FORMULATION AND EVALUATION OF SOLID SELF MICRO EMULSIFYING DISPERSIBLE TABLET OF PIROXICAM
This study aimed to formulate the solid self-micro emulsifying dispersible tablets for promoting the dissolution of Piroxicam (PX). The solubility study of PX was conducted to know the solubility of various oil phase, surfactants, and co surfactants. A self-emulsifying grading test was performed by a visual grading system. Ternary phase diagrams and droplet size analysis were performed to screen and optimize the PX-self micro emulsifying drug delivery system (PX-SMEDS). Then microcrystalline cellulose KG802 was added as suitable adsorbent and dispersible tablets were prepared by wet granulation compression method. Finally, the composition of PX-SMEDS consisted of oil phase (oleic acid), surfactant (Cremophor R H-40), and co-surfactant (PEG-400) were selected. The dissolution study resulted that the PX-SMEDS dispersible tablets have increased the solubility compared to the pure PX.
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