A PROSPECTIVE CLINICALTRIAL OF AMLODIPINE IN COMPARISON TO PERINDOPRIL


Suprava Das, Myat Thu Thuwin, Sherly Deborah G., Lubnashirin ., Mohammad Shahjahan Kabir, Sridevi Chigurupati

Abstract


Objective: The objective of this research was to perform a prospective clinical trial to compare antihypertensive effects of amlodipine and perindopril in hypertensive patients.

Methods: In our study, we compared antihypertensive effects of well tolerated and commonly used antihypertensive drugs, amlodipine and perindopril. There were 81 hypertensive patients of both sexes over 40 y of age without other diseases included in this prospective clinical trial. Forty (40) patients were treated with amlodipine (5 mg/day) and forty-one (41) patients were treated with perindopril (4 mg/day). After one month of taking both drugs, blood pressure was measured in the supine position with a standard mercury sphygmomanometer in the morning.

Results: Amlodipine and perindopril groups were having almost similar characteristics at the beginning of the study. There was significantly decrease insystolic blood pressure (sBP) throughout the study period in the amlodipine group (p≤ 0.05) but not in the perindopril group. The efficacy of amlodipine over perindopril on systolic blood pressure and diastolic blood pressure (dBP) was significant (p≤ 0.001 for sBP and p≤ 0.05 for dBP).

Conclusion: It may be concluded that the antihypertensive efficacy of amlodipine was superior when compared to perindopril.


Keywords


Amlodipine, Perindopril, Comparative efficacy, Hypertension

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About this article

Title

A PROSPECTIVE CLINICALTRIAL OF AMLODIPINE IN COMPARISON TO PERINDOPRIL

Keywords

Amlodipine, Perindopril, Comparative efficacy, Hypertension

DOI

10.22159/ijpps.2017v9i12.22270

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 12, 2017 Page: 268-270

Online ISSN

0975-1491

Statistics

12 Views | 6 Downloads

Authors & Affiliations

Suprava Das
Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
Malaysia

Myat Thu Thuwin
Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
Malaysia

Sherly Deborah G.
Faculty of Medicine, AIMST University, Semeling, Bedong, Kedah, Malaysia
Malaysia

Lubnashirin .
Faculty of Medicine, QUEST International University Perak, Ipoh, Perak, Malaysia
Malaysia

Mohammad Shahjahan Kabir
Faculty of Medicine, QUEST International University Perak, Ipoh, Perak, Malaysia
Malaysia

Sridevi Chigurupati
Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, Malaysia
Malaysia


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