PHENYLPROPANOIDS, EUGENOL SCAFFOLD, AND ITS DERIVATIVES AS ANTICANCER


Fadilah Fadilah, Arry Yanuar, Ade Arsianti, Retnosari Andrajati

Abstract


ABSTRACT
Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a
colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly
or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with
minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere
with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer
treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the
cancer cells and animal models.
Keywords: Eugenol, Derivatives of eugenol, Scaffold, Anticancer, Phenylpropanoids.


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About this article

Title

PHENYLPROPANOIDS, EUGENOL SCAFFOLD, AND ITS DERIVATIVES AS ANTICANCER

DOI

10.22159/ajpcr.2017.v10i3.16071

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 41-46

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

208 Views | 177 Downloads

Authors & Affiliations

Fadilah Fadilah
University of Indonesia
Indonesia

Arry Yanuar

Ade Arsianti

Retnosari Andrajati


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