COMPARISON OF ZIDOVUDINE COMBINATION AND TENOFOVIR COMBINATION ON THE EFFECTIVENESS OF THERAPY AND SIDE EFFECTS IN HIV/AIDS PATIENTS IN RSAL MINTOHARDJO


PHIHANIAR INSANIPUTRI

Abstract


Objectives: Tenofovir-based therapy is a newly adopted first-line HIV/AIDS therapy regimen in Indonesia that is replacing the stavudine-based
regimen. However, zidovudine-based regimens remain the first-line therapy for patients with HIV/AIDS. This study aimed to compare the effectiveness
and incidence of adverse effects with hemoglobin (Hb) in both zidovudine- and tenofovir-based regimens in HIV/AIDS patients at Mintohardjo
Hospital.
Methods: We used a cross-sectional comparative research design. The data analyzed were medical records of all HIV/AIDS patients treated through
2015.
Results: The sample included 75 patients in the zidovudine group and 53 patients in the tenofovir group. Wilcoxon signed-rank tests indicated that
both combinations of therapy were effective in improving CD4+ cells. Initial CD4+ cell counts ≤ 200 cells/mm
were 4.55 times better at increasing
CD4+ cell counts when compared with an initial CD4+ > 200 cells/mm
3
3
. Chi-square results showed that both treatment combinations affected the
decrease in Hb. Patients using the zidovudine combination had 4.59 times greater risk for a Hb decrease compared with the tenofovir combination.
Conclusions: Zidovudine- and tenofovir-based regimens had similar effectiveness in increasing CD4+ cell counts, but the tendency to cause anemia
in tenofovir-based regimens was less than that of the zidovudine-based regimens.


| PDF |


About this article

Title

COMPARISON OF ZIDOVUDINE COMBINATION AND TENOFOVIR COMBINATION ON THE EFFECTIVENESS OF THERAPY AND SIDE EFFECTS IN HIV/AIDS PATIENTS IN RSAL MINTOHARDJO

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Special Issue October 2017 [PTMDS 2017] Page: 93-96

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

0 Views | 0 Downloads

Authors & Affiliations

PHIHANIAR INSANIPUTRI
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


Article Tools


Email this article (Login required)
Email the author (Login required)

Refbacks

  • There are currently no refbacks.