EVALUATION OF ANTIDIABETIC AND ANTI HYPERLIPIDEMIC ACTIVITIES OF MACARANGA TANARIUS IN RATS FEED WITH HIGH GLUCOSE-FRUCTOSE DIET

  • Phebe Hendra Faculty of Pharmacy Sanata Dharma University, Yogyakarta, Indonesia
  • Fenty . . Sanata Dharma University
  • Jeffry Julianus Sanata Dharma University

Abstract

Objective: Macaranga tanarius showed a potent α–glucosidase inhibitors that may benefit diabetes treatment. The hexane-ethanol fraction of methanol extract of Macaranga tanarius was investigated for antidiabetic, and anti hiperlidemia activity in rats feed with high glucose-fructose diet.

Methods: After induced with high glucose-fructose diet for 42 d, the rats were treated with the hexane-ethanol fraction of methanol extract of Macaranga tanarius at doses of 34.2, 78.5, 137 mg/kg per oral once in a day for 5 d and high glucose-fructose diet consecutively. Fasting blood glucose, cholesterol, triglyceride, HDL and LDL concentration were evaluated at the next day after treatment.

Results: The 5 d administration of hexane-ethanol fraction of methanol extract of Macaranga tanarius did not produce any significant difference in any of the assigned parameters between the diet and all dose groups.

Conclusion: The hexane-ethanol fraction of methanol extract of Macaranga tanariusat all level has not antidiabetic and anti hiperlidemia activity in rats feet with high glucose-fructose diet.

 

Keywords: Macaranga tanarius, antidiabetic, Antihiperlipedmia, Glucose-fructose

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How to Cite
Hendra, P., F. . ., and J. Julianus. “EVALUATION OF ANTIDIABETIC AND ANTI HYPERLIPIDEMIC ACTIVITIES OF MACARANGA TANARIUS IN RATS FEED WITH HIGH GLUCOSE-FRUCTOSE DIET”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 1, Dec. 2015, pp. 462-3, https://innovareacademics.in/journals/index.php/ijpps/article/view/9560.
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