BENEFICIAL EFFECTS OF COFFEE AND MAINTENANCE OF URIC ACID LEVELS

Authors

  • Geetha Bhaktha Multidisciplinary Research Unit, Shimoga Institute of Medical Sciences, Shivamogga, Karnataka. India
  • Manjula Shantaram
  • Shivananda Nayak

Abstract

Objective: This study aimed in finding out if drinking coffee over a long term showed a marked influence on the serum uric acid level and Fasting blood glucose level.

Methods: The study population had 200 healthy subjects out of whom 143 were coffee drinkers and 90 diabetic subjects out of which 48 were coffee drinkers.

Results: It was seen that the mean value of uric acid in coffee consumers was significantly lower in both normal and diabetic study population. Further, the relation of Fasting blood glucose (FBG) with uric acid in diabetic coffee consuming study population was much linear than in the normal study population.

Conclusion: Since hyperglycemia and hyperuricemia are associated with the risk of cardiovascular disease and end-stage renal disorder in type 2 diabetes, coffee is considered to be useful in such subjects. The amounts of chlorogenic acid and caffeine in coffee are now considered beneficial on long term usage since it improves insulin sensitivity and lowers the uric acid and sugar level.

Keywords: Coffee, Fasting Blood Glucose, Type 2 diabetes, Uric acid.

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References

Van Dam RM, Feskens EJ. Coffee consumption and risk of type 2 diabetes mellitus. Lancet 2002;360:1477–8.

Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson S. Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study. J Intern Med 2004;255:89–95.

Ascherio A, Chen H. Caffeinated clues from the epidemiology of Parkinson’s disease. Neurology 2003;61: S51–4.

La Vecchia C. Coffee, liver enzymes, cirrhosis and liver cancer. J Hepatol 2005;42:444–6.

Welsch CA, Lachance PA, Wasserman BP. Dietary phenolic compounds: Inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. J Nutr 1989;119:1698–1704.

Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, et al. Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol 2007;2:16-21.

Gagliardi AC, Miname MH, Santos RD. Uric acid: a marker of increased cardiovascular risk. Atherosclerosis 2009;202:11-7.

Fox IH. Metabolic basis for disorders of nucleotide purine degradation. Metabolism 1981;30:616-34.

Ter Maaten JC, Voorburg A, Heine RJ, Ter Wee PM, Donker AJ, Gans RO. Renal handling of urate and sodium during acute physiological hyperinsulinemia in healthy subjects. Clin Sci (Lond) 1997;92:51–9.

Lamarine RJ. Selected health and behavioral effects are related to the use of caffeine. J Commun Health 1994;19:449−66.

Chou TM, Benowitz NL. Caffeine and coffee: effects on health and cardiovascular disease. Comp Biochem Physiol 1994;109:173−89.

Viani R. The composition of coffee. In: Garattini. editor. Caffeine, Coffee, and Health. New York, NY: Raven Press; 1993. p. 17–41.

Ohnaka K, Ikeda M, Maki T. Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. J Nutr Metab 2012. Doi.org/10.1155/2012/207426. [Article in Press]

Shilpa N Bhupathiraju, A Pan, Jo Ann E Manson, Walter C Willett, Rob M van Dam, Frank B Hu. Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women. Diabetologia 2014;57:1346–54.

Huxley R, Lee CM, Barzi F. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med 2009;169:2053–63.

Xu JG, Hu QP, Liu Y. Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem 2012;60:11625-30.

Richelle M, Tavazzi I, Offord E. Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J Agric Food Chem 2001;49:3438–42.

Van Dam RM, Pasman WJ, Verhoef P. Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers. Diabetes Care 2004;27:2990–2.

Clifford MN. Chlorogenic acid and other cinnamates: nature, occurrence, dietary burden, absorption, and metabolism. J Sci Food Agric 2000;80:1033–43.

Arion WJ, Canfield WK, Ramos FC, Schindler PW, Burger HJ, Hemmerle H. Chlorogenic acid and hydroxy nitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997;339:315–22.

Quinones galvan A, Natah A, baldi S, frascerra S, Sanna G, Ciociaro D, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995;268: E1-E5.

Hyon K Choi, Gary Curhan. Coffee, Tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Arthritis Rheum 2007;57:816–21.

Kiyohara C, Kono S, Honjo S, Todoroki I, Sakurai Y, Nishiwaki M. Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males. Br J Nutr 1999;82:125–30.

Published

01-04-2016

How to Cite

Bhaktha, G., M. Shantaram, and S. Nayak. “BENEFICIAL EFFECTS OF COFFEE AND MAINTENANCE OF URIC ACID LEVELS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 4, Apr. 2016, pp. 393-5, https://innovareacademics.in/journals/index.php/ijpps/article/view/7343.

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Section

Short Communication(s)