SIMULTANEOUS ESTIMATION OF IRBESARTAN AND ATORVASTATIN BY Q ABSORPTION RATIO METHOD IN THEIR SYNTHETIC MIXTURE USE IN CARDIAC CONDITION


Paras Virani

Abstract


A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture using Q absorption Ratio Method. In this spectroscopic  method, 234.7 nm (as an iso-absorptive point) and 226 nm wavelengths (λmax of any of the two drugs) were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 μg/ml at their respective λmax and at the isoabsorptive point. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.365μg/ml and 0.0622μg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 1.108μg/ml and 0.188μg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 100.51% and 100.16% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.


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References


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About this article

Title

SIMULTANEOUS ESTIMATION OF IRBESARTAN AND ATORVASTATIN BY Q ABSORPTION RATIO METHOD IN THEIR SYNTHETIC MIXTURE USE IN CARDIAC CONDITION

Date

01-01-2015

Additional Links

Manuscript Submission

Journal

Innovare Journal of Education
Vol 3 Issue 1 2015 ( Jan-Mar) Page: 20-24

Online ISSN

2347-5528

Statistics

27 Views | 28 Downloads

Authors & Affiliations

Paras Virani
India


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