biological Research 2011; 5(4):184-189.
28. Universe Cosmetics licenses ingredient release tech. Decision News Media. Available from: http://www.cosmeticsdesign.com.
29. Niemec, S., C. Ramachandran and N. Weiner, 1995. Influence of non ionic liposomal composition in topical delivery of peptide drugs into pilosebaceous units: An in vivo study using the hamster ear model. Pharmaceutical Research, 12(8): 1184-1188.
31. h tt p ://w w w. ph a r m a inf o. ne t/r e v ie w s /l ipo s o me- versatile-platform-targeted-delivery-drugs (Accessed July 28, 2010).
33. Nova Pearls Fresh Scent Deodorant Spray for Dogs and Cats. Drug Information Online Drugs.com. Available from: http://www.drugs.com.
34. Williams, A.C, Transdermal and topical drug delivery from theory to clinical practice.2003; Pharmaceutical Press: United Kingdom.
36. Buena, N.J., IGI Granted Patent on Novasome(R) Encapsulated Fuel Additives. The Free Library. Available from: http://www.thefreelibrary.com.
37. Gupta, R.K., C.L.Varanelli, P. Griffin, D.F.H. Wallach and G.R. Siber. Adjuvant properties of non-phospholipid liposomes (Novasomes®) in experimental animals for human vaccine antigens. Vaccine, 1996; 14(3): 219- 25.
38. Chambers, M.A., D.C. Wright, J. Brisker, A. Williams, G. Hatch, D. Gavier-Widén, G. Hall, P.D. Marsh and R.G. Hewinson. A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (Novasome™) protects guinea pigs from lethal tuberculosis. Vaccine, 2004; 22(6): 1063-71.
39. D.Craig Wright. Lipid vesicles having a bilayer containing a surfactant with anti-viral and spermicidal topical delivery of peptide drugs into activity.1997; U.S patent 5561062.
40. Pushko, P., T.M. Tumpey, N. Van Hoeven, J.A. Belser, R. Robinson, M. Nathan, G. Smith, D.C. Wright and R.A. Bright. Evaluation of influenza virus-like particles and Novasome adjuvant as candidate vaccine for avian influenza. Vaccine, 2007; 25(21): 4283-90.
41. Holick, M.F., F.N. Chimeh and S. Ray, 2003. Topical PTH (1–34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trial. British J. Dermatol., 149(2): 370-376.
42. Varanelli, C., S. Kumar and D.F.H. Wallach. Method of inhibiting viral reproduction using non-phospholipid, paucilamellar liposomes.1996; U.S. Patent 5,561,062.
43. Weiner, N., D.F.H. Wallach, K. Egbaria and R. Chandrasekharan. Stimulation of hair follicles. 1998; U.S. Patent 5,834,014.
44. Maya S, Sabitha M, Shanthikumar VN, Jayakumar R, Phytomedicine-loaded polymeric nanomedicines: potential cancer therapeutics, Advances in Polymer Science, 2013; 254: 203-239.
45. Malhotra M, Jain NK. Niosomes as drug carriers. Indian Drugs 1994;31:81-6.
46. Udupa N. Niosomes as drug carriers. In: Jain NK, editor. Controlled and novel drug delivery. 1st edition. New Delhi: CBS Publishers and Distributors; 2002.
47. Shefrin S, Sreelaxmi CS, Vijayan V, Nair SC, Enzymosomes: a rising effectual tool for targeted drug delivery system, International Journal Applied Pharmceutics, 2017; 9: 1-9.
48. Szoka Jr F, Papahadjopoulos D. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu Rev Biophys Bioeng 1980;9:467-508.
49. Revathy B Menon, Lakshmi VS, Aiswarya MU, Keerthana Raju, Sreeja C Nair, Porphysomes-a paradigm shift in targeted drug delivery, International Journal of Applied Pharmaceutics, 2018; 10: 1-6.
50. Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The Preparation and propereties of Niosomes-Non ionic surfactant vesicles. J Pharm Pharmacol 1985;37:863-8.
51. Hu C, Rhodes DG. Proniosomes: A Novel Drug Carrier Preparation. Int J Pharm 1999;185:23-35.
52. Sabitha M, Sanoj Rejinold N, Nair A, Lakshmanan VK, Nair SV, Jayakumar R, Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer, Carbohydrate Polymers, 2013; 91: 48-57.
53. Gregoriadis G, Engineering liposomes for drug delivery: progress and problems. Trends in Biotechnology. 1995; 13(12): 527-537.
This work is licensed under a Creative Commons Attribution 4.0 International License.