EVALUATION OF ANTIHYPERLIPIDEMIC, ANTI-INFLAMMATORY, AND ANALGESIC ACTIVITIES OF EURYCOMA LONGIFOLIA IN ANIMAL MODELS


Phebe Hendra, Fenty ., Putu Ririn Andreani, Bernadetha Maria Estika Pangestuti, Jeffry Julianus

Abstract


Objective: To investigate the antihyperlipidemic, anti-inflammatory and analgesic properties of of E. longifolia root extract in animal models.

Methods: In this study, glucose-fructose enriched diet-induced hyperlipidemia, carrageenan-induced paw edema and acetic acid-induced writhing were used to evaluate the anti-hypertriglyceridemia, anti-inflammatory and analgesic activities, respectively. At the end of the experiment of glucose-fructose enriched diet-induced hyperlipidemia, blood samples were collected and estimation of blood lipids were carried out. Edema thickness was measured using digital caliper at 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, and 360 min after carrageenan injection. The number of abdominal writhing for each mouse was observed and counted during a period of 1 h post injection of acetic acid.

Results: E. longifolia root extract demonstrated a significant reduction of triglyceride levels (p<0.05) compared with the control group in glucose-fructose enrich diet in rats. In anti-inflammatory test, the extract significantly inhibited the carrageenan induced paw edema formation (p<0.05). The extract also significantly decreased the number of writhing in acetic acid-induced mice (p<0.05).

Conclusion: E. longifolia root extract shown a significant anti-hypertriglyceridemia, anti-inflammatory and analgesic activities. Further studies are needed to determine mechanisms for its acitivities of E. longifolia root extract.


Keywords


Eurycoma longifolia, Antihypertriglyceridemia, Anti-inflammatory, Analgesic

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About this article

Title

EVALUATION OF ANTIHYPERLIPIDEMIC, ANTI-INFLAMMATORY, AND ANALGESIC ACTIVITIES OF EURYCOMA LONGIFOLIA IN ANIMAL MODELS

Keywords

Eurycoma longifolia, Antihypertriglyceridemia, Anti-inflammatory, Analgesic

DOI

10.22159/ijpps.2017v9i3.16366

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 166-169

Online ISSN

0975-1491

Statistics

128 Views | 88 Downloads

Authors & Affiliations

Phebe Hendra
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia
Indonesia

Fenty .
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia

Putu Ririn Andreani
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia

Bernadetha Maria Estika Pangestuti
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia

Jeffry Julianus
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia
Indonesia


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