SILVER NANOPARTICLES AND COCONUT OIL INCORPORATED BIOPOLYMER BASED ELECTROSPUN NANOFIBERS FOR WOUND DRESSING

  • SUBHASHREE SAHOO PG STUDENT
  • JOGABRATA TRIPATHY PG STUDENT
  • AFRASIM MOIN ASSISTANT PROFESSOR
  • MEENAKSHI S ASSISTANT PROFESSOR
  • SIDDARAMAIAH Professor and HOD
  • D.V. GOWDA Professor and HOD

Abstract

The main aim of this study was to develop and evaluate the nanofiber loaded with coconut oil and silver nanoparticles (Ag NPs) for the treatment of wound healing by electro spun method. The silver nanoparticles are considered as a prominent bio material which can bring about anti-microbial properties and anti-bacterial activity. Hence, this can help us to formulate a Eudragit L-100/silver NPs based nanofibers for the purpose of wound healing. The electrospin nanofibers are light in weight, ranging from a nanometer to excess of 100 nm. Different evaluation parameters like Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), hydrophilicity test, biocompatibility of complex mixture and bactericidal activity of the electro spun fibers have been evaluated. The nanofibers are created using reduced form of silver nanoparticles and coconut oil along with Eudragit L-100 by the electrospin method. The morphological studies are carried out for the nanofibers along with chemical investigation of wound curing. The electrospin nanofibers are carried out for wetting investigation and in-vitro cytotoxicity test. The bactericidal activity has been carried out for zone of inhibition between Escherichia coli and Staphylococcus aureus. The formulated nanofibers offer protection against external agents and help in regeneration of new tissue.

Keywords: Polymeric nanofiber, Wound healing, electrospun meoli; Staphylococcusaureus.

Author Biographies

SUBHASHREE SAHOO, PG STUDENT

SUBHASHREE SAHOO

Department of Pharmaceutics

JSS College of Pharmacy

JSS Academy of Higher Education and Research, S.S. Nagara

Mysuru-570015

Karnataka

India

JOGABRATA TRIPATHY, PG STUDENT

JOGABRATA TRIPATHY

Department of Pharmaceutics

JSS College of Pharmacy, JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka

India

India

AFRASIM MOIN, ASSISTANT PROFESSOR

AFRASIM MOIN

Department of Pharmaceutics

College of Pharmacy, University of Hail

PO Box 2440

Hail, Saudi Arabia

MEENAKSHI S, ASSISTANT PROFESSOR

MEENAKSHI S

Department of Prosthodontics

JSS Dental College and Hospital

JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka

India

SIDDARAMAIAH, Professor and HOD

SIDDARAMAIAH

Department of Polymer Science and Technology

S. J. College of Engineering

JSS Science and Technology University

Mysuru-570006

Karnataka

India

D.V. GOWDA, Professor and HOD

D.V. GOWDA

Department of Pharmaceutics

JSS College of Pharmacy

JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka

India

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SAHOO, S., TRIPATHY, J., MOIN, A., MEENAKSHI S, SIDDARAMAIAH, & GOWDA, D. (2021). SILVER NANOPARTICLES AND COCONUT OIL INCORPORATED BIOPOLYMER BASED ELECTROSPUN NANOFIBERS FOR WOUND DRESSING. International Journal of Applied Pharmaceutics, 13(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/40291
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Original Article(s)