SOLUBILITY AND DISSOLUTION ENHANCEMENT OF PIOGLITAZONE USING SOLID DISPERSION TECHNIQUE


Bhushan A. Bhairav, Lalit R. Jagtap, R. B. Saudagar

Abstract


Objective: To design the study to improve the solubility and hence enhance the dissolution of hydrophobic drug Pioglitazone in order to increase its bioavailability.

Methods: Solid dispersion of Pioglitazone using carriers Poloxomer 188 and HPβCD was formulated in different ratios by microwave induced fusion method. In particular, the Microwave technology has been considered in order to prepare an enhanced release dosage form for poorly water soluble drug Pioglitazone. Statistical Analysis: Their physicochemical characteristics and solubility were compared to the corresponding dispersions and marketed drug. Drug and polymer were further characterized by FTIR.

Results: The results of FTIR revealed that no chemical interaction between the drug and the polymer exist.

Conclusion: All the formulations showed a marked increase in drug release with the increase in the concentration of Poloxomer 188 and HPβCD.

 


Keywords


Pioglitazone, Solid dispersion, Microwave Irradiation Method, Poorly water soluble drugs.

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References


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About this article

Title

SOLUBILITY AND DISSOLUTION ENHANCEMENT OF PIOGLITAZONE USING SOLID DISPERSION TECHNIQUE

Keywords

Pioglitazone, Solid dispersion, Microwave Irradiation Method, Poorly water soluble drugs.

DOI

10.22159/ijcpr.2017v9i5.22326

Date

21-09-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 5 (Aug-Sep), 2017 Page: 186-193

Online ISSN

0975-7066

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Authors & Affiliations

Bhushan A. Bhairav
Department of Quality Assurance and Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal. Trimbakeshwar, Dist. Nashik 422213, Maharashtra, India
India

Lalit R. Jagtap
Department of Quality Assurance and Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal. Trimbakeshwar, Dist. Nashik 422213, Maharashtra, India
India

R. B. Saudagar
Department of Quality Assurance and Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal. Trimbakeshwar, Dist. Nashik 422213, Maharashtra, India
India


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