POTENTIAL IMPACT OF COQ10 AND VITAMIN E AGAINST (STZ) INDUCED METABOLIC DETERIORATION IN THE ALBINO RATS

  • Hanaa H. Ahmed Hormones Department
  • Hanan F. Aly National Research Centre, 33 El-Bohouth St
  • Sanaa A. Ali Therapeutic Chemistry Department, National Research Centre, 33 El-Bohouth St., Dokki 12622, Giza, Egypt

Abstract

Objective: This study evaluates the hypoglycemic effect of COQ10 and Vitamin E are determined using STZ induced diabetic rats.

Methods: Rats selected for this study were divided into five groups of ten rats each as follows: first group Normal control rats, the second is considered as diabetic groups, injected intraperitoneal with a single dose of STZ (60 mg/kg B. wt). the third group Diabetic rats orally administered glibenclamide drug 10 mg/kg B. wt daily for 30 d 4th. And 5th groups were treated orally glibenclamide combined with vitamin E (2% concentration added to the normal basal diet), or coenzyme Q10 at the dose of 10 mg/kg i. p. daily for 30 consecutive days in addition histological examinations of liver, kidney and brain were carried out to confirm the biochemical changes of the diabetic group of rats.

Results: All liver enzymes activities alanine and aspartate transferases and alkaline phosphatase (AST, ALT and ALP respectively), kidney function tests; creatinine and total urea, inflammatory biomarkers; CRP, IL-10 and TNF-α. Neurotransmitters; acetylcholine and acetylcholine esterase were enhanced with the highest degree in groups treated with COQ10 or vitamin E in addition to glibenclamide dug, almost restore the normal histological architecture of liver, kidney and brain.

Conclusion: Orally supplemented glibenclamide with coenzyme Q10 or vitamin E showing significantly reduced blood glucose levels in STZ induced diabetic rats. It also showed hypolipidemia as well as hepatoprotective effects, enhance histological feature of liver, kidney and brain.

 

Keywords: Hyperglycemia, coenzyme Q10, vitamin E, STZ, liver, kidney, brain

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Ahmed, H. H., H. F. Aly, and S. A. Ali. “POTENTIAL IMPACT OF COQ10 AND VITAMIN E AGAINST (STZ) INDUCED METABOLIC DETERIORATION IN THE ALBINO RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Sept. 2015, pp. 176-84, https://innovareacademics.in/journals/index.php/ijpps/article/view/7329.
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