IN VITRO HEPATOPROTECTIVE ACTIVITY OF YELLOW LEAF EXTRACTS OF THESPESIA POPULNEA AGAINST CARBON TETRACHLORIDE INDUCED TOXICITY

  • UMADEVI A. Department of Pharmacognosy, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India
  • P. AJITH KUMAR Department of Pharmacognosy, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India

Abstract

Objective: The study was aimed to evaluate in vitro hepatoprotective activity of yellow leaf extracts of Thespesiapopulnea.


Methods: Hepatoprotective activity is studied by carbon tetrachloride-induced hepato-toxicity in isolated rat hepatocytes. The biochemical parameters observed in serum were serum glutamate oxaloacetate transaminase (SGOT/AST), serum glutamate pyruvate transaminase (SGPT/ALT) levels. The extracts exhibited a dose-dependent reduction in AST, ALT levels.


Results: Methanolic extract was found to exhibit higher hepatoprotection. T. populnea extract was found to be antihepatotoxic at a concentration of 125 mcg with a significant decrease in ALT (P<0.001) and AST (P<0.0001).


Conclusion: The results suggest that the methanolic extract has produced significant (p<0.001) hepatoprotection by decreasing the activity of serum enzymes which is comparable to that of standard drug silymarin.

Keywords: Thespesiapopulnea, Methanolic extract, Hepatoprotective activity

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How to Cite
A., U., and P. A. KUMAR. “IN VITRO HEPATOPROTECTIVE ACTIVITY OF YELLOW LEAF EXTRACTS OF THESPESIA POPULNEA AGAINST CARBON TETRACHLORIDE INDUCED TOXICITY”. International Journal of Current Pharmaceutical Research, Vol. 11, no. 3, May 2019, pp. 21-23, doi:10.22159/ijcpr.2019v11i3.34087.
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