A PROSPECTIVE CLINICALTRIAL OF AMLODIPINE IN COMPARISON TO PERINDOPRIL

  • Suprava Das Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
  • Myat Thu Thuwin Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
  • Sherly Deborah G. Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
  • Lubnashirin . Faculty of Medicine, QUEST International University Perak, Ipoh, Perak, Malaysia
  • Mohammad Shahjahan Kabir Faculty of Medicine, QUEST International University Perak, Ipoh, Perak, Malaysia
  • Sridevi Chigurupati Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, Malaysia

Abstract

Objective: The objective of this research was to perform a prospective clinical trial to compare antihypertensive effects of amlodipine and perindopril in hypertensive patients.

Methods: In our study, we compared antihypertensive effects of well tolerated and commonly used antihypertensive drugs, amlodipine and perindopril. There were 81 hypertensive patients of both sexes over 40 y of age without other diseases included in this prospective clinical trial. Forty (40) patients were treated with amlodipine (5 mg/day) and forty-one (41) patients were treated with perindopril (4 mg/day). After one month of taking both drugs, blood pressure was measured in the supine position with a standard mercury sphygmomanometer in the morning.

Results: Amlodipine and perindopril groups were having almost similar characteristics at the beginning of the study. There was significantly decrease insystolic blood pressure (sBP) throughout the study period in the amlodipine group (p≤ 0.05) but not in the perindopril group. The efficacy of amlodipine over perindopril on systolic blood pressure and diastolic blood pressure (dBP) was significant (p≤ 0.001 for sBP and p≤ 0.05 for dBP).

Conclusion: It may be concluded that the antihypertensive efficacy of amlodipine was superior when compared to perindopril.

Keywords: Amlodipine, Perindopril, Comparative efficacy, Hypertension

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References

1. Kotchen, Theodore A. Hypertensive vascular disease. In: LongoDan L, Fauci Anthony S, Kasper Dennis L, Hauser Stephen L, Jameson J Larry, Loscalzo Joseph. editors. Harrison’s Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012. p. 2042-59.
2. Walker Brian R, Colledge Nicki R, Ralston Stuart H, Penman Ian D. editors. Davidson's Principles and Practice of Medicine. 22nd Edition. NewYork: Elsevier Health Sciences; 2014. p. 607-13.
3. Sayeed MA, Banu A, Haq JA, Khanam PA, Mahtab H, Azad KA. Prevalence of hypertension in Bangladesh: effect of socioeconomic risk factor on difference between rural and urban community. Bangladesh Med Res Counc Bull 2002;28:7-18.
4. Missiriya S, John J. Assess the prevalence of hypertension and knowledge regarding the prevention of stroke. Asian J Pharm Clin Res 2017;10:177-80.
5. Gu Q, Burt VL, Dillon CF, Yoon S. Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension. Circulation 2012;126:2105-14.
6. Huang R, Feng Y, Wang Y, Qin X, Melgiri ND, Sun Y, et al. Comparative efficacy and safety of antihypertensive agents for adult diabetic patients with microalbuminuric kidney disease: a network meta-analysis. PloS One 2017;12:e0168582.
7. Moura CS, Daskalopoulou SS, Levesque LE, Bernatsky S, Abrahamowicz M, Tsadok MA, et al. Comparison of the effect of thiazide diuretics and other antihypertensive drugs on central blood pressure: cross‐sectional analysis among nondiabetic patients. J Clin Hypertens (Greenwich) 2015;17:848-54.
8. Bertrand ME. Perindopril/amlodipine combination: an optimal synergy for cardiovascular protection. Eur Heart J Suppl 2009;11 Suppl:22-5.
9. Guazzi MD, Campodonico J, Celeste F, Guazzi M, Santambrogio G, Rossi Metal. Antihypertensive efficacy of angiotensin converting enzyme inhibition and aspirin counteraction. Clin Pharmacol Ther 1998;63:79-86.
10. Bhardwaj S, Balgir PP, Goel RK. Pharmacogenomics and personalized management of hypertension. J Crit Rev 2015;2:1-6.
11. Furn Daniel E, Ulrich Robert W. Nonsteroidal anti-inflammatory, disease-modifying antirheumatic drugs, nonopioid analgesics and drugs used in gout. In: Katzung Bartram G. editor. Basic and Clinical Pharmacology. 10th ed. New York: McGraw-Hill; 2007. p. 621-25.
12. Horn JR, Hansten PD. NSAIDs and antihypertensive agents. Pharm Times 2016;72:111.
13. Rutuparna P, Merin D, Abraham S, Thomas NM, Hameed J. Assessment of clinical effectiveness of losartan and amlodipine in hypertensive patients with left ventricular hypertrophy. Asian J Pharm Clin Res 2017;10:368-71.
14. Jose A, Wilson D, George M, Thomas RK, Justin A. Comparative study on the beneficial effects of telmisartan and other antihypertensive agents in stroke patients. Int J Pharm Pharm Sci 2014;9:99-102.
15. Bronsert MR, Henderson WG, Valuck R, Hosokawa P, Hammermeister K. Comparative effectiveness of antihypertensive therapeutic classes and treatment strategies in the initiation of therapy in primary care patients: a distributed ambulatory research in therapeutics network (DARTNet) study. J Am Board Fam Med 2013;26:529-38.
16. Wang JG, Pimenta E, Chwallek F. Comparative review of the blood pressure-lowering and cardiovascular benefits of telmisartan and perindopril. Vasc Health Risk Manag 2014;10:189-200.
17. Wu HY, Huang JW, Lin HJ, Liao WC, Peng YS, Hung KY, et al. Comparative effectiveness of renin-angiotensin system blockers and other antihypertensive drugs in patients with diabetes: systematic review and bayesian network meta-analysis. Br Med J 2013;347:f6008.
18. Zannad F, Bernaud CM, Fay R. Double‐blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension. J Hypertens 1999;17:137-46.
19. Eguchi K, Kario K, Hoshide Y, Hoshide S, Ishikawa J, Morinari M, et al. Comparison of valsartan and amlodipine on ambulatory and morning blood pressure in hypertensive patients. Am J Hypertens 2004;17:112-7.
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Das, S., M. T. Thuwin, S. D. G., L. ., M. S. Kabir, and S. Chigurupati. “A PROSPECTIVE CLINICALTRIAL OF AMLODIPINE IN COMPARISON TO PERINDOPRIL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 9, no. 12, Dec. 2017, pp. 268-70, doi:10.22159/ijpps.2017v9i12.22270.
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