FORMULATION AND EVALUATION OF SOLID SELF MICRO EMULSIFYING DISPERSIBLE TABLET OF PIROXICAM

  • GIRISH SH JSSAHER
  • AFRASIM MOIN Assistant Professor
  • SURABHI C Post Graduate Research Scholar
  • MEENAKSHI S Assistant Professor
  • SIDDARAMAIAH Professor
  • SATHISHBABU Research Scholar
  • NITHIN K S Assistant Professor
  • DV Gowda Professor

Abstract

This study aimed to formulate the solid self-micro emulsifying dispersible tablets for promoting the dissolution of Piroxicam (PX). The solubility study of PX was conducted to know the solubility of various oil phase, surfactants, and co surfactants. A self-emulsifying grading test was performed by a visual grading system. Ternary phase diagrams and droplet size analysis were performed to screen and optimize the PX-self micro emulsifying drug delivery system (PX-SMEDS). Then microcrystalline cellulose KG802 was added as suitable adsorbent and dispersible tablets were prepared by wet granulation compression method. Finally, the composition of PX-SMEDS consisted of oil phase (oleic acid), surfactant (Cremophor R H-40), and co-surfactant (PEG-400) were selected. The dissolution study resulted that the PX-SMEDS dispersible tablets have increased the solubility compared to the pure PX.

Keywords: Piroxicam, Solid self micro emulsifying system, Dispersible tablet.

Author Biographies

AFRASIM MOIN, Assistant Professor

Assistant Professor,

Department of Pharmaceutics,

College of Pharmacy,

University of Hail,

PO Box 2440,

Hail, Saudi Arabia.

SURABHI C, Post Graduate Research Scholar

Surabhi C,

Department of Pharmaceutics,

JSS College of Pharmacy,

JSS Academy of Higher Education & Research,

Mysuru - 570015, Karnataka, India.

MEENAKSHI S, Assistant Professor

MEENAKSHI S,

Assistant Professor,

Department of Prosthodontics,

JSS Dental College and Hospital,

JSS Academy of Higher Education & Research,

Mysuru - 570015, Karnataka, India.

SIDDARAMAIAH, Professor

Head Of the Department,

Department of Polymer Science and Technology,

S J College of Engineering,

JSS Science and Technology University,

Mysuru-570006,

Karnataka, India.

SATHISHBABU, Research Scholar

Research Scholar,

Department of Pharmaceutics,

JSS College of Pharmacy,

JSS Academy of Higher Education & Research,

Mysuru - 570015, Karnataka, India.

NITHIN K S, Assistant Professor

Assistant Professor,

Department of Chemistry,

The National Institute of Technology,

Mysuru - 570008, India

DV Gowda, Professor

Head Of The Department,

Department of Pharmaceutics,

JSS College of Pharmacy,

JSS Academy of Higher Education & Research,

Mysuru - 570015, Karnataka, India.

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How to Cite
SH, G., AFRASIM MOIN, SURABHI C, MEENAKSHI S, SIDDARAMAIAH, SATHISHBABU, NITHIN K S, & DV Gowda. (2021). FORMULATION AND EVALUATION OF SOLID SELF MICRO EMULSIFYING DISPERSIBLE TABLET OF PIROXICAM. International Journal of Applied Pharmaceutics, 13(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/40238
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Original Article(s)

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