IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-HYDROXY PROPYL ß-CYCLODEXTRIN INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY

  • JOGABRATA TRIPATHY PG Student
  • SUBHASHREE SAHOO PG Student
  • AFRASIM MOIN Asst. Professor
  • SIDDARAMAIAH PROFESSOR AND HOD
  • D V GOWDA PROFESSOR AND HOD

Abstract

The aim of the study was to develop and evaluate orally disintegrating tablet that contain pilocarpine and 2-hydroxy propyl ß-cyclodextrin as an inclusion complex that are prepared by lyophilisation used for treatment for dry mouth. Pilocarpine is utilised to treat dry mouth disorder. The inclusion complex lowers the taste of pilocarpine through the oral mucosa by use of 2-hydroxy propyl ß-cyclodextrin. The study of phase solubility can be carried out by using an appropriate formula. The in-vitro release from insertion complex is also been studied. The parameters like differential scanning calorimetry (DSC), Fourier transformer infrared (FTIR) Spectroscopy, X-ray diffraction (XRD) and morphological study have been evaluated. The design of experiment is carried out based on concentration of croscarmellose sodium and microcrystalline cellulose (MCC). Evaluation of the prepared orally disintegrating tablets have been carried out by different test methods like weight variation, thickness, drug content, disintegration and in-vitro dissolution study. The statistical analysis helps to obtain the optimised formulation. Orally disintegrating tablets are studied by utilising the immediate pressure technique. The different diluents and super disintegrating have been applied for quick elevation of dry mouth that helps us for patient compliance.

Keywords: Nil

Author Biographies

JOGABRATA TRIPATHY, PG Student

JOGABRATA TRIPATHY

Department of Pharmaceutics

JSS College of Pharmacy, JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka, India

SUBHASHREE SAHOO, PG Student

SUBHASHREE SAHOO

Department of Pharmaceutics

JSS College of Pharmacy, JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka, India

AFRASIM MOIN, Asst. Professor

AFRASIM MOIN

Assistant Professor

Department of Pharmaceutics

College of Pharmacy, University of Hail

PO Box 2440

Hail, Saudi Arabia

SIDDARAMAIAH, PROFESSOR AND HOD

SIDDARAMAIAH

PROFESSOR AND HOD

Department of Polymer Science and Technology

S.J. College of Engineering, JSS Science and Technology University

Mysuru-570006

Karnataka, India.

 

D V GOWDA, PROFESSOR AND HOD

D V GOWDA

Department of Pharmaceutics

JSS College of Pharmacy, JSS Academy of Higher Education and Research

S.S. Nagara, Mysuru-570015

Karnataka, India.

 

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How to Cite
Tripathy, J., SAHOO, S., MOIN, A., SIDDARAMAIAH, & GOWDA, D. V. (2021). IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-HYDROXY PROPYL ß-CYCLODEXTRIN INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY. International Journal of Applied Pharmaceutics, 13(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/40292
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Original Article(s)

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