• ALI MOHAMMED ABDULLAH BAWAZIR Department of Studies and Research in Microbiology, Post Graduate Centre, Mangalore University, Jnana Kaveri, Chikka Aluvara, Kodagu 571232, Karnataka, India,
  • PALAKSHA Department of Studies and Research in Biochemistry, Post Graduate Centre, Mangalore University, Jnana Kaveri, Chikka Aluvara, Kodagu 571232, Karnataka, India
  • MANJULA SHANTARAM Department of Studies and Research in Biochemistry, Post Graduate Centre, Mangalore University, Jnana Kaveri, Chikka Aluvara, Kodagu 571232, Karnataka, India



Actinomycetes, Antibiotics, Natural pigments, Enzymes


This review conceptualizes about the actinomycetes and its contribution to human health by playing a key role as bioactive secondary metabolites, such as enzymes, antibiotics and pigments, leading to their diverse applications and use in various industries. These searches have been uncommonly successful, and around 66% of naturally happening antibiotics, including many medically important, have been isolated from actinomycetes. The speedy occurrence of antimicrobial resistance among pathogens has led to a renewed interest to search for novel antimicrobial agents, but these antibiotics are not enough for the treatment of all diseases because there is a berserk requirement for a novel actinomycetes to combat against the antibiotic-resistant strains of pathogenic microorganisms, which are quickly expanding bit by bit. Actinomycetes are the important providers to the pharmaceutical and other industries and are well known for their capacity to produce secondary metabolites many of which are active against pathogenic microorganisms.


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Gottlieb D. General consideration and implications of the actinomycetales. In: Actinomycetales, characteristics and practical importance, Academic Press: London and New York; 1973. p. 1-10.

Das S, Lyla PS, Khan SA. Distribution and generic composition of culture-able marine actinomycetes from the sediments of Indian continental. Bengal Chinese J Oceanol Limnol 2008; 26:166-77.

Lechevalier HA, Lechevalier MP. Biology of actinomycetes. Ann Rev Microbiol 1967;21:71-99.

Goodfellow M, Williams ST. Ecology of actinomycetes. Ann Rev Microbiol 1983;37:189-216.

Stackebrandt E, Goebel BM. Taxonomic note: a place for DNA-DNA re-association and 16s r RNA sequence analysis in the present species definition in bacteriology. Int J Syst Bacteriol 1994;44:846-9.

Okami Y, Hotta K. Search and discovery of new antibiotics in actinomycetes in Biotechnology. Edited by M Goodfellow, ST Williams, M Mordarski. London: Academic Press; 1988. p. 33-67, 89-210.

Nolan RD, Cross T. In: Actinomycetes in Biotechnology. Goodfellow M, Williams ST, Mordarski M. Eds. Academic Press: London; 1988. p. 1-32.

Igarashi Y. Screening of novel bioactive compounds from plant-associated actinomycetes. Actinomycetol 2004;18:63-6.

Mukku VJ, Speitling M, Laatsch H, Helmke E. New butenolides from two marine streptomycetes. J Nat Prod 2000;63:1570-2.

Mitra A, Santra SC, Mukherjee J. Distribution of actinomycetes, their antagonistic behavior and the physicochemical characteristics of the world’s largest tidal mangrove forest. Appl Microbiol Biotechnol 2008;80:685-95.

Promnuan Y, Kudo T, Chantawannakul P. Actinomycetes isolated from beehives in Thailand. World J Microbiol Biotechnol 2009;25:1685-9.

Radhakrishnan M, Suganya S, Balagurunathan R, Kumar V. Preliminary screening for antibacterial and antimycobacterial activity of actinomycetes from less explored ecosystems. World J Microbiol Biotechnol 2010;26:561-6.

Mohammed AM. Antibiotics: bacterial resistance to antibiotics. Ammaan Jordan 2011;358:135-8.

Oskay M, Same A, Azeri C. Antibacterial activity of some actinomycetes isolated from farming soils of turkey. Afr J Biotechol 2004;3:441-6.

Vandemme EJ. Biotechnology of industrial antibiotics. Dekker Series, Marcel Dekker Inc, New York 1948;22:3-42.

Jose PA, Jebakumar SRD. Non-streptomycete actinomycetes nourish the current microbial antibiotic drug discovery. FMICB 2013;4:240.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 y from 1981 to 2010. J Nat Prod 2012;75:311-35.

Demain AL, Sanchez S. Microbial drug discovery: 80 y of progress. J Antibiot 2009;62:5-16.

Fleming A. On the antibacterial action of cultures of penicillium, with special reference to their use in the isolation of B. influenzae. Br J Exp Pathol 1929;10:226-36.

Chain E, Florey HW, Gardner AD, Heatley NG, Jennings MA, Orr-Ewing J, et al. Penicillin as a chemotherapeutic agent. Lancet 1940;2:226-8.

Waksman SA, Woodruff HB. Bacteriostatic and bacteriocidal substances produced by soil actinomycetes. Proc Soc Exp Biol 1940;45:609-14.

Waksman SA. Production and activity of streptothricin. J Bacteriol 1943;46:299-310.

Comroe JH Jr. Pay dirt: the story of streptomycin. I: from Waksman to Waksman. Retrospectroscope Am Rev Respir Dis 1978;117:773-81.

Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004;67:2141-215.

Berdy J. Bioactive microbial metabolites. J Antibiot 2005;58:1-26.

Hamaki T, Suzuki M, Fudou R, Jojima Y, Kajiura T, Tabuchi A, et al. Isolation of novel bacteria and actinomycetes using soil-extract agar medium. J Biosci Bioeng 2005;99:485-92.

Jose PA, Santhi VS, Jebakumar SRD. Phylogenetic-affiliation, antimicrobial potential and PKS gene sequence analysis of moderately halophilic Streptomyces sp. inhabiting an Indian saltpan. J Basic Microbiol 2011;51:348-56.

Mohamed SH, Galal AM. Identification and antiviral activities of some halotolerant streptomycetes isolated from Qaroon Lake. Int J Agric Biol 2005;5:747-53.

Mahajan GB, Balachandran L. Antibacterial agents from actinomycetes–a review. Front Biosci 2012;E4:240-53.

Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discovery 2005;4:206-20.

Seong CN, Choi JH, Baikm KS. An improved selective isolation of rare actinomycetes from forest soil. J Microbiol 2001;39:17-23.

Tiwari K, Gupta RK. Rare actinomycetes: a potential storehouse for novel antibiotics. Crit Rev Biotechnol 2012;32:108-32.

Beltrametti F, Lazzarini A, Brunati C, Marazzi A, Jovetic S, Selva E, et al. Production and characterization of mono-chlorinated and dechlorinated A40926 derivatives. J Antibiot 2003;56:773-82.

Jose PA, Jebakumar SRD. Phylogenetic diversity of actinomycetes culturedfrom coastal multipond solar saltern in Tuticorin, India. Aquat Biosyst 2012;8:23.

Flatt PM, Wu X, Perry S, Mahmud T. Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. J Nat Prod 2013;76:939-46.

Fu P, Liu P, Li X, Wang Y, Wang S, Hong K, et al. Cyclic bipyridine glycosides from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-2216. Org Lett 2011;13:5948-51.

Wang XJ, Zhang J, Wang JD, Qian PT, Liu CX, Xiang WS. Novel cyclopentenone derivatives produced by a rare actinobacterial strain Actinoalloteichus nanshanensis sp. nov. NEAU 119. Nat Prod Res 2013. Doi:10.1080/14786419.771349.

Oh DC, Poulsen M, Currie CR, Clardy J. Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat Chem Biol 2009;5:391-3.

Barke J, Seipke RF, Grüschow S, Heavens D, Drou N, Bibb MJ, et al. A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus. BMC Biol 2010;8:109.

Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. J Nat Prod 2012;75:1806-9.

Murakami R, Shinozaki J, Kajiura T, Kozone I, Takagi M, Shin Ya K, et al. Ammocidins, B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571. J Antibiot 2009;62:123-7.

Aouiche A, Sabaou N, Meklat A, Zitouni A, Bijani C, Mathieu F, et al. Saccharothrix sp. PAL54, a new chloramphenicol-producing strain isolated from a saharan soil. World J Microbiol Biotechnol 2012;28:943-51.

Nakae K, Kurata I, Kojima F, Igarashi M, Hatano M, Sawa R, et al. Sacchathridine, A, a prostaglandin release inhibitor from Saccharothrix sp. J Nat Prod 2013;76:720-2.

Lazzarini A, Cavaletti L, Toppo G, Marinelli F. Rare genera of actinomycetes as potential producers of new antibiotics. Antonie Van Leeuwenhoek 2001;79:399-405.

Hayakawa H. Studies on the isolation and distribution of rare actinomycetes in soil. Actinomycetologica 2008;22:12-9.

Tiwari K, Gupta RK. Diversity and isolation of rare actinomycetes: an overview. Crit Rev Biotechnol 2013;39:256-94.

Gu Q, Paœciak M, Luo H, Gamian A, Liu Z, Huang Y. Ruania albidiflava gen. nov., sp. nov., a novel member of the suborder micrococcineae. Int J Syst Evol Microbiol 2007;57:809-14.

Li WJ, Xu P, Schumann P, Zhang YQ, Pukall R, Xu LH, et al. Georgenia ruanii sp. nov., a novel actinobacterium isolated from forest soil in Yunnan (China), and emended description of the genus georgenia. Int J Syst Evol Microbiol 2007;57:1424-8.

Li J, Zhao GZ, Huang HY, Zhu WY, Lee JC, Kim CJ, et al. Pseudonocardia rhizophila sp. nov., a novel actinomycete isolated from a rhizosphere soil. Antonie Van Leeuwenhoek 2010;98:77-83.

Ara I, Bakir MA, Hozzein WN, Kudo T. Population morphological and chemotaxonomical characterization of diverse rare actinomycetesin the mangrove and medicinal plant rhizosphere. Afr J Microbiol Res 2013;7:1480-8.

Qin S, Li J, Chen HH, Zhao GZ, Zhu WY, Jiang CL, et al. Isolation, diversity, and antimicrobial activity of rare actinobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China. Appl Environ Microbiol 2009;75:6176-86.

Janso JE, Carter GT. Biosynthetic potential of phylogenetically unique endophytic actinomycetes from tropical plants. Appl Environ Microbiol 2010;76:4377-86.

Zhao GZ, Li J, Huang HY, Zhu WY, Zhao LX, Tang SK, et al. Pseudonocardiaartemisiae sp. nov, isolated from surface-sterilized Artemisia annua L. Int J Syst Evol Microbiol 2011;61:1061-5.

Zhang H, Lee YK, Zhang W, Lee HK. Culturable actinobacteria from the marine sponge Hymeniacidon perleve: isolation and phylogenetic diversity by 16S rRNA gene-RFLP analysis. Antonie Van Leeuwenhoek 2006;90:159-69.

Sun W, Dai S, Jiang S, Wang G, Liu G, Wu H, et al. Culture-dependent and culture-independent diversity of actinobacteria associated with the marine sponge Hymeniacidon perleve from the South China Sea. Antonie Van Leeuwenhoek 2010;98:65-75.

Radhakrishnan M, Balagurunathan R, Selvakumar N, Doble M, Kumar V. Bioprospecting of marine derived actinomycetes with special reference to antimycobacterial activity Indian. J Geo Marine Sci 2011;40:407-10.

Goodfellow M, Stach JE, Brown R, Bonda AN, Jones AL, Mexson J, et al. Verrucosispora maris sp. nov., a novel deep sea actinomycete isolated from a marine sediment which produces abyssomicins. Antonie Van Leeuwenhoek 2012;101:185-93.

Jose PA, Jebakumar SRD. Phylogenetic appraisal of antagonistic, slow growing actinomycetes isolated from hypersaline inland solar salterns at sambhar salt lake, India. Front Microbiol 2013;4:190.

Lee DW, Lee SD. Allocatelliglobosispora scoriae gen. nov, sp. nov, isolated from volcanic ash. Int J Syst Evol Microbiol 2011;61:264-70.

Okoro CK, Brown R, Jones AL, Andrews BA, Asenjo JA, Goodfellow M, et al. Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile. Antonie Van Leeuwenhoek 2009;95:121-33.

Reddy GSN, Pradhan S, Manorama R, Shivaji S. Cryobacterium roopkundensesp. nov., a psychrophilic bacterium isolated from glacial soil. Int J Syst Evol Microbiol 2010;60:866-70.

Zhang DC, Schumann P, Redzic M, Zhou YG, Liu HC, Schinner F, et al. Alpinus sp. nov., a psychrophilic actinomycete isolated from alpine glacier cryoconite. Int J Syst Evol Microbiol 2012;62:445-50.

Nawani N, Aigle B, Mandal A, Bodas M, Ghorbel S. Actinomycetes: role in biotechnology and medicine. BioMed Res Int 2013.

Pieper R, Huang ST, Suh MJ. Proteomics and metaproteomics. Encycl Metagen 2014;8:1-11.

Mukhtar S, Zaheer A, Aiysha D, Abdulla Malik K, Mehnaz S. Actinomycetes: a source of industrially important enzymes. J Proteomics Bioinform 2017;10:316-19.

Kar S, Ray RC. Statistical optimization of a-amylase production by Streptomyces erumpens MTCC 7317 cells in calcium alginate beads using response surface methodology. Pol J Microbiol 2008;57:49-57.

Yang CH, Liu P. Purification and properties of a maltotriose-producing alpha-amylase from thermobifida fusca. Enzyme Microb Technol 2004;35:254-60.

Bentley SD, Chater KF, Cerdeno Tarraga AM, Challis GL, Thomson NR, et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3. Nature 2002;417:141-7.

Wietzorrek A, Bibb M. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 1997;25:1181-4.

Habbeche A, Saoudi B, Jaouadi B, Haberra S, Kerouaz B. Purification and biochemical characterization of a detergent-stable keratinase from a newly thermophilic actinomycete Actinomadura keratinilytica strain Cpt29 isolated from poultry compost. J Biosci Bioeng 2014;117:413-21.

Zhang F, Chen JJ, Ren WZ, Nie GX, Ming H. Cloning, expression and characterization of an alkaline thermostable GH9 endoglucanase from Thermobifida halotolerans YIM 90462 T. Biores Technol 2011;102:10143-6.

El-Sersy NA, Abd-Elnaby H, Abou-Elela GM, Ibrahim HAH, El-Toukhy NMK. Optimization, economization and characterization of cellulose produced by marine Streptomyces ruber. Afr J Biotechnol 2010;9:6355-64.

Priya BS, Stalin T, Selvam K. Efficient utilization of xylanase and lipase producing thermophilic marine actinomycetes (Streptomyces albus and Streptomyces hygroscopicus) in the production of ecofriendly alternative energy from waste. Afr J Biotechnol 2012;11:14320-5.

Brzezinski R, Dery CV, Beaulieu C. Thermostable xylanase DNA, protein and methods in use,” USA patent; 1999. p. 5871730.

Taibi Z, Saoudi B, Boudelaa M, Trigui H, Belghith H, Gargouri A, et al. Purification and biochemical characterization of a highly thermostable xylanase from Actinomadura sp. strain Cpt20 isolated from poultry compost. Appl Biochem Biotechnol 2012;166:663-79.

Aly MM, Tork S, Al-Garni SM, Nawar L. Streptomyces exfoliates LP10 isolated from oil contaminated soil. Afr J Microbiol Res 2012;6:1125-37.

Beyer M, Diekmann H. The chitinase system of Streptomyces sp. ATCC 11238 and its significance for fungal cell wall degradation. Appl Microbiol Biotechnol 1985;23:140-6.

Gooday GW. The ecology of chitin decomposition. Adv Microb Ecol 1990;11:387-430.

Taechowisan T, Peberdy JF, Lumyong S. Isolation of endophytic actinomycetes from selected plants and their antifungal activity. World J Microbiol Biotech 2003;19:381-5.

Usuki H Nitoda, Okuda T Kanzaki H. Screening and partial characterization of inhibitors of insect. Beta-N-acetylglucosaminidase. J Pesticide Sci 2006;31:41-6.

Jacob N, Poorna CA, Prema P. Purification and partial characterization of polygalacturonase from Streptomyces lydicus. Biores Technol 2008;99:66976701.

Janaki T. Keratinase activity (Feather) of streptomyces cacaoi subsp. cacaoi-M20. Int J Pharma Sci Res 2016;1:25-7.

Reading C, Cole M. Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrobial Agents Chemother 1977;11:852-7.

Goodfellow M, Williams ST. Ecology of actinomycetes. Ann Rev Microbiiol 1983;37:189-216.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 y from 1981 to 2010. J Nat Prod 2010;75:311-35.

Goodfellow M, Fiedler HP. A guide to successful bioprospecting: informed by actinobacterial systematics. Antonie Van Leeuwenhoek 2010;98:119-42.

Lazzarini A, Cavaletti L, Toppo G, Marinelli F. Rare genera of actinomycetes as potential producers of new antibiotics. Antonie Van Leeuwenhoek 2000;78:399-405.

Watve MG, Tickoo R, Jog MM, Bhole BD. How many antibiotics are produced by the genus Streptomyces? Arch Microbiol 2001;176:386-90.

Bérdy J. Are actinomycetes exhausted as a source of secondary metabolites? Biotechnologia 1995;7:13–34.

Wink JM, Kroppenstedt RM, Ganguli BN, Nadkarni SR, Schumann P, Seibert G, et al. Three new antibiotic producing species of the genus Amycolatopsis, Amycolatopsis balhimycina sp. nov., A. tolypomycina sp. nov., A. vancoresmycina sp. nov., and description of Amycolatopsis keratiniphila subsp. keratiniphila subsp. nov. and A. keratiniphila subsp. Mnogabecina subsp. nov. Syst Appl Microbiol 2003;26:38-46.

Tan G, Robinson S, Lacey E, Brown R, Kim W, Goodfellow M. Amycolatopsis regifaucium sp. nov., a novel actinomycete that produces kigamicins. Int J Syst Evol Microbiol 2007;57:2562-7.

Jensen P, Williams P, Zeigler L, Fenical W. Secondary metabolite production in marine actinomycetes of the Species-specific genus Salinispora. Appl Environ Microbiol 2007;73:1146-52.

Goodfellow M, Kumar Y, Labeda DP, Sembiring L. The Streptomyces violaceusniger clade: a home for streptomycetes with rugose ornamented spores. Antonie Van Leeuwenhoek 2007;92:173-99.

Jensen PR. Linking species concepts to natural product discovery in the post-genomic era. J Ind Microbiol Biotechnol 2010;37:219-24.

Ward AC, Goodfellow M. Phylogeny and functionality: taxonomy as a roadmap to genes. In: Microbial diversity and bioprospecting. A. T. Bull. Washington, D. C.: ASM Press; 2004. p. 288-313.

Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, et al. Complete genome sequence of the erythromycin-producing bacterium saccharopolyspora erythraea NRRL 23338. Nat Biotechnol 2007;25:447-53.

Weinstein MJ, Luedemann GM, Oden EM, Wagman GH, Rosselet JP, Marquez, et al. Gentamicin, a new antibiotic complex from Micromonospora. J Med Chem 1963;6:463-4.

Wagman GH, Weinstein MJ. Antibiotics from Micromonospora. Annu Rev Microbiol 1980;34:537-57.

Jin ZH, Lin JP, Xu ZN, Cen PL. Improvement of industry-applied rifamycin B-producing strain, Amycolatopsis mediterranei, by rational screening. J Gen Appl Microbiol 2002;48:329-34.

Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from actinoplanes teichomyceticus sp. nov. Antimicrob Agents Chemother 1984;26:917-23.

Jung HM, Jeya M, Kim SY, Moon HJ, Kumar Singh R, Zhang YW, et al., Biosynthesis, biotechnological production, application of teicoplanin: current state and perspectives. Appl Microbiol Biotechnol 2009;84:417-28.

Palanichamy V, Aachhari H, Mitra B, Reddy N. Optimization of cultivation parameters for growth and pigmen production by streptomyces spp. isolated from marine sediment and rhizosphere soil. IJPAES 2011;1:2231-4490.

Goodwin TW, Briton G. Distribution and analysis of carotenoids. Plant Pigments. Academic Press: London, United Kingdom; 1980.

Klein Marcuschamer D, Ajikumar PK, Stephanopoulos G. Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. Trends Biotechnol 2007;25:417-24.

Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005;26:459-516.

Young AJ, Lowe GM. Antioxidant and pro-oxidant properties of carotenoids. Arch Biochem Biophys 2001:385:20-7.

Nawani NN. Diversity of chitinases of bacterial origin. Ph. D. Thesis. University of Pune. Pune India; 2002.

Collins CH, Lyne PM, Granje JM. Microbiological methods. Butterworth and Heinemann publishers; 1995.

Kanavade VL. Use of bio-industrial waste for production of microbial biomass with potential in environmental management. Ph. D. Thesis, University of Pune, India; 2003.

Williams ST, Wellington EMH. Actinomycetes Ch. In: Methods of soil analysis. part 2. chemical and microbiological properties. America Inc Pub Madison Wisconsin USA 1982;45:969-87.

Shejul MS. Studies on heterotrophic filamentous procaryotes from aquatic habitats. Ph. D. Thesis, University of Pune India; 1998.

Zhang W, Li Z, Miao X, Zhang F. The screening of antimicrobial bacteria with diverse novel nonribosomal peptide synthetase (NRPS) genes from South China sea sponges. Mar Biotechnol (NY) 2009;11:346-55.

Selvameenal L, Radhakrishnan M, Balaraghunathan R. Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening. Indian J Pharm Sci 2009;71:499-504.

Lechevalier MP. Ecological associations involving actinomycetes. In: Actinomycetes Stuttgart: Gustav Fischer Verlag; 1981. p. 159-66.

Zaitlin B, Clayton G, Parkinson D, Turkington K. Streptomyces halstedii and overall actinomycete communities in agricultural soil. Appl Soil Ecol 2004;26:53-62.

Lee JY, Hwang BK. Diversity of antifungal actinomycetes in various vegetative soils of Korea. Can J Microniol Rev Can Microbiol 2002;48;407-17.

Strzelczyk E, Leniarska V. Production of B group vitamins by mycorrhizal fungiand actinomycetes isolated from the root zone of pine (Pinus silvestris L.). Plant Soil 1985;86:387-94.

Black MC, Beute MK. Soil components that affect severity of Cylindrocladium black rot on peanuts. Plant Disease 1985;69:36-9.

Goodfellow M, Williams ST, Mordarski M. Actinomycetes in biotechnology. Academic Press, London; 1988. p. 461-82.

Lemmel SA, Heimsch RC, Edwards LL. Optimizing the continuous production of Candida utilis and Saccharomycopsis fibuligera on potato processing waste water. Appl Env Microbiol 1979;37:227-33.

Fairbairn DA, Priest FG, Stark JRS. Extracellular amylase synthesis by Streptomyces limosus. Enz Microbi Technol 1986;8:89-92.

Shete HG. Cyanide degradation by streptomyces phacoviridae and Micromonospora braunna isolated from garden soil. M. Phil dissertation, University of Pune, India; 1995.

Goodfellow M, Cross T. Classification. In: The biology of actinomycetes. Academic Press, London; 1984. p. 7-164.

MacKenzie CR, Bilous D, Johnson KG. Sterptomyces flavogriseus cellulose: evaluation under various hydrolysis conditions. Biotechnol Bioengin 1984;26:590-4.



How to Cite

BAWAZIR, A. M. A. ., PALAKSHA, and M. . SHANTARAM. “AN IMPLICATION OF ACTINOMYCETES ON HUMAN WELL-BEING: A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 11, no. 5, May 2019, pp. 11-18, doi:10.22159/ijpps.2019v11i5.31829.



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