COMPARISON OF ADVERSE DRUG REACTIONS OF SECOND- AND THIRD-GENERATION ORAL CONTRACEPTIVES


KARTIKA CITRA DPS

Abstract


Objective: Oral contraceptives are the second-most widely used contraceptives in Indonesia; however, a high percentage rate of withdrawal is seen
owing to adverse drug reactions (ADRs). Only a small proportion of users have been provided information about other oral contraceptives such as
newer generation progestin as an alternative option to minimize ADR. This study aimed to compare the prevalence of ADR between combined oral
contraceptives containing levonorgestrel (LNG) (second generation) and desogestrel (DSG) (third generation), which was expected to have less side
effects.
Methods: The study has a cross-sectional comparative design with random sampling from users in six villages in Depok City, Indonesia. Data were
collected through interviews. The sample includes 60 users of LNG and 40 users of DSG.
Results: ADR complaints include intermenstrual bleeding (16.7% vs. 5%), headache (16.7% vs. 5%), nausea/vomiting (25% vs. 0%), breast tenderness
(13.3% vs. 0%), impaired sexual intercourse (23.3% vs. 7.5%), weight gain (35% vs. 22.5%), acne (3.3% vs. 7.5%), and face spots/chloasma (28.3%
vs. 5%). The LNG group showed significantly higher impaired sexual intercourse (odds ratio (OR): 3.75, 95% confidence interval (CI): 1.003-14.050,
p=0.039) and chloasma (OR 7.51, 95% CI: 1.629-34.647, p=0.004).
Conclusion: Users’ low knowledge of ADR and how to treat it could be a reason for drug withdrawal. Pharmacies must make efforts to provide
counseling in this regard.


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About this article

Title

COMPARISON OF ADVERSE DRUG REACTIONS OF SECOND- AND THIRD-GENERATION ORAL CONTRACEPTIVES

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Special Issue October 2017 [PTMDS 2017] Page: 134-138

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

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Authors & Affiliations

KARTIKA CITRA DPS
Department of Pharmacy, Faculty of Pharmacy, University Indonesia, Jakarta, Indonesia.
Indonesia


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