THE RISKS OF USING TRANEXAMIC ACID AND VITAMIN K FOR DECREASING PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME VALUES IN INTRACRANIAL HEMORRHAGIC PATIENTS AT RUMAH SAKIT UMUM PUSAT FATMAWATI JAKARTA


Siti Zamilatul Azkiyah, Sudibyo Supardi, Retnosari Andrajati

Abstract


Objective: Intracranial hemorrhaging is a life-threatening condition that requires intensive treatment. Such hemorrhaging can happen spontaneously and may be caused by vascular malformations, trauma, or the administration of anticoagulant medications. The purpose of this study was to evaluate the risks of using tranexamic acid and Vitamin K for decreasing prothrombin time (PT) and activated partial thromboplastin time (aPTT) values in intracranial hemorrhagic patients.

Methods: This study used a retrospective cohort design, and data were taken from patients’ medical records at the medical record installation of Rumah Sakit Umum Pusat Fatmawati in Jakarta. A total of 125 medical records were selected based on the inclusion criteria. The first group included patients receiving only tranexamic acid, and the second group consisted of patients receiving both tranexamic acid and Vitamin K.

Results: Statistical analysis using Chi-squared testing for the first group showed a significant decrease in aPTT values, with p=0.000 (p<0.05), but there was no significant decrease in PT values, with p=0.314 (p<0.05). Statistical analysis using Chi-squared testing in the second group showed a significant decrease in aPTT values, with p=0.000 (p<0.05), and a significant decrease in PT values, with p=0.034 (p<0.05). Patients that used tranexamic acid and Vitamin K decreased the PT and aPTT values 2.7 times and 1, 6 times greater than patients without tranexamic acid and Vitamin K. Patients that used tranexamic acid decreased the PT and aPTT values 2.5 times and 1.2 times greater than patients without tranexamic acid.

Conclusions: The combination of tranexamic acid and Vitamin K is potentially more effective in decreasing of hemorrhaging.


Keywords


Tranexamic acid, Vitamin K, Anticoagulant, Prothrombin time, Activated partial thromboplastin time.

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About this article

Title

THE RISKS OF USING TRANEXAMIC ACID AND VITAMIN K FOR DECREASING PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME VALUES IN INTRACRANIAL HEMORRHAGIC PATIENTS AT RUMAH SAKIT UMUM PUSAT FATMAWATI JAKARTA

Keywords

Tranexamic acid, Vitamin K, Anticoagulant, Prothrombin time, Activated partial thromboplastin time.

DOI

10.22159/ajpcr.2017.v10s5.23117

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Special Issue October 2017 [PTMDS 2017] Page: 139-141

Print ISSN

0974-2441

Online ISSN

2455-3891

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Authors & Affiliations

Siti Zamilatul Azkiyah
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia.
Indonesia

Sudibyo Supardi
National Institute of Health Research Development, Ministry of Health, Republic of Indonesia, Jakarta, Indonesia.
Indonesia

Retnosari Andrajati
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Jakarta, Indonesia.
Indonesia


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