THE EFFECT OF TWEEN 80, PALM KERNEL OIL, AND ITS CONVERSION PRODUCT ON IN VITRO PENETRATION ENHANCEMENT OF INDOMETHACIN THROUGH RABBIT SKIN


Anayanti Arianto, Rizki Amelia, Hakim Bangun

Abstract


Objective: Objective of the study was to evaluate the effect of Tween 80, palm kernel oil (PKO), and its conversion products (hydrolyzed and transesterificated products) on the in vitro rabbit skin penetration of indomethacin from hydrocarbon ointment base.

Materials and Methods: In vitro penetration of indomethacin through hairless rabbit skin from hydrocarbon ointment base (white petrolatum) was evaluated using a diffusion cell. The effects of Tween 80, PKO, and its conversion products at various concentrations were evaluated.

Results: The higher of the concentration of Tween 80 until 5%, the higher of the indomethacin penetration. However, at the concentration above 5%, the penetration was decreased with the increasing concentration of Tween 80 used. The amount of indomethacin penetrated increased with the increasing of the concentration of PKO and its conversion products used. Hydrolyzed product showed the higher indomethacin penetration enhancing effect than PKO. Transesterificated product showed the highest penetration enhancing effect. However, the combination of Tween 80 with transesterificated product showed lower penetration enhancing effect compared to transesterificated product only.

Conclusion: Tween 80 at low concentrations, PKO, and its conversion products could be used to enhance indomethacin penetration.


Keywords


Indomethacin, Penetration, Tween 80, Palm kernel oil, Palm kernel oil conversion products.

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About this article

Title

THE EFFECT OF TWEEN 80, PALM KERNEL OIL, AND ITS CONVERSION PRODUCT ON IN VITRO PENETRATION ENHANCEMENT OF INDOMETHACIN THROUGH RABBIT SKIN

Keywords

Indomethacin, Penetration, Tween 80, Palm kernel oil, Palm kernel oil conversion products.

DOI

10.22159/ajpcr.2017.v10i7.18608

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 7 July 2017 Page: 284-288

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

53 Views | 75 Downloads

Authors & Affiliations

Anayanti Arianto
Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Center, University of Sumatera Utara, Jalan Tri Dharma No. 5, Kampus USU, Medan, Indonesia.
Indonesia

Rizki Amelia
Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Center, University of Sumatera Utara, Jalan Tri Dharma No. 5, Kampus USU, Medan, Indonesia.
Indonesia

Hakim Bangun
Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Center, University of Sumatera Utara, Jalan Tri Dharma No. 5, Kampus USU, Medan, Indonesia.
Indonesia


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